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Autor:
Russell R. Kempker, Charles A. Peloquin, Henry M. Blumberg, Zaza Avaliani, Jeffrey M. Collins, Shorena Sabanadze, Maia Kipiani, Mariam Gujabidze, Tinatin Bakuradze, Alison Smith, Mohammad H. Al-Shaer, Teona Avaliani
Publikováno v:
Clin Infect Dis
Background The ability of antituberculosis drugs to cross the blood–brain barrier and reach the central nervous system is critical to their effectiveness in treating tuberculosis meningitis (TBM). We sought to fill a critical knowledge gap by provi
Autor:
R K Shandil, Nathella Pavankumar, Hemanth Kumar, Devaraju Reddy, Anant Mohan, Jaykumar Menon, L Sekar, Chandrasekaran Padmapriydarsini, Metrif Team, P. Ramesh, Megha Mamulwar, Randeep Guleria, N S Gomathy, Prema Shanmugam, Shaheed M Jawahar, Chandra Suresh, Poornaganga Devi, Abhijeet Kadam, Manjula Singh, Urvashi B. Singh, Aarti Mane
Publikováno v:
Clinical Infectious Diseases. 75:425-434
Background Metformin, by reducing intracellular Mycobacterium tuberculosis growth, can be considered an adjunctive therapy to anti-tuberculosis treatment (ATT). We determined whether metformin with standard ATT reduces time to sputum culture conversi
Autor:
Amy Lin, Paola Cinque, Carmela Pinnetti, Valeria De Zan, Alan Winston, Andrea Calcagno, Gustaf Ulfhammer, Bruce J Brew, Arvid Edén, Staffan Nilsson, Cristiana Oprea, Mattia Trunfio, Lars Hagberg, Andrea Antinori, Richard W. Price, Magnus Gisslén, Serena Spudich
Publikováno v:
Clinical Infectious Diseases. 75:493-502
Background The aim of this large multicenter study was to determine variations in cerebrospinal fluid (CSF) HIV-RNA in different phases of untreated human immunodeficiency virus type 1 (HIV-1) infection and its associations with plasma HIV-RNA and ot
Autor:
Hao-Chien Wang, Chong-Jen Yu, Jann-Yuan Wang, Wei-Juin Su, Chin-Chung Shu, Sheng-Wei Pan, Mei-Lin Ho, Yu-Jiun Chan, Yuh Min Chen, Jia-Yih Feng
Publikováno v:
Clinical Infectious Diseases. 75:239-247
Background In patients with nodular bronchiectatic (NB) nontuberculous mycobacterial lung disease (NTM-LD), risk factors for disease progression have not been clearly investigated. The roles of cavitary NB and soluble programmed death protein-1 (sPD-
Autor:
Jacques Gasnault, Pierre-Hadrien Becker, Lionelle Nkam, Antoine Cheret, Anne-Marie Taburet, Aurélie Barrail-Tran, Valérie Furlan, Pilartxo Catalan, Cécile Goujard, Thibaut Gelé, Hélène Gouget, Coralie Pallier, Alicia Castro Gordon
Publikováno v:
Journal of Antimicrobial Chemotherapy
Journal of Antimicrobial Chemotherapy, 2021, 76 (12), pp.3280-3285. ⟨10.1093/jac/dkab334⟩
Journal of Antimicrobial Chemotherapy, 2021, 76 (12), pp.3280-3285. ⟨10.1093/jac/dkab334⟩
Objectives The penetration of antiretroviral drugs into deep compartments, such as the CNS, is a crucial component of strategies towards an HIV cure. This study aimed to determine CSF concentrations of bictegravir, emtricitabine and tenofovir in pati
Autor:
Liang Chen, Yanzhong Peng, Chunmei Liu, Guangming Li, Hesong Cui, Zong Zhang, Weidong Liu, Z.S. Jin, Xinwen Song, Qing Mao, Qianguo Mao, Yanhang Gao, Jia Shang, Junqi Niu, Xueyuan Jin, Peng Wang, Dengke Zhang, Fei Kong, Jidong Jia, Xiaolu Wu, Daidi Wang, Xiuhong Wen, Caiyan Zhao, Huanyu Gong, Wen Chen, Yanhua Ding, Lvfeng Yao, Xuebing Yan, Qingjing Zhu, Yongfeng Yang, Jinyu Xia, Mao Mu, Weili Jin, Tao Han
Publikováno v:
Clinical Infectious Diseases. 74:1925-1932
Background Pradefovir is a liver-targeted prodrug of adefovir, a nucleoside/nucleotide analogue with antiviral activity against hepatitis B virus (HBV) DNA polymerase. This phase 2 study compared the efficacy and safety of oral pradefovir (30, 45, 60
Publikováno v:
Journal of Antimicrobial Chemotherapy
Objectives To investigate the population pharmacokinetics of posaconazole gastroresistant tablets in children with cystic fibrosis (CF) and perform simulations to recommend optimal doses. Patients and methods Children from a paediatric CF centre who
Autor:
Walter Plöchl, Arthur Hosmann, Stefan Poschner, Karl Rössler, Lavinia Ritscher, Heinz Burgmann, Maria Sanz Codina, Beatrix Wulkersdorfer, Valentin Al Jalali, Markus Zeitlinger, Andreas Gruber, Michael Wölfl-Duchek, Walter Jäger, Andrea Reinprecht
Publikováno v:
Journal of Antimicrobial Chemotherapy. 76:2914-2922
Background Inadequate antibiotic exposure in cerebral infections might have detrimental effects on clinical outcome. Commonly, antibiotic concentrations within the CSF were used to estimate cerebral target levels. However, the actual pharmacological
Publikováno v:
Journal of Antimicrobial Chemotherapy
Objectives To evaluate the effects of concomitant efavirenz-based ART and genetic polymorphism on the variability in rifampicin and 25-desacetylrifampicin pharmacokinetics. Patients and methods Plasma concentrations of rifampicin and 25-desacetylrifa
Autor:
Su Ann Ho, Robin K. Avery, Carolina Garcia-Vidal, David J Epstein, Monica A. Slavin, Oliver A. Cornely, Christof Scheid, Celia Cardozo, Anat Stern, Yasmine Abi Aad, Johan Maertens, Seema Mehta Steinke, Michelle K Yong, Genovefa A. Papanicolaou, Carolyn D. Alonso, Dionysios Neofytos, Philipp Koehler
Publikováno v:
J Antimicrob Chemother
Objectives To evaluate the safety and efficacy of cidofovir for the treatment of double-stranded DNA (dsDNA) viral infections following allogeneic haematopoietic cell transplant (HCT). Methods This was a retrospective multicentre cohort study includi