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Publikováno v:
Biological and Pharmaceutical Bulletin. 44:550-556
We previously reported a screening method for caloric restriction mimetics (CRM), a group of plant-derived compounds capable of inducing good health and longevity. In the present study, we explored the possibility of using this method to screen CRM d
Autor:
Fumiko Sekiguchi, Maho Tsubota, Atsufumi Kawabata, Saaya Fukushi, Kazuki Matsui, Kyoko Okazaki
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:461-464
T-Type Ca2+ channels (T-channels), particularly Cav3.2, are now considered as therapeutic targets for treatment of intractable pain including visceral pain. Among existing medicines, bepridil, a multi-channel blocker, used for treatment of arrhythmia
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:448-452
Antibiotic-associated diarrhea (AAD) is a typical side effect of antibiotic treatment, especially in children. Amoxicillin (AMPC) and amoxicillin/clavulanate (AMPC/CVA) are associated with high risk of AAD; however, these antibiotics are important in
Autor:
Masashi Nagata, Kenichi Negishi, Ayano Mori, Satoshi Nakamatsu, Namiki Sakamoto, Takao Aoyama, Yasunari Mano, Yohei Kawano, Maho Katsuyama, Shuji Shimada, Maki Obana
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:238-244
Mirtazapine (MTZ) is a noradrenergic and specific serotonergic antidepressant. MTZ is reportedly associated with an increased risk of bleeding. However, the underlying mechanism remains unclear. In this study, we investigated the antiplatelet effect
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:287-291
Dried terrestrial stems of Ephedra sinica are called 'Ephedra herb,' whose pharmacological effects are due mainly to two major ingredients, (-)-ephedrine and (+)-pseudoephedrine (total alkaloids which are defined in Japanese Pharmacopoeia (TA)). Ephe
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:225-231
The dermis is mainly constructed by type I collagen fibers, which provide mechanical strength to the skin by building a frame-like structure, and by elastic fibers, which provide elasticity to respond to movements of the skin. The depletion of collag
Autor:
Hiroko Nakamura, Takehiro Kawashiri, Daisuke Kobayashi, Takao Shimazoe, Nobuaki Egashira, Mayako Uchida
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:271-274
The anticancer agents including oxaliplatin, paclitaxel, and bortezomib cause severe peripheral neuropathy. The Kampo medicine Sokeikakketsuto (SOKT) has been widely used to treat several types of pain. In this study, the analgesic effects of SOKT on
Autor:
Iyuki Namekata, Shogo Hamaguchi, Hina Nisaka, Hikaru Tanaka, Shunsuke Hamazaki, Ryosuke Odaka
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:154-157
We developed a method to evaluate the activity of the Na+-Ca2+ exchanger (NCX) and sarco-endoplasmic reticulum Ca2+-ATPase (SERCA) with fluorescence microscopy in mouse ventricular cardiomyocytes. In non-beating ventricular cardiomyocytes, α-adrenoc
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:82-87
CYP epoxygenase-derived epoxyeicosatrienoic acids (EETs) contribute to endothelium-dependent hyperpolarization (EDH)-related dilation in multiple vascular beds. The present study aimed to determine the role of EETs in the acetylcholine (ACh)-induced
Autor:
Tokunori Ikeda, Erika Torigoe, Mariko Hamada, Yu Norikoshi, Fukuko Horio, Tomoe Tashiro, Makoto Anraku, Kodai Sasahara, Junji Saruwatari, Yuji Uchida, Mai Nagae
Publikováno v:
Biological and Pharmaceutical Bulletin. 43:1960-1965
The novel anti-influenza virus agent baloxavir marboxil is a selective inhibitor of an influenza cap-dependent endonuclease. Although a single oral dose in tablet form of baloxavir marboxil is expected to improve drug compliance and rapidly reduce vi