Zobrazeno 1 - 10
of 112
pro vyhledávání: ''
Autor:
Seiji Nakamura, Masafumi Moriyama, Yun Zhang, Takeshi Ichinohe, Yuji Motoi, Kensuke Miyake, Ryutaro Fukui, Takuma Shibata, Ryota Sato, Shin-ichiroh Saitoh, Katsuhiro Furusho
Publikováno v:
International Immunology. 31:167-173
Toll-like receptor 8 (TLR8), a sensor for pathogen-derived single-stranded RNA (ssRNA), binds to uridine (Uri) and ssRNA to induce defense responses. We here show that cytidine (Cyd) with ssRNA also activated TLR8 in peripheral blood leukocytes (PBLs
Autor:
Triantafyllos Chavakis, Graeme Eisenhofer, Stefan R. Bornstein, M Ehrhart-Bornstein, Ian Levenfus, Steve W. Poser, Jimmy Masjkur, Nan Qin, Sven Lange, Vladimir Vukicevic, Carina Arps-Forker, Andreas Androutsellis-Theotokis
Publikováno v:
Stem Cells Translational Medicine. 3:801-808
We present a method to efficiently culture primary chromaffin progenitors from the adult bovine adrenal medulla in a defined, serum-free monolayer system. Tissue is dissociated and plated for expansion under support by the mitogen basic fibroblast gr
Autor:
Miriam C. Poirier, Eunwoo Shim, James B. Mitchell, Yongmin Liu, Phuonggiang Nguyen, Alexander T. Gibbons
Publikováno v:
Toxicological Sciences. 139:133-141
Nucleoside reverse transcriptase inhibitors (NRTIs), essential components of combinational therapies used for treatment of human immunodeficiency virus-1, damage heart mitochondria. Here, we have shown mitochondrial compromise in H9c2 rat cardiomyocy
Autor:
Robert J. Linhardt, Payel Datta, Jeffrey D. Esko, Bo Yang, Jong Youn Baik, Trent R. Gemmill, Guoyun Li, Charles A. Glass, Susan T. Sharfstein, Leyla Gasimli
Publikováno v:
Glycobiology, vol 24, iss 3
Heparin (HP), an important anticoagulant polysaccharide, is produced in a complex biosynthetic pathway in connective tissue-type mast cells. Both the structure and size of HP are critical factors determining the anticoagulation activity. A murine mas
Autor:
Shuhei Takahashi, Hisashi Johno, Shotaro Nakajima, Masanori Kitamura, Tatsuya Yoshitomi, Liubao Gu
Publikováno v:
Toxicological Sciences. 134:345-354
In this study, we show that cordycepin (3'-deoxyadenosine), a major nucleoside isolated from Cordyceps species, attenuates genotoxic stress-induced senescence. Etoposide- or doxorubicin-treated cells exhibited senescent morphology, growth arrest, and
Publikováno v:
Journal of Pharmacy and Pharmacology. 65:310-316
Objectives This work aimed to assess the matrix metalloproteinase inhibitory and related pharmacological actions of 20(R)-ginsenoside Rh2 (20(R)-Rh2) in cultured macrophages and keratinocytes. Methods In-vitro anti-inflammatory activity of 20(R)-Rh2
Publikováno v:
Journal of Biochemistry. 152:285-292
Emerging evidence indicates that vitamin D (VD) is an important modulator of brain development and function. To investigate whether VD modulates neurosteroid biosynthesis in neural cells, we investigated the effect of VD(3) on steroidogenic gene expr
Autor:
Guy N. Brock, C. William Helm, Teresa W.-M. Fan, Clarisse S. Muenyi, Allan R. Pinhas, J. Christopher States
Publikováno v:
Toxicological Sciences. 127:139-149
Epithelial ovarian cancer (EOC) is the leading cause of gynecological cancer death in the United States. Cisplatin is a DNA damaging agent initially effective against EOC but limited by resistance. P53 plays a critical role in cellular response to DN
Publikováno v:
Biology of Reproduction. 83:1056-1063
In both male and female germ cells of mice, retinoic acid (RA) is a meiosis-inducing factor. In the present study, we used a germ cell culture system to examine the direct effects of RA on meiotic initiation in male germ cells at the stage when they
Publikováno v:
Journal of Biochemistry. 148:139-148
Lipocalin-type prostaglandin D synthase (L-PGDS) catalyses the formation of prostaglandin D(2) (PGD(2)) and also functions as a transporter for lipophilic ligands, including all-trans retinoic acid (RA). Here, we show that human epidermal melanocytes