Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Philip Van Damme"'
Autor:
Sien Hilde Van Daele, Matthieu Moisse, Joke J F A van Vugt, Ramona A J Zwamborn, Rick van der Spek, Wouter van Rheenen, Kristel Van Eijk, Kevin Kenna, Philippe Corcia, Patrick Vourc'h, Philippe Couratier, Orla Hardiman, Russell McLaughin, Marc Gotkine, Vivian Drory, Nicola Ticozzi, Vincenzo Silani, Antonia Ratti, Mamede de Carvalho, Jesús S Mora Pardina, Monica Povedano, Peter M Andersen, Markus Weber, Nazli A Başak, Chris Shaw, Pamela J Shaw, Karen E Morrison, John E Landers, Jonathan D Glass, Michael van Es, Leonard H van den Berg, Ammar Al-Chalabi, Jan Veldink, Philip Van Damme
Publikováno v:
Brain.
With the advent of gene therapies for amyotrophic lateral sclerosis, there is a surge in gene testing for ALS. Although there is ample experience with gene testing for C9orf72, SOD1, FUS and TARDBP in familial ALS, large studies exploring genetic var
Autor:
Ahmad Al-Khleifat, Philip Van Damme, Richard Dobson, Leonard H. van den Berg, Wim Robberecht, Adriano Chiò, Vincenzo Silani, Peter M. Andersen, Aleksey Shatunov, Bradley N. Smith, Jan H. Veldink, Isabella Fogh, Orla Hardiman, Alfredo Iacoangeli, Simon Topp, Christopher Shaw, Sashika Selvackadunco, Antonia Ratti, Gerome Breen, Andrea Calvo, Sarah Opie-Martin, Claire Troakes, Ammar Al-Chalabi, Ashley R. Jones, Wouter van Rheenen
Publikováno v:
Brain Communications
Evidence indicates that common variants found in genome-wide association studies increase risk of disease through gene regulation via expression Quantitative Trait Loci. Using multiple genome-wide methods, we examined if Single Nucleotide Polymorphis
Publikováno v:
Clinical Chemistry. 61:1133-1135
A 62-year-old woman noticed muscle weakness in the right leg, which was followed a few months later by weakness in the left leg. Over a 6-month period, the muscle weakness progressed to the upper limbs. One year after onset, the patient was referred
Autor:
Ines Taes, Ludo Van Den Bosch, Mieke Timmers, Johan Auwerx, Philip Van Damme, Nicole Hersmus, Wim Robberecht, André Bento-Abreu
Publikováno v:
Human Molecular Genetics; Vol 22
Human Molecular Genetics
Human Molecular Genetics
Defects in axonal transport are thought to contribute to the pathogenesis of neurodegenerative disease. Because α-tubulin acetylation facilitates axonal transport, inhibition of the α-tubulin deacetylating enzymes, histone deacetylase 6 (Hdac6) and
Autor:
Benno Küsters, Sarah Herdewyn, Hui Zhao, Joke Reumers, Diether Lambrechts, Gert Matthijs, Valerie Race, Matthieu Moisse, Philip Van Damme, Leonard H. van den Berg, Wim Robberecht, Helenius J. Schelhaas, An Goris
Publikováno v:
Human Molecular Genetics; Vol 21
Human Molecular Genetics, 21, 11, pp. 2412-9
Human Molecular Genetics
Human Molecular Genetics, 21, 2412-9
Human Molecular Genetics, 21, 11, pp. 2412-9
Human Molecular Genetics
Human Molecular Genetics, 21, 2412-9
Item does not contain fulltext Motor neuron degeneration in amyotrophic lateral sclerosis (ALS) has a familial cause in 10% of patients. Despite significant advances in the genetics of the disease, many families remain unexplained. We performed whole
Publikováno v:
Journal of Neuropathology & Experimental Neurology. 64:605-612
AMPA receptor-mediated excitotoxicity has been implicated in the selective degeneration of motor neurons in amyotrophic lateral sclerosis (ALS). Motor neurons in vitro are particularly vulnerable to excessive AMPA receptor stimulation and one of the