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Publikováno v:
J Antimicrob Chemother
Background The cyclic anionic lipopeptide daptomycin is used in the treatment of severe infections caused by Gram-positive pathogens, including MRSA. Daptomycin resistance, although rare, often results in treatment failure. Paradoxically, in MRSA, da
Autor:
Michael Constantine, Romualdo Barroso-Sousa, Tianyu Li, Eric P. Winer, Meredith Faggen, Antonio Di Meglio, Nabihah Tayob, Harold J. Burstein, Caroline Block, Natalie Faye Sinclair, Rebecca Rees, Nan Lin, Ann H. Partridge, Ines Vaz-Luis, Sara M. Tolaney, Jiani Hu, Michael J. Hassett, Jose Pablo Leone, Lindsey Milisits, Frederick Briccetti, Lorenzo Trippa, Adrienne G. Waks
Publikováno v:
The Oncologist
Background In early trials, hypersensitivity reactions (HSRs) to paclitaxel were common, thus prompting the administration of antihistamines and corticosteroids before every paclitaxel dose. We tested the safety of omitting corticosteroids after cycl
Autor:
Teresa R Gray, Crystal Arndt
Publikováno v:
Journal of Analytical Toxicology. 46:e73-e77
Phenibut, a GABAB agonist structurally similar to baclofen, is not approved for medical use in the USA but is available through internet suppliers for recreational use. Calls to poison control centers for phenibut have increased over the last 5 years
Autor:
Supanat Burinkul, Punkavee Tuntiviriyapun, Ammarin Suwan, Sorawit Wainipitapong, Krasean Panyakhamlerd
Publikováno v:
The Journal of Sexual Medicine. 18:1299-1307
Background Spironolactone and cyproterone acetate are commonly used in feminizing hormone therapy to achieve the goal of female range testosterone level; however, the data on the efficacy comparing between these two anti-androgens are scarce. Aim To
Autor:
Tugba Bal Tastan, Rustem Anil Ugan, Duygu Kose, Zekai Halici, Elif Cadirci, Harun Un, Aysenur Kahramanlar
Publikováno v:
Journal of Pharmacy and Pharmacology. 73:1302-1309
Objectives We investigated, the effects of aprepitant (APRE) on the lung tissues of rats with an experimental polymicrobial sepsis model (CLP: cecal ligation and puncture) biochemically, molecularly and histopathologically. Methods A total of 40 rats
Autor:
Hiroki Inoue, Nobuhiko Itami, Kimiko Inoue, Atsuo Ogura, Norikazu Nishino, Kei Miyamoto, Akihiro Ito, Eiji Mizutani, Teruhiko Wakayama, Minoru Yoshida, Jin-Moon Kim, Satoshi Kamimura, Narumi Ogonuki, Shunya Ihashi
Publikováno v:
Biology of Reproduction
In mammalian cloning by somatic cell nuclear transfer (SCNT), the treatment of reconstructed embryos with histone deacetylase (HDAC) inhibitors improves efficiency. So far, most of those used for SCNT are hydroxamic acid derivatives—such as trichos
Autor:
Daizo Kaito, Mototsugu Shimokawa, Takenobu Gomyo, Jun Hakamata, Akio Suzuki, Takahiro Arai, Yasushi Ohno, Chiemi Hirose, Norihiko Funaguchi, Chizuru Sakai, Hitoshi Kawazoe, Koichi Minato, Hiroyuki Okura, Hisao Imai, Hirotoshi Iihara, Yukiyoshi Fujita, Shinnosuke Ikemura, Mie Kotake
Publikováno v:
The Oncologist
Background Olanzapine is an inexpensive and durable agent for the treatment of chemotherapy‐induced nausea and vomiting and is also superior to neurokinin‐1 receptor antagonists in the control of nausea. This study aimed to investigate the effica
Autor:
Whitney Walkowski, Hamilton E. Farris, Caitlin E. Leslie, Michael J. Ryan, Robert F. Rosencrans, Nicolas G. Bazan, William C. Gordon
Publikováno v:
Integrative and Comparative Biology
Although mate searching behavior in female túngara frogs (Physalaemus pustulosus) is nocturnal and largely mediated by acoustic cues, male signaling includes visual cues produced by the vocal sac. To compensate for these low light conditions, visual
Autor:
Florian Scotté, Luigi Celio, Yolanda Escobar, Alessandra Franceschetti, Karin Jordan, Danielle Bell, Matti Aapro, Richard Berman
Publikováno v:
Oncologist
Background Guideline-recommended antiemetic prophylaxis improves nausea and vomiting control in most patients undergoing chemotherapy. Multinational Association of Supportive Care in Cancer/European Society for Medical Oncology (MASCC/ESMO) antiemeti
Autor:
Yuhong Luo, Shogo Takahashi, Frank J. Gonzalez, Haiping Hao, Nana Yan, Hong Wang, Tingting Yan, Guangji Wang, Min Zhao, Kristopher W. Krausz, Tomoki Yagai
Publikováno v:
Toxicol Sci
The idiosyncratic characteristics and severity of acetaminophen (APAP) overdose-induced hepatotoxicity render identifying the predisposing factors and mechanisms of APAP-induced liver toxicity necessary and urgent. Farnesoid X receptor (FXR) controls