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Publikováno v:
Biological and Pharmaceutical Bulletin. 44:789-797
Sleep curtailment negatively affects cardiac activities and thus should be ameliorated by pharmacological methods. One of the therapeutic targets is melatonin receptors, which tune circadian rhythms. Ramelteon, a melatonin MT1/MT2 receptor agonist, h
Autor:
Masahiro Ishikane, Yoshiki Kusama, Ai Ebisui, Ayako Kawabe, Ryuji Koizumi, Ryo Inose, Norio Ohmagari, Saki Ishii, Yuichi Muraki, Ryota Goto, Tetsuya Yagi
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:816-821
Pseudomonas aeruginosa resistance is a major issue worldwide. Drug resistance is related to inappropriate antibiotic use. Because antipseudomonal agents have a wide spectrum, they must be used appropriately. The purpose of this study was to clarify t
Autor:
Napason Chabang, Somsak Fongsupa, Sirima Soodvilai, Sunhapas Soodvilai, Penjai Thongnuanjan, Pornpun Vivithanaporn, Patoomratana Tuchinda
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:830-837
Background Cisplatin is an effective chemotherapy but its main side effect, acute kidney injury, limits its use. Panduratin A, a bioactive compound extracted from Boesenbergia rotunda, shows several biological activities such as anti-oxidative effect
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:798-803
Our previous study showed that chronic skin colonization by Staphylococcus aureus exacerbated atopic dermatitis (AD) and that control of such skin colonization using antibiotic ointment might relieve AD-related skin inflammation. However, the role of
Autor:
Hong Wu, Minoru Yoshiyama, Yoshikatsu Okada, Yasukatsu Izumi, Takehiro Yamaguchi, Yoshio Ijiri, Hideki Imano, Atsuo Nomura, Yudai Yamaguchi, Takashi Nakano, Ryuji Kato, Tetsuya Hayashi, Maki Tamura, Michio Asahi
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:669-677
Pulmonary arterial hypertension (PAH) is a progressive condition that frequently results in right ventricular (RV) remodeling. The objectives of this study are to investigate effects of rivaroxaban on RV remodeling in a rat model of PAH, created with
Autor:
Norihisa Yasuda, Yoshifumi Ohchi, Koji Goto, Hiroki Itoh, Yosuke Suzuki, Ryota Tanaka, Takaaki Kitano, Daiki Eto, Ryosuke Tatsuta
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:737-741
For intensive care unit (ICU) patients, injectable voriconazole (VRCZ) is difficult to use because the patients often develop acute kidney injury. Since many ICU patients have consciousness disturbance, oral ingestion of tablet formulation is also di
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:707-713
High salt intake has been shown to induce hypertrophy and fibrosis in the atria and ventricles, which could result in the development of atrial fibrillation (AF). Whereas the development of AF is suggested to be prevented by renin-angiotensin system
Autor:
Tatsunori Suzuki, Tomoki Nishikawa, Masashi Nagata, Aya Enomoto, Yuuki Akagi, Takao Aoyama, Mai Hoshiko, Kenichi Negishi, Azusa Kujirai, Shuji Shimada, Saeko Nakamura, Emi Tsukada, Yasunari Mano, Satoshi Nakamatsu, Yohei Kawano
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:611-619
Oral anticoagulants (OACs) pose a major bleeding risk, which may be increased or decreased by concomitant medications. To explore medications that affect the bleeding risk of OACs, we conducted a nested case-control study including 554 bleeding cases
Autor:
Tatsuya Kitao, Megumi Yamamoto, Masaki Fukui, Yuma Ito, Shohei Furukawa, Hiroaki Shirahase, Ko Morishita
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:659-668
Peroxisome proliferator-activated receptor γ (PPARγ) modulators are expected to exert anti-diabetic effects without PPARγ-related adverse effects, such as fluid retention, weight gain, and bone loss. The present study showed that the novel tetrazo
Autor:
Mikio Hayashi, Tomoko Otsubaki, Yoshifumi Ueda, Sho Otake, Naofumi Uesato, Toshihiko Murayama
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:528-534
Psoriasis is an immune disorder-related inflammatory skin disease. Recent studies have suggested a contribution of T cell activation in the pathogenesis of psoriasis. Interleukin-2 (IL-2)-inducible T cell kinase (ITK) regulates T cell activation, inc