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Autor:
Russell R. Kempker, Charles A. Peloquin, Henry M. Blumberg, Zaza Avaliani, Jeffrey M. Collins, Shorena Sabanadze, Maia Kipiani, Mariam Gujabidze, Tinatin Bakuradze, Alison Smith, Mohammad H. Al-Shaer, Teona Avaliani
Publikováno v:
Clin Infect Dis
Background The ability of antituberculosis drugs to cross the blood–brain barrier and reach the central nervous system is critical to their effectiveness in treating tuberculosis meningitis (TBM). We sought to fill a critical knowledge gap by provi
Autor:
R K Shandil, Nathella Pavankumar, Hemanth Kumar, Devaraju Reddy, Anant Mohan, Jaykumar Menon, L Sekar, Chandrasekaran Padmapriydarsini, Metrif Team, P. Ramesh, Megha Mamulwar, Randeep Guleria, N S Gomathy, Prema Shanmugam, Shaheed M Jawahar, Chandra Suresh, Poornaganga Devi, Abhijeet Kadam, Manjula Singh, Urvashi B. Singh, Aarti Mane
Publikováno v:
Clinical Infectious Diseases. 75:425-434
Background Metformin, by reducing intracellular Mycobacterium tuberculosis growth, can be considered an adjunctive therapy to anti-tuberculosis treatment (ATT). We determined whether metformin with standard ATT reduces time to sputum culture conversi
Autor:
Eldon Spackman, Elissa Rennert-May, Kwadwo Mponponsuo, Daniel B. Gregson, Ranjani Somayaji, Jenine Leal
Publikováno v:
Journal of Antimicrobial Chemotherapy. 77:507-516
Background Gram-negative pathogens, such as Escherichia coli, are common causes of bloodstream infections (BSIs) and increasingly demonstrate antimicrobial resistance. Molecular rapid diagnostic tests (mRDTs) offer faster pathogen identification and
Autor:
H.J.M. van Kan, Peter E. Spronk, E. J F Franssen, T H Geersing, P. H. J. van der Voort, M den Reijer
Publikováno v:
The Journal of antimicrobial chemotherapy, 77(1), 246-252. Oxford University Press
Background Continuous infusion of conventional amphotericin B (CCAB) is used in ICUs for pre-emptive treatment of invasive fungal infections. Amphotericin B has previously been associated with nephrotoxicity. Objectives To investigate if CCAB with th
Publikováno v:
Journal of Antimicrobial Chemotherapy
The long-acting antiretroviral cabotegravir and rilpivirine combination has just received FDA, EMA and Health Canada approval. This novel drug delivery approach is about to revolutionize the therapy of people living with HIV, decreasing the 365 daily
Publikováno v:
Journal of Antimicrobial Chemotherapy
Objectives To investigate the population pharmacokinetics of posaconazole gastroresistant tablets in children with cystic fibrosis (CF) and perform simulations to recommend optimal doses. Patients and methods Children from a paediatric CF centre who
Autor:
Hawazin A Shaikh, Mohammed E Mohammed Ali, Zied Gaifer, Basmah H AlJehani, Sheikheldin B Hussein
Publikováno v:
Transactions of The Royal Society of Tropical Medicine and Hygiene. 116:133-138
Background Brucellosis causes a disabling human disease and loss of animals' lives. The clinical significance of Brucella bacteremia is still unclear and Brucella identification in blood culture is suboptimal. Methods This was a retrospective study c
Publikováno v:
Journal of the Pediatric Infectious Diseases Society. 10:891-900
Background Pneumonia causes significant morbidity and mortality in children worldwide, especially in resource-poor settings. Accurate identification of bacterial etiology leads to timely antibiotic initiation, minimizing overuse, and development of r
Autor:
Ei Phyo Win, Ranjith Kumar Sivakumar, Samuel K. Ayeh, Marie Gilbert Majella, Vignesh Chidambaram, Enoch J. Abbey, Akshay Gupte, Siqing Wang, Amudha Kumar, Jann-Yuan Wang, Pranita Neupane, Nyan Lynn Tun, Petros C. Karakousis, Alyssa Zimmerman, Jennie Ruelas Castillo, Jaime Friel Blanck
Publikováno v:
Clin Infect Dis
Background Although the incidence of tuberculosis is higher in men than in women, the relationship of sex with tuberculosis treatment outcomes has not been adequately studied. Methods We performed a retrospective cohort study and a systematic review
Publikováno v:
J Antimicrob Chemother
In 2020, new vancomycin guidelines were released, recommending the transition from trough-based to AUC24 monitoring for adult and paediatric patients. Given the resources required to achieve this transition, there has been debate about the costs and