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Autor:
Kenji Tsukigawa, Keishi Yamasaki, Hakaru Seo, Masaki Otagiri, Koji Nishi, Kazuaki Taguchi, Keiki Sakurama
Publikováno v:
Journal of Pharmacy and Pharmacology. 74:88-93
Objectives Echinocandins are widely used for the treatment of invasive fungal diseases. While they bind strongly to plasma proteins, our knowledge of this process is not sufficient to permit their pharmacokinetics and pharmacodynamics targets to be d
Publikováno v:
Rheumatology. 61:3071-3081
Objective To identify the role of fatty acid binding protein 3 (FABP3) in vascular fibrosis in Takayasu’s arteritis (TAK) and to explore the underlying molecular mechanism. Methods The expression of FABP3 and extracellular matrix proteins (ECMs) we
Autor:
Kazuhiro Iguchi, Hiroaki Takasawa, Yukino Nagao, Toshiyuki Matsunaga, Satoshi Endo, Mio Kobayashi, Akira Ikari, Ayano Yonezawa
Publikováno v:
The Journal of Biochemistry. 171:97-108
Cisplatin (CDDP) is widely prescribed for the treatment of various cancers including bladder cancers, whereas its clinical use for breast cancer chemotherapy is restricted owing to easy acquisition of the chemoresistance. Here, we established a highl
Publikováno v:
J Biochem
Acinetobacter baumannii is an insidious emerging nosocomial pathogen that has developed resistance to all available antimicrobials, including the last resort antibiotic, colistin. Colistin resistance often occurs due to mutations in the PmrAB two-com
Publikováno v:
The Journal of Biochemistry. 170:587-592
Advanced glycation end-products (AGEs) are formed when proteins react with carbonyl compounds, and they gradually accumulate with age. However, AGE accumulation with ageing is not fully understood because longevity studies in mammals are time-consumi
Publikováno v:
Glycobiology. 31:520-523
It is generally known that hyaluronic acid (HA) is a biocompatible and biodegradable glycosaminoglycan distributed widely throughout epithelial, connective and neural tissues. HA is one of the chief components of the extracellular matrix. Lack of imm
Autor:
Jiaqi Yuan, Yue Fei
Publikováno v:
The Journal of Biochemistry. 170:25-31
Lidocaine is a commonly used drug to alleviate neuropathic pain (NP). This work aims to investigate the mechanism of lidocaine in alleviating NP. Chronic constriction injury (CCI) rats were established by surgery to induce NP. We observed the mechani
Publikováno v:
The Journal of Biochemistry. 169:485-489
Deleting the gene for small RNA GcvB in Escherichia coli was found to increase the sensitivity to several aminoglycoside antibiotics, such as neomycin, streptomycin, kanamycin, kasugamycin and spectinomycin, at low concentrations. GcvB, conserved in
Autor:
Maria Ghafourian Hesami, Esmaeil Samizadeh, Reza Eshrati, Saeed Gudarzi, Mahvash Jafari, Afshen Nazari
Publikováno v:
The Journal of Biochemistry. 169:337-350
Taraxacum syriacum (TS) with natural antioxidant and pharmacological activities may be considered for treatment of oxidative stress induced by acetaminophen (APAP). The aim of this study was to evaluate the ameliorative effects of the ethanol extract
Autor:
Anders Rehfeld
Publikováno v:
Molecular Human Reproduction. 26:816-824
The sperm-specific Ca2+ channel CatSper (cation channel of sperm) is vital for male fertility. Contradictory findings have been published on the regulation of human CatSper by the endogenous steroids estradiol, testosterone and hydrocortisone, as wel