Zobrazeno 1 - 10
of 335
pro vyhledávání: ''
Autor:
Stefan Bittner, Alexander M. Herrmann, Frauke Zipp, Sarah Lauks, Sven G. Meuth, Lisanne Korn, Martin Diebold, Felix Luessi, Simone König, Marie Liebmann, Andreas Schulte-Mecklenbeck, Claudia Janoschka, Nicholas Schwab, Heinz Wiendl, Stephan Schmidt, Stjepana Kovac, Tilman Schneider-Hohendorf, Stefanie Albrecht, Catharina C. Gross, Maria Eveslage, Tanja Kuhlmann, Tobias Derfuss, Luisa Klotz, Brigitte Wildemann
Publikováno v:
Brain. 144:3126-3141
Dimethyl fumarate, an approved treatment for relapsing-remitting multiple sclerosis, exerts pleiotropic effects on immune cells as well as CNS resident cells. Here, we show that dimethyl fumarate exerts a profound alteration of the metabolic profile
Autor:
Jinghe Zhang, Hong Zhao, Binqing Fu, Peng Peng, Zhigang Tian, Dongyao Wang, Dong Wang, Yiqing Shen, Xiaodong Mei, Qi Zhu, Xiaohu Zheng, Min Huang, Xianxiang Chen, Guiqiang Wang, Wuxiang Guan, Yonggang Zhou
Publikováno v:
Journal of Molecular Cell Biology
Background: The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has gradually become a global public health crisis. Some patients who have recovered from COVID-19 subsequently tested positi
Autor:
Adam Godzik, Jiang Li, Xinru Qiu, Aarti Mittal, Meera G. Nair, Lukasz Jaroszewski, Jeff Bonenfant, Walter Klein
Publikováno v:
J Leukoc Biol
Systemic infections, especially in patients with chronic diseases, may result in sepsis: an explosive, uncoordinated immune response that can lead to multisystem organ failure with a high mortality rate. Patients with similar clinical phenotypes or s
Autor:
Haotian Cao, Daning Lu, Masaharu Hazawa, Xin Xu, Yongsheng Huang, Xiu-E Xu, Tiago C. Silva, Qian Yang, Yanbing Ding, Dong Yin, En-Min Li, Lehang Lin, Yueyuan Zheng, Li Peng, Li-Yan Xu, Benjamin P. Berman
Publikováno v:
Nucleic Acids Research
To reconstruct systematically hyperactive transcription factor (TF)-dependent transcription networks in squamous cell carcinomas (SCCs), a computational method (ELMER) was applied to 1293 pan-SCC patient samples, and 44 hyperactive SCC TFs were ident
Autor:
Christelle Le Dantec, Cristina Adela Iuga, Ioana-Ecaterina Pralea, Melanie Cornen, Wesley H. Brooks, Jacques-Olivier Pers, Hussam Saad, Tiffany Bergot, Adrian Tempescul, Anne Bordron, Delphine G. Bernard, Jean-Christophe Ianotto, Cristina Bagacean, Mihnea Zdrenghea, Christian Berthou, Yves Renaudineau
Publikováno v:
Journal of Leukocyte Biology
Journal of Leukocyte Biology, 2022, 111 (2), pp.313-325. ⟨10.1002/JLB.4HI0620-392R⟩
Journal of Leukocyte Biology, 2022, 111 (2), pp.313-325. ⟨10.1002/JLB.4HI0620-392R⟩
Chronic lymphocytic leukemia (CLL) is characterized by significant biologic and clinical heterogeneity. This study was designed to explore CLL B-cells’ proteomic profile in order to identify biologic processes affected at an early stage and during
Autor:
Xihua Lin, Daniel Turunen Eserberg, Linghua Zhu, Erik Matro, Yi-ping Zhu, Fang Wu, Nan Zhang, Weiwei Gui
Publikováno v:
Journal of Molecular Cell Biology
Extreme hypoxia is among the most prominent pathogenic features of pancreatic cancer (PC). Both the long non-coding RNA (lncRNA) plasmacytoma variant translocation 1 (PVT1) and hypoxic inducible factor-1α (HIF-1α) are highly expressed in PC patient
Autor:
Patrycja Hoffmann, Neal S. Young, Amanda K. Ombrello, Shouguo Gao, Carrie Diamond, Naoki Watanabe, Zhijie Wu, Sai Batchu, Lemlem Alemu, Diego Quinones Raffo, Sachiko Kajigaya, Deborah L. Stone
Publikováno v:
Journal of Leukocyte Biology. 110:409-424
Deficiency of adenosine deaminase 2 (DADA2) is a rare autosomal recessive disease caused by loss-of-function variants in the ADA2 gene. DADA2 typically presents in childhood and is characterized by vasculopathy, stroke, inflammation, immunodeficiency
Autor:
Yiyuan Xia, Keqiang Ye, Xia Liu, Yinan Yao, Thorsten Müller, Zhi-Hao Wang, Seong Su Kang, Yi E. Sun
Publikováno v:
Brain
Amyloid-β precursor protein (APP) is sequentially cleaved by secretases and generates amyloid-β, the major components in senile plaques in Alzheimer’s disease. APP is upregulated in human Alzheimer’s disease brains. However, the molecular mecha
Autor:
Alexis Nazareno Campetelli, Melisa Micaela Balach, Cesar Horacio Casale, Tamara Muhlberger, Verónica Silvina Santander, Noelia Edith Monesterolo, Carlos Gaston Bisig
Publikováno v:
The Journal of Biochemistry. 169:731-745
Plasma membrane tubulin is an endogenous regulator of P-ATPases and the unusual accumulation of tubulin in the erythrocyte membrane results in a partial inhibition of some their activities, causing hemorheological disorders like reduced cell deformab
Autor:
Réda Malek Hamidi, Rachida Khellafi, Ahmed Kadi, Reda Djidjik, Fawzi Derrar, Belgacem Mihi, Sarah Yasmine Rahali, Lilya Berkani, Asma Djidjeli, Ismahane Berkane, Dalila Mekideche, Zineb Larab, Lylia Kheddouci, Lydia Lamara Mahammad, A. Kheliouen, Brahim Belaid, Soraya Ayoub, Wafa Sayah, Fatma Merah, Mourad Ouali, Ines Allam, Merzak Gharnaout, Nouzha Zhor Lazli
Publikováno v:
Journal of Leukocyte Biology
The immune system plays a crucial role in the response against severe acute respiratory syndrome coronavirus 2 with significant differences among patients. The study investigated the relationships between lymphocyte subsets, cytokines, and disease ou