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Publikováno v:
Journal of Pharmacy and Pharmacology. 70:1102-1112
ObjectivesInflammation plays an important role in the pathogenesis of diabetic nephropathy (DN). The aim of this study was to explore the anti-inflammatory role of PTY-2r (extracted from Pueraria tuberosa), on streptozotocin (STZ)-induced DN rats.Met
Autor:
Noriko Yamabe, Takako Yokozawa, Naotoshi Shibahara, Hirozo Goto, Yutaka Shimada, Dong Young Rhyn, Takako Nakagawa
Publikováno v:
Journal of Pharmacy and Pharmacology. 57:1205-1212
Diabetes mellitus is now the most common cause of end-stage renal failure. In this study, the effects of Hachimi-jio-gan on diabetic kidney damage in spontaneously diabetic WBN/Kob rats were examined. Oral administration of Hachimi-jio-gan to WBN/Kob
Publikováno v:
Alcohol and Alcoholism. 36:286-291
The alcohol-preferring AA (Alko Alcohol) rats are more rapidly sensitized to the locomotor activity-stimulating effects of small doses of morphine than the alcohol-avoiding ANA (Alko Non-Alcohol) rats. To study the involvement of dopaminergic and ser
Publikováno v:
International Journal of Neuropsychopharmacology
Ardalan, M, Wegener, G, H Rafati, A & R Nyengaard, J 2017, ' S-Ketamine Rapidly Reverses Synaptic and Vascular Deficits of Hippocampus in Genetic Animal Model of Depression ', International Journal of Neuropsychopharmacology, vol. 20, no. 3, pp. 247-256 . https://doi.org/10.1093/ijnp/pyw098
Ardalan, M, Wegener, G, H Rafati, A & R Nyengaard, J 2017, ' S-Ketamine Rapidly Reverses Synaptic and Vascular Deficits of Hippocampus in Genetic Animal Model of Depression ', International Journal of Neuropsychopharmacology, vol. 20, no. 3, pp. 247-256 . https://doi.org/10.1093/ijnp/pyw098
Background: The neurovascular plasticity of hippocampus is an important theory underlying major depression. Ketamine as a novel glutamatergic antidepressant drug can induce a rapid antidepressant effect within hours. In a mechanistic proof of this co
Publikováno v:
Journal of Pharmacy and Pharmacology. 46:833-837
Oral administration of indobufen to male rats for three days at daily doses of 5, 10 and 20 mg kg−1 resulted in no changes in liver total glutathione, cytosolic glutathione S-transferases or microsomal epoxide hydrolase. Reduced glutathione appeare
Autor:
Kanji Takada, Shozo Muranishi, Takayuki Douen, Masahiro Murakami, Minoru Hashizume, Akira Yamamoto
Publikováno v:
Journal of Pharmacy and Pharmacology. 44:555-559
The intestinal absorption of 125I-labelled palmitoyl insulin was examined following administration into in-situ closed large intestinal loops of rats. When mono- and dipalmitoyl insulins (Palins-1 and Palins-2, respectively) were administered in poly
Publikováno v:
Journal of Pharmacy and Pharmacology. 44:565-569
The effects of bile and site of gastrointestinal absorption on the lymphatic absorption of the highly lipophilic drug, mepitiostane were examined using thoracic duct-cannulated rats. The lymphatic absorption from the small intestine was very small in
Autor:
Jan Noordhoek, M. A. Freeke Hamelijnck, Andries S. Koster, Gerard A. Hofman, Michiel H. De Vries
Publikováno v:
Journal of Pharmacy and Pharmacology. 44:311-314
The contribution of the rat small intestine to systemic and presystemic elimination of l-dopa was studied. When l-dopa was administered into the vascular perfusate, a systemic extraction ratio of 0·38 was found, the major part being decarboxylated t
Publikováno v:
Journal of Pharmacy and Pharmacology. 44:306-310
Four kinin-releasing enzymes, trimucase I, II, III and IV, isolated from Trimeresurus mucrosquamatus venom (TMV) caused rat hind-paw swelling. Trimucase I and III were less potent than trimucase II and IV in this effect. Pretreatment with diphenhydra
Autor:
Sheila A Doggrell
Publikováno v:
Journal of Pharmacy and Pharmacology. 44:239-243
Differing effects of (±)-celiprolol at β-adrenoceptors have been reported. The effects of (±)-, (+)- and (—)-celiprolol on the contractile responses of the rat left atria and portal vein have therefore been studied. (±)-Celiprolol did not augme