Zobrazeno 11 - 20
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Autor:
Jessica J Jowais, Marina Rieder, Lucilla Giammarino, Katja E. Odening, Michael Brunner, Christoph Bode, Sara I. Liin, Alessandro Castiglione, Manfred Zehender, Stefanie Perez-Feliz, Eike M. Wülfers, Gideon Koren, Hans Peter Larsson, Tibor Hornyik, István Baczkó, Iask Edler, András Varró, Zsuzsanna Bősze
Publikováno v:
Europace
Aim Long QT syndrome (LQTS) is a cardiac channelopathy predisposing to ventricular arrhythmias and sudden cardiac death. Since current therapies often fail to prevent arrhythmic events in certain LQTS subtypes, new therapeutic strategies are needed.
Publikováno v:
Journal of Burn Care & Research. 43:1-8
The goal of this study was to determine what effect obese body weight and a burn injury can have on the metabolism of glucose and lipids in rats. We used a 3 * 3 factorial model design to provide basic glucose and lipid metabolic data characterizing
Publikováno v:
Journal of Applied Microbiology. 132:1370-1383
Aims Pre-eclampsia (PE) affects pregnant patients worldwide, but there is no effective treatment for this condition. We aimed to explore the effect of sodium butyrate (NaB) on PE. Methods and results In this study, Nω-nitro-L-arginine methyl ester h
Autor:
Fabio Demontis, Liam C. Hunt
Publikováno v:
J Gerontol A Biol Sci Med Sci
Metabolic adaptations occur with aging but the significance and causal roles of such changes are only partially known. In Drosophila, we find that skeletal muscle aging is paradoxically characterized by increased readouts of glycolysis (lactate, NADH
Autor:
Xiaoli Luo, Pedro A. Jose, Caiyu Chen, Xue Gong, Cong Lan, Cheng Yu, Cuimei Hu, Chao Fan, Zaicheng Xu, Chunyu Zeng, Jialiang Wang, Hao Luo
Publikováno v:
Cardiovasc Res
Aims Exposure to maternal diabetes is associated with increased prevalence of hypertension in the offspring. The mechanisms underlying the prenatal programming of hypertension remain unclear. Because endoplasmic reticulum (ER) stress plays a key role
Publikováno v:
Biology of Reproduction. 105:1317-1329
The study investigated the effects of prolonging photoperiod on the synthesis of testosterone and melatonin in roosters, and the effect of melatonin on testosterone synthesis in rooster Leydig cells as well as its molecular mechanisms. We randomly di
Autor:
Yea-Tzy Chen, Meng-Shan Cheng, Hung-Ming Chang, Ting-Yi Renn, Yea-Jyh Chen, Wen-Chieh Liao, Li-You Chen, I. V. Klimenkov, Chi-Te Wang, Nikolay P. Sudakov
Publikováno v:
The Journals of Gerontology: Series A. 77:235-242
Presbyphagia is age-related changes in swallowing function, which imposes a high risk of aspiration in older adults. Considering olfactory stimulation (OS) can influence behavioral activities by modulating neuronal excitability, the present study aim
Autor:
Junki Yano, Hina Shuto, Kiyonori Yamaoka, Hiroaki Terato, Takahiro Kataoka, Norie Kanzaki, Katsumi Hanamoto, Fumihiro Mitsunobu, Akihiro Sakoda, Shota Naoe, Hiroshi Tanaka
Publikováno v:
Journal of Radiation Research
Radon inhalation decreases the level of lipid peroxide (LPO); this is attributed to the activation of antioxidative functions. This activation contributes to the beneficial effects of radon therapy, but there are no studies on the risks of radon ther
Autor:
Nicole Risher, Josephine Sheedy, Hasane Ratni, Zhihua Feng, Xin Zhao, Amal Dakka, Anna Mollin, Catherine Lutz, Karen K. Y. Ling, Ellen Welch, Friedrich Metzger, Marla Weetall, Karen S. Chen, Jana Narasimhan, Nikolai Naryshkin, John D. Baird, Chien-Ping Ko
Publikováno v:
Human Molecular Genetics. 31:82-96
Spinal muscular atrophy (SMA) is caused by the loss of the survival motor neuron 1 (SMN1) gene function. The related SMN2 gene partially compensates but produces insufficient levels of SMN protein due to alternative splicing of exon 7. Evrysdi™ (ri
Publikováno v:
Toxicological Sciences. 183:363-377
Aflatoxin B1 (AFB1) induced intestinal epithelial damage in rodent models, which indicates that long-term exposure to AFB1 may cause chronic gut disorders. In this study, we tested the hypothesis that AFB1-induced adverse effects on gut is mediated b