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Publikováno v:
Biological & Pharmaceutical Bulletin. 39:879-882
Intraocular irrigating solution containing 1 µg/mL adrenaline is widely used during cataract surgery to maintain pupil dilation. Prepared intraocular irrigating solutions are recommended for use within 6 h. After the irrigating solution is admistere
Autor:
Shinichiro Fuma, Tomoyo Imamura, Masamitsu Shimazawa, Kazuhiro Tsuruma, Yusuke Kanno, Hideaki Hara, Norihito Takano
Publikováno v:
Biological & Pharmaceutical Bulletin. 39:192-198
The combination of timolol and latanoprost, which are ocular hypotensive agents, has a greater ocular hypotensive effect than each as monotherapy. However, the protective effect of the combination is not well understood. In the present study, we inve
Autor:
Takehiko Yasuji, Keiichi Yoshihara, Kazuhiro Sako, Yuuki Kasashima, Noriyuki Namiki, Shinya Uchida
Publikováno v:
CHEMICAL & PHARMACEUTICAL BULLETIN. 64:1304-1309
The objective of this study was to establish the key factor of the lauryl sulfate (LS) salt/complex for sustained release of a hydrophilic drug at various physiological pH levels. Mirabegron is a hydrophilic drug that exhibits pH-dependent solubility
Autor:
Kazuko Nakagawa, Ryoko Kamihashi, Hiromi Soraoka, Ayaka Takashima, Kentaro Oniki, Norio Yasui-Furukori, Yoshihiro Uchiyashiki, Daisuke Kadowaki, Keishi Miyata, Tatsumasa Ono, Kazuki Matsuda, Kosuke Taharazako, Junji Saruwatari, Ayana Kita
Publikováno v:
Biological & Pharmaceutical Bulletin. 39:1468-1474
The concomitant use of herb and prescription medications is increasing globally. Herb-drug interactions are therefore a clinically important problem. Yokukansan (YKS), a Japanese traditional herbal medicine, is one of the most frequently used herbal
Autor:
Yan Chen, Yan Zhou, Bingxue Sun, Yanan Sun, Mengshu Wang, Shubo Liu, Yong Zhang, Wei Kong, Feng Li
Publikováno v:
Biological & Pharmaceutical Bulletin. 39:42-48
The purpose of this study was to investigate the gastrointestinal stability of exenatide to determine the key factor(s) contributing to peptide degradation during the oral delivery process. The effects of pH and various digestive enzymes on the degra
Publikováno v:
Biological & Pharmaceutical Bulletin. 39:1121-1129
Astroglial cells have been considered to have passive brain function by helping to maintain neurons. However, recent studies have revealed that the dysfunction of such passive functions may be associated with various neuropathological diseases, such
Publikováno v:
Biological & Pharmaceutical Bulletin. 39:1455-1460
To compare the effects of intrathecal dexmedetomidine and intrathecal morphine as supplements to bupivacaine in cesarean sections under spinal anesthesia. Full-term parturients (n=120) undergoing elective cesarean sections under spinal anesthesia wer
Autor:
Takahiro Yoshizawa, Kiyoshi Matsumoto, Shin Shimada, Takayuki Shindo, Takeshi Tokudome, Sho Takizawa
Publikováno v:
Biological & Pharmaceutical Bulletin. 39:737-746
Doxorubicin (DOX) is one of the best known anticancer drugs, and is used in the treatment of lymphoma, lung cancer, stomach cancer, and a number of other cancers. However, DOX has some serious side effects, the worst being lethal heart failure. Occas
Publikováno v:
CHEMICAL & PHARMACEUTICAL BULLETIN. 64:1607-1615
The primary objective of the present study was to develop extended-release matrix formulations of apremilast for the oral delivery and to study their in vitro and in vivo correlation. Five extended-release formulations containing hydroxypropylmethylc
Publikováno v:
Biological & Pharmaceutical Bulletin. 39:1623-1630
Neocarzinostatin (NCS) is a member of enediyne antibiotics with high anticancer potential. Our study was performed to explore the synergistic anti-glioma effects of NCS and paclitaxel (PTX) in vitro and in vivo. By 3-(4,5-dimethylthiazol-2-yl)-2,5-di