Zobrazeno 1 - 10
of 112
pro vyhledávání: ''
Autor:
Yaoyong Li, Samantha Carrera, Andrew D. Sharrocks, Karol Nowicki-Osuch, Shen Hsi Yang, Syed Murtuza Baker, David G. Spiller, Amanda O'Donnell
Publikováno v:
Nucleic Acids Research
Carrera, S, O'Donnell, A, Li, Y, Nowicki-Osuch, K, Yang, S-H, Baker, S M, Spiller, D & Sharrocks, A 2021, ' Complexities in the role of acetylation dynamics in modifying inducible gene activation parameters. ', Nucleic Acids Res, vol. 49, no. 22, pp. 12744–12756 . https://doi.org/10.1093/nar/gkab1176
Carrera, S, O'Donnell, A, Li, Y, Nowicki-Osuch, K, Yang, S-H, Baker, S M, Spiller, D & Sharrocks, A 2021, ' Complexities in the role of acetylation dynamics in modifying inducible gene activation parameters. ', Nucleic Acids Res, vol. 49, no. 22, pp. 12744–12756 . https://doi.org/10.1093/nar/gkab1176
High levels of histone acetylation are associated with the regulatory elements of active genes, suggesting a link between acetylation and gene activation. We revisited this model, in the context of EGF-inducible gene expression and found that rather
Publikováno v:
Stem Cells. 39:429-442
Tissues and cells derived from pluripotent stem cells (PSC) are likely to become widely used in disease modeling, drug screening, and regenerative medicine. For these applications, the in vitro PSC differentiation process must be elaborately investig
Autor:
Myriam Gorospe, Jennifer L. Martindale, Ming-Wen Chang, Dimitrios Tsitsipatis, Jen-Hao Yang, Supriyo De, Xiaoling Yang, Rachel Munk, Poonam R. Pandey, Kotb Abdelmohsen
Publikováno v:
Nucleic Acids Res
Long noncoding (lnc)RNAs potently regulate gene expression programs in physiology and disease. Here, we describe a key function for lncRNA OIP5-AS1 in myogenesis, the process whereby myoblasts differentiate into myotubes during muscle development and
Publikováno v:
Chem Senses
Olfactory sensory neurons (OSNs) are bipolar neurons, unusual because they turn over continuously and have a multiciliated dendrite. The extensive changes in gene expression accompanying OSN differentiation in mice are largely known, especially the t
Autor:
Hongwei Wang, Xiangguo Liu, B Li, Kundi Zhang, Ning Du, Lichuan Gu, Shun Yao, Hongjie Dong, Min Chen, Jingwen Li, Nannan Song, Sujuan Xu, Honghai Zhang, Fengyu Zhang
Publikováno v:
Nucleic Acids Research
Iron is essential for all bacteria. In most bacteria, intracellular iron homeostasis is tightly regulated by the ferric uptake regulator Fur. However, how Fur activates the iron-uptake system during iron deficiency is not fully elucidated. In this st
Autor:
Zachary Kraus, Pei-Jyun Liao, Jessica Dement-Brown, Ilya Mazo, Mate Tolnay, Frederick Mills, Sean P. Fitzsimmons, Huifang Li
Publikováno v:
International Immunology. 32:755-770
Atypical memory B cells accumulate in chronic infections and autoimmune conditions, and commonly express FCRL4 and FCRL5, respective IgA and IgG receptors. We characterized memory cells from tonsils on the basis of both FCRL4 and FCRL5 expression, de
Autor:
Stephen W. Fesik, Dai H. Chung, William P. Tansey, David K. Flaherty, Alissa D. Guarnaccia, Eric J. Rellinger, April M. Weissmiller, Shelly L. Lorey, Brittany K. Matlock, Erin R. Aho, Chase M Woodley, Gregory C. Howard, Qi Liu, Audra F Bryan, Jing Wang
Publikováno v:
Nucleic Acids Research
WDR5 is a highly-conserved nuclear protein that performs multiple scaffolding functions in the context of chromatin. WDR5 is also a promising target for pharmacological inhibition in cancer, with small molecule inhibitors of an arginine-binding pocke
Autor:
Helena Libalova, Lenka Šmerdová, Jana Svobodová, Alois Kozubík, Jiřina Procházková, Martin Krkoška, Markéta Kabátková, Miroslav Machala, Jiří Kléma, Jan Vondráček, Jan Topinka
Publikováno v:
Toxicological Sciences. 172:368-384
The aryl hydrocarbon receptor (AhR) activation has been shown to alter proliferation, apoptosis, or differentiation of adult rat liver progenitors. Here, we investigated the impact of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-mediated AhR activation
Autor:
Xinyue Wei, Dapeng Liang, Siqi Zhao, Haidong Zhao, Baohui Zhu, Qi Wang, Shuai Hou, Dajun Qu, Liye Zhang, Misbah Khan, Haixin Lei, Wei Guo, Jiaojiao Hao, Yue Li, Wei Tang, Weijie Wang, Qian Zhang, Sikandar Azam
Publikováno v:
Nucleic Acids Research
XAB2 is a multi-functional protein participating processes including transcription, splicing, DNA repair and mRNA export. Here, we report POLR2A, the largest catalytic subunit of RNA polymerase II, as a major target gene down-regulated after XAB2 dep
Publikováno v:
Human Molecular Genetics
Jeffery, N, Richardson, S, Chambers, D, Morgan, N G & Harries, L W 2019, ' Cellular stressors may alter islet hormone cell proportions by moderation of alternative splicing patterns ', Human Molecular Genetics, vol. 28, no. 16, pp. 2763-2774 . https://doi.org/10.1093/hmg/ddz094
Jeffery, N, Richardson, S, Chambers, D, Morgan, N G & Harries, L W 2019, ' Cellular stressors may alter islet hormone cell proportions by moderation of alternative splicing patterns ', Human Molecular Genetics, vol. 28, no. 16, pp. 2763-2774 . https://doi.org/10.1093/hmg/ddz094
Changes to islet cell identity in response to type 2 diabetes (T2D) have been reported in rodent models, but are less well characterized in humans. We assessed the effects of aspects of the diabetic microenvironment on hormone staining, total gene ex