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Publikováno v:
Biology of Reproduction. 105:1355-1364
Bisphenol A (BPA) is one of the most investigated compound as a suspected endocrine disrupting chemical. It has been found at nM concentrations in the maternal serum, cord serum, and amniotic fluid and also permeates placental tissues. Attempts are b
Autor:
Yi Zheng, Linlin Zhang, Qian Sang, Xiaoli Gong, Hongting Zheng, Hua Qu, Xin Xiong, Yongling Lu, Yuren Wang, Xiufei Liu, Bangliang Huang
Publikováno v:
Journal of Molecular Cell Biology
The activity of proteinase is reported to correlate with the development and progression of nonalcoholic fatty liver disease (NAFLD). Puromycin-sensitive aminopeptidase (PSA/NPEPPS) is an integral nontransmembrane enzyme that functions to catalyze th
Autor:
Sathish Kumar, Jay S. Mishra
Publikováno v:
Biol Reprod
Preeclampsia is a pregnancy-related hypertensive disorder with unclear mechanisms. While hypersensitivity to angiotensin II via vasoconstrictive angiotensin type-1 receptor (AT1R) is observed in preeclampsia, the importance of vasodilatory angiotensi
Autor:
Diane M. Duffy, Linah Al-Alem, James W. Akin, Mats Brännström, Thomas E. Curry, Ketan Shrestha, Kathy Rosewell, Misung Jo, Muraly Puttabyatappa, Yohan Choi
Publikováno v:
Biol Reprod
Neurotensin (NTS) is a tridecapeptide that was first characterized as a neurotransmitter in neuronal cells. The present study examined ovarian NTS expression across the periovulatory period in the human and the rat. Women were recruited into this stu
Publikováno v:
Journal of Molecular Cell Biology
Hepatic gluconeogenesis is the central pathway for glucose generation in the body. The imbalance between glucose synthesis and uptake leads to metabolic diseases such as obesity, diabetes, and cardiovascular diseases. Small leucine zipper protein (sL
Autor:
Anders Rehfeld
Publikováno v:
Molecular Human Reproduction. 26:816-824
The sperm-specific Ca2+ channel CatSper (cation channel of sperm) is vital for male fertility. Contradictory findings have been published on the regulation of human CatSper by the endogenous steroids estradiol, testosterone and hydrocortisone, as wel
Glycogen in the uterus and fallopian tubes is an important source of glucose during early pregnancy†
Autor:
Matthew Dean
Publikováno v:
Biology of Reproduction. 101:297-305
Pregnancy loss is common during the peri-implantation period in mammals when glucose is required for both embryonic development and decidualization of the endometrium. As the uterus cannot synthesize glucose, all glucose must come directly from mater
Autor:
Shigeru Shibata
Publikováno v:
American Journal of Hypertension. 32:607-613
The recent advances in genetics and molecular biology have resulted in the characterization of key components that critically regulate renal NaCl transport and blood pressure. Pendrin is a Cl−/HCO3− exchanger that is highly expressed in thyroid,
Autor:
Cameron Griffin, Brian F. Zamarron, Gabriel Martinez-Santibanez, Kanakadurga Singer, Jennifer B. DelProposto, Robert W. O’ Rourke, Carey N. Lumeng, Lindsey A. Muir, Hannah R. Lucas, Lynn M. Geletka, Samadhi Kiridena
Publikováno v:
Journal of Leukocyte Biology. 103:615-628
Obesity-related changes in adipose tissue leukocytes, in particular adipose tissue macrophages (ATMs) and dendritic cells (ATDCs), are implicated in metabolic inflammation, insulin resistance, and altered regulation of adipocyte function. We evaluate
Publikováno v:
MHR: Basic science of reproductive medicine. 23:786-802
Study question Does coumestrol inhibit proliferation of human placental choriocarcinoma cells? Summary answer Coumestrol promotes cell death in the choriocarcinoma cells by regulating ERK1/2 MAPK and JNK MAPK signaling pathways and through disruption