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Autor:
Masahiro Ishikane, Yoshiki Kusama, Ai Ebisui, Ayako Kawabe, Ryuji Koizumi, Ryo Inose, Norio Ohmagari, Saki Ishii, Yuichi Muraki, Ryota Goto, Tetsuya Yagi
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:816-821
Pseudomonas aeruginosa resistance is a major issue worldwide. Drug resistance is related to inappropriate antibiotic use. Because antipseudomonal agents have a wide spectrum, they must be used appropriately. The purpose of this study was to clarify t
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:707-713
High salt intake has been shown to induce hypertrophy and fibrosis in the atria and ventricles, which could result in the development of atrial fibrillation (AF). Whereas the development of AF is suggested to be prevented by renin-angiotensin system
Autor:
Tatsunori Suzuki, Tomoki Nishikawa, Masashi Nagata, Aya Enomoto, Yuuki Akagi, Takao Aoyama, Mai Hoshiko, Kenichi Negishi, Azusa Kujirai, Shuji Shimada, Saeko Nakamura, Emi Tsukada, Yasunari Mano, Satoshi Nakamatsu, Yohei Kawano
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:611-619
Oral anticoagulants (OACs) pose a major bleeding risk, which may be increased or decreased by concomitant medications. To explore medications that affect the bleeding risk of OACs, we conducted a nested case-control study including 554 bleeding cases
Autor:
Tatsuya Kitao, Megumi Yamamoto, Masaki Fukui, Yuma Ito, Shohei Furukawa, Hiroaki Shirahase, Ko Morishita
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:659-668
Peroxisome proliferator-activated receptor γ (PPARγ) modulators are expected to exert anti-diabetic effects without PPARγ-related adverse effects, such as fluid retention, weight gain, and bone loss. The present study showed that the novel tetrazo
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:448-452
Antibiotic-associated diarrhea (AAD) is a typical side effect of antibiotic treatment, especially in children. Amoxicillin (AMPC) and amoxicillin/clavulanate (AMPC/CVA) are associated with high risk of AAD; however, these antibiotics are important in
Autor:
Tokunori Ikeda, Erika Torigoe, Mariko Hamada, Yu Norikoshi, Fukuko Horio, Tomoe Tashiro, Makoto Anraku, Kodai Sasahara, Junji Saruwatari, Yuji Uchida, Mai Nagae
Publikováno v:
Biological and Pharmaceutical Bulletin. 43:1960-1965
The novel anti-influenza virus agent baloxavir marboxil is a selective inhibitor of an influenza cap-dependent endonuclease. Although a single oral dose in tablet form of baloxavir marboxil is expected to improve drug compliance and rapidly reduce vi
Autor:
Masahiro Ishikane, Yuichi Muraki, Ryota Goto, Tetsuya Yagi, Norio Ohmagari, Ai Ebisui, Ayako Kawabe, Ryo Inose, Yoshiki Kusama, Saki Ishii
Publikováno v:
Biological and Pharmaceutical Bulletin. 43:1906-1910
Patterns of the use of anti-methicillin-resistant Staphylococcus aureus (MRSA) agents in Japan might be influenced by the launch of new anti-MRSA agents, the publication of relevant guidelines, and the increase in the number of generic medicines. How
Autor:
Yoshihisa Kitamura, Satoru Esumi, Makoto Kajizono, Souichiro Ushio, Hikaru Sada, Toshiaki Sendo
Publikováno v:
Biological and Pharmaceutical Bulletin. 43:1699-1706
Lubiprostone is an effective drug for various types of constipation in patients without cancer; however, there is no report on its efficacy and safety in patients with cancer. Our purpose was to evaluate the efficacy and safety of lubiprostone for co
Publikováno v:
Biological and Pharmaceutical Bulletin. 43:1810-1813
An elevated plasma homocysteine level is an independent risk factor for cardiovascular diseases, neurological disorders, and pregnancy complications. We recently demonstrated partial lactation failure in cystathionine γ-lyase-deficient (Cth-/-) dam
Autor:
Kazutaka Matsushita, Shigeyuki Miyamura, Hirotaka Komaba, Koki Tokunaga, Shoma Tanaka, Takehiro Nakano, Masaki Otagiri, Toru Maruyama, Motoko Tanaka, Tadashi Imafuku, Hitoshi Maeda, Kenshiro Hirata, Masafumi Fukagawa, Daisuke Kadowaki, Hiroshi Watanabe, Hiromasa Kato
Publikováno v:
Biological and Pharmaceutical Bulletin. 43:1583-1590
Chronic kidney disease (CKD) patients with secondary hyperparathyroidism (SHPT) have an increased risk of cardiovascular disease (CVD). Cinacalcet is a calcimimetic that permits impaired endothelial functions to be recovered via inhibiting parathyroi