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Autor:
Susan C. Menzies, Jessica Leung, Mahdis Monajemi, Rym Ben-Othman, Tobias R. Kollmann, Laura M. Sly, Bing Cai, Shera Fisk, Yvonne C. F. Pang, Jacob Rozmus
Publikováno v:
Journal of Leukocyte Biology. 106:863-877
This study tested the hypothesis that mucosa associated lymphoid tissue 1 (Malt1) deficiency causes osteoporosis in mice by increasing osteoclastogenesis and osteoclast activity. A patient with combined immunodeficiency (CID) caused by MALT1 deficien
Autor:
Meriem Garfa-Traore, Emilie Dambroise, Ludovic Martin, Nabil Kaci, Valentin Estibals, Laurence Legeai-Mallet, Nicolas Goudin, Catherine Benoist-Lasselin
Publikováno v:
Human Molecular Genetics. 27:1-13
Fibroblast growth factor receptor 3 (FGFR3) gain-of-function mutations cause dwarfisms, including achondroplasia (ACH) and thanatophoric dysplasia (TD). The constitutive activation of FGFR3 disrupts the normal process of skeletal growth. Bone-growth
Autor:
Talal Zahoor, Samuel Achilefu, Reed Mitchell, Young Cho, Lew C. Schon, Jeffrey Loube, Jeremy Molligan, Zijun Zhang
Publikováno v:
Stem Cells Translational Medicine, Vol 5, Iss 6, Pp 745-753 (2016)
By using surgical mouse models, this study investigated how the tissue environment influences the osteogenic potential of muscle progenitors (m-progenitors) and potentially contributes to heterotopic ossification (HO). Injury was induced by clamping
Autor:
Roberta Squecco, Gianni Forti, Gabriella B. Vannelli, Daniele Guasti, Benedetta Mazzanti, Eglantina Idrizaj, Michaela Luconi, José M. Gallego-Escuredo, Alessandra Di Franco, Daniele Bani, Francesc Villarroya, Francesca Rossi
Publikováno v:
Stem cells (Dayt. Ohio) 34 (2016): 1679–1691. doi:10.1002/stem.2336
info:cnr-pdr/source/autori:Di Franco, Alessandra; Guasti, Daniele; Squecco, Roberta; Mazzanti, Benedetta; Rossi, Francesca; Idrizaj, Eglantina; Gallego-Escuredo, Jose M.; Villarroya, Francesc; Bani, Daniele; Forti, Gianni; Vannelli, Gabriella Barbara; Luconi, Michaela/titolo:Searching for Classical Brown Fat in Humans: Development of a Novel Human Fetal Brown Stem Cell Model/doi:10.1002%2Fstem.2336/rivista:Stem cells (Dayt. Ohio)/anno:2016/pagina_da:1679/pagina_a:1691/intervallo_pagine:1679–1691/volume:34
info:cnr-pdr/source/autori:Di Franco, Alessandra; Guasti, Daniele; Squecco, Roberta; Mazzanti, Benedetta; Rossi, Francesca; Idrizaj, Eglantina; Gallego-Escuredo, Jose M.; Villarroya, Francesc; Bani, Daniele; Forti, Gianni; Vannelli, Gabriella Barbara; Luconi, Michaela/titolo:Searching for Classical Brown Fat in Humans: Development of a Novel Human Fetal Brown Stem Cell Model/doi:10.1002%2Fstem.2336/rivista:Stem cells (Dayt. Ohio)/anno:2016/pagina_da:1679/pagina_a:1691/intervallo_pagine:1679–1691/volume:34
The potential therapeutic applications of targeting brown adipose tissue open new clinical avenues in fighting against metabolic pathologies. However, due to the limited extension in adult humans of brown depots, which are dramatically reduced after
Autor:
Yoko Ono, Yuki Nagahara, Hideaki Hara, Chizuru Kawase, Kazuki Ohuchi, Kazuhiro Tsuruma, Zenichiro Kato, Hideo Kaneko, Yuya Tamai, Junko Seki, Michinori Funato, Yasuhiro Noda, Shiori Ando, Tsubasa Kameyama, Masamitsu Shimazawa
Publikováno v:
Stem Cells Translational Medicine. 5:152-163
Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disorder characterized by the degeneration of spinal motor neurons. This disease is mainly caused by mutation or deletion of the survival motor neuron 1 (SMN1) gene. Currently, no
Autor:
Kenneth R. Boheler, Yu Huang, Z. C. Li, Ellen Poon, Xiaoqiang Yao, Peng Zhang, Y. Wang, C. W. Kong, R. A. Li
Publikováno v:
Stem Cells. 33:2973-2984
Cardiac hypertrophy is an abnormal enlargement of heart muscle. It frequently results in congestive heart failure, which is a leading cause of human death. Previous studies demonstrated that the nitric oxide (NO), cyclic GMP (cGMP), and protein kinas
Autor:
Thomas C. Schulz
Publikováno v:
Stem Cells Translational Medicine. 4:927-931
The cellular component of ViaCyte's VC-01 combination product for type 1 diabetes, pancreatic endoderm cells (PEC-01) derived from CyT49 human embryonic stem cells, matures after transplantation and functions to regulate blood glucose in rodent model
Autor:
Beom Hee Lee, Dong-Kyu Kim, Yong-Mahn Han, Seung Kyoon Kim, Kyu-Min Han, Jung Yun Choi, Cheol-Hee Kim, Kyu-Seok Hwang, Han-Wook Yoo, Ilkyun Im
Publikováno v:
Stem Cells. 33:1447-1455
Cardio-facio-cutaneous (CFC) syndrome is a developmental disorder caused by constitutively active ERK signaling manifesting mainly from BRAF mutations. Little is known about the role of elevated ERK signaling in CFC syndrome during early development.
Publikováno v:
Stem Cells. 33:133-145
Endothelial glucose transporter 1 (GLUT1) is a definitive and diagnostic marker for infantile hemangioma (IH), a vascular tumor of infancy. To date, GLUT1-positive endothelial cells in IH have not been quantified nor directly isolated and studied. We
Autor:
Chai K. Lim, Christopher Vidal, Gustavo Duque, Brigitte Santner-Nanan, Helen J. Ball, Nicholas H. Hunt, Gilles J. Guillemin, Wei Li, Ralph Nanan
Publikováno v:
Stem Cells. 33:111-121
The mechanisms involved in the anabolic effect of interferon gamma (IFNγ) on bone have not been carefully examined. Using microarray expression analysis, we found that IFNγ upregulates a set of genes associated with a tryptophan degradation pathway