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Publikováno v:
Journal of Pharmacy and Pharmacology. 44:565-569
The effects of bile and site of gastrointestinal absorption on the lymphatic absorption of the highly lipophilic drug, mepitiostane were examined using thoracic duct-cannulated rats. The lymphatic absorption from the small intestine was very small in
Publikováno v:
Journal of Pharmacy and Pharmacology. 43:529-534
The actions of hydroalcoholic and tea extracts of stems of Leonotis nepetaefolia on agonist-induced and electrically-evoked contractions have been analysed in-vitro in rat uterus and left atrium and in guinea-pig ileum and trachea. The tea extract (5
Publikováno v:
Journal of Pharmacy and Pharmacology. 43:421-424
The hypothermic action of the thiazoloazepine derivative B-HT 920, an α2-adrenoceptor agonist has been investigated in rats. B-HT 920 (6-allyl-2-amino-5,6,7,8-tetrahydro-4H-thiazolo-(4,5-d)-azepine dihydrochloride) (0·25–10 mg kg−1 i.p.) induce
Autor:
Lisa G. White, Robert P. Shrewsbury
Publikováno v:
Journal of Pharmacy and Pharmacology. 42:813-816
Antipyrine disposition has been determined in the rat following administration of Fluosol-DA by an intravenous infusion without blood removal or a haemodilution procedure, and compared with data from sham haemodiluted rats (blood removed and returned
Publikováno v:
Journal of Pharmacy and Pharmacology. 42:698-703
Administration of dapsone (33 mg kg−1) to intact rats resulted in a marked elevation of methaemoglobin levels in male (435.0 ± 105.2% met Hb h) compared with female rats (59.0 ± 17.2% met Hb h). However, the clearance of dapsone was significantly
Publikováno v:
Journal of Pharmacy and Pharmacology. 42:242-246
γ-L-Glutamyl-L-dopa (gludopa) is believed to be a dopamine prodrug specific for the kidney. Its pharmacokinetics have been studied in the rat given 50 mg kg−1 intravenously (i.v.) and 60 mg kg−1 intraperitoneally (i.p.). By the i.v. route, elimi
Publikováno v:
Journal of Pharmacy and Pharmacology. 42:186-190
Direct evidence has been sought as to what extent the sensitization of heart to the arrhythmogenic action of sympathomimetic drugs in the presence of the inhalatory anaesthetics, halothane, isoflurane and enflurane, is mediated by either α- or β- a
Publikováno v:
Journal of Pharmacy and Pharmacology. 42:108-114
Inflammation of the rat bile duct induced by administration of turpentine into it has been used to study the influence of the impaired duct on liver function. Turpentine was dissolved in olive oil 1:1000 and 1:500. A 2 h ligation of the bile duct was
Publikováno v:
Journal of Pharmacy and Pharmacology. 43:741-743
The influence of the dihydropyridine calcium antagonist nifedipine has been studied on the diuretic response to frusemide, acetazolamide and hydrochlorothiazide in water-loaded (25 mL kg−1) conscious rats. Oral administration of nifedipine (10 mg k
Publikováno v:
Journal of Pharmacy and Pharmacology. 43:207-209
Human cartilage biopsies incubated for 2 days in-vitro with 15% synovial fluid from rheumatoid arthritis patients contained less glycosaminoglycans (GAG) than control biopsies. Recombinant human (rHu-) interleukin-1α (IL-1α) and IL-1β at 10 or 100