Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Stephen H. Bryant"'
Publikováno v:
Bioinformatics. 33:1621-1629
Motivation Genetic variants in drug targets and metabolizing enzymes often have important functional implications, including altering the efficacy and toxicity of drugs. Identifying single nucleotide variants (SNVs) that contribute to differences in
Autor:
Siqian He, Jian Zhang, Jiyao Wang, Tiejun Cheng, Benjamin A. Shoemaker, Asta Gindulyte, Yanli Wang, Tugba O. Suzek, Stephen H. Bryant
Publikováno v:
Nucleic Acids Research
PubChem's BioAssay database (http://pubchem.ncbi.nlm.nih.gov) is a public repository for archiving biological tests of small molecules generated through high-throughput screening experiments, medicinal chemistry studies, chemical biology research and
Autor:
Ratna R. Thangudu, Aron Marchler-Bauer, Jessica H. Fong, Dachuan Zhang, Anna R. Panchenko, Manoj Tyagi, Benjamin A. Shoemaker, Thomas Madej, Stephen H. Bryant
Publikováno v:
Nucleic Acids Research
We have recently developed the Inferred Biomolecular Interaction Server (IBIS) and database, which reports, predicts and integrates different types of interaction partners and locations of binding sites in proteins based on the analysis of homologous
Publikováno v:
Bioinformatics
Motivation: Most of the previous data mining studies based on the NCI-60 dataset, due to its intrinsic cell-based nature, can hardly provide insights into the molecular targets for screened compounds. On the other hand, the abundant information of th
Autor:
Evan E Bolton, Stephen H. Bryant, Karen Karapetyan, Jian Zhang, Yanli Wang, Tugba O. Suzek, Svetlana Dracheva, Benjamin A. Shoemaker, Jiyao Wang, Jewen Xiao
Publikováno v:
Nucleic Acids Research
The PubChem BioAssay database (http://pubchem.ncbi.nlm.nih.gov) is a public repository for biological activities of small molecules and small interfering RNAs (siRNAs) hosted by the US National Institutes of Health (NIH). It archives experimental des
Autor:
Eric W. Sayers, Tanya Barrett, Dennis A. Benson, Evan Bolton, Stephen H. Bryant, Kathi Canese, Vyacheslav Chetvernin, Deanna M. Church, Michael DiCuccio, Scott Federhen, Michael Feolo, Lewis Y. Geer, Wolfgang Helmberg, Yuri Kapustin, David Landsman, David J. Lipman, Zhiyong Lu, Thomas L. Madden, Tom Madej, Donna R. Maglott, Aron Marchler-Bauer, Vadim Miller, Ilene Mizrachi, James Ostell, Anna Panchenko, Kim D. Pruitt, Gregory D. Schuler, Edwin Sequeira, Stephen T. Sherry, Martin Shumway, Karl Sirotkin, Douglas Slotta, Alexandre Souvorov, Grigory Starchenko, Tatiana A. Tatusova, Lukas Wagner, Yanli Wang, W. John Wilbur, Eugene Yaschenko, Jian Ye
Publikováno v:
Nucleic Acids Research
Scopus-Elsevier
Scopus-Elsevier
In addition to maintaining the GenBank® nucleic acid sequence database, the National Center for Biotechnology Information (NCBI) provides analysis and retrieval resources for the data in GenBank and other biological data made available through the N
Autor:
Thomas Madej, Manoj Tyagi, Benjamin A. Shoemaker, Aron Marchler-Bauer, Dachuan Zhang, Stephen H. Bryant, Ratna R. Thangudu, Anna R. Panchenko, Jessica H. Fong
Publikováno v:
Nucleic Acids Research
IBIS is the NCBI Inferred Biomolecular Interaction Server. This server organizes, analyzes and predicts interaction partners and locations of binding sites in proteins. IBIS provides annotations for different types of binding partners (protein, chemi
Publikováno v:
Bioinformatics
This work provides an analysis of across-target bioactivity results in the screening data deposited in PubChem. Two alternative approaches for grouping-related targets are used to examine a compound's across-target bioactivity. This analysis identifi
Publikováno v:
Nucleic Acids Research
PubChem (http://pubchem.ncbi.nlm.nih.gov) is a public repository for biological properties of small molecules hosted by the US National Institutes of Health (NIH). PubChem BioAssay database currently contains biological test results for more than 700
Autor:
Farideh Chitsaz, Mikhail Mullokandov, Stephen H. Bryant, Siqian He, Jessica H. Fong, John B. Anderson, Fu-er Lu, Asba Tasneem, Myra K. Derbyshire, David I. Hurwitz, Renata C. Geer, Roxanne A. Yamashita, Carol DeWeese-Scott, James S. Song, Christopher J. Lanczycki, Zhaoxi Ke, Cynthia A. Liebert, Shennan Lu, Chunlei Liu, Dachuan Zhang, Noreen R. Gonzales, Naigong Zhang, Narmada Thanki, Lewis Y. Geer, John D. Jackson, Gabriele H. Marchler, Aron Marchler-Bauer, Marc Gwadz
Publikováno v:
Nucleic Acids Research
NCBI's Conserved Domain Database (CDD) is a collection of multiple sequence alignments and derived database search models, which represent protein domains conserved in molecular evolution. The collection can be accessed at http://www.ncbi.nlm.nih.gov