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Autor:
Takahide Kokumai, Koichi Yano, Yoshiya Ito, Kumihiro Matsuo, Shigeru Suzuki, Atsushi Kobayashi, Akimasa Okuno, Kenji Fujieda, Hiroshi Azuma, Akiko Furuya, Yusuke Tanahashi, Tokuo Mukai, Osamu Ueda
Publikováno v:
European Journal of Endocrinology. 185:1-12
Background POU1F1 encodes both PIT-1α, which plays pivotal roles in pituitary development and GH, PRL and TSHB expression, and the alternatively spliced isoform PIT-1β, which contains an insertion of 26-amino acids (β-domain) in the transactivatio
Publikováno v:
The Journals of Gerontology: Series A. 73:579-587
There is currently a limited amount of literature investigating the age-related changes in eccentric muscle function in vitro. The present study uniquely uses the work loop (WL) technique, to better replicate in vivo muscle function, in the assessmen
Autor:
Zeeshan K, Nasifa Nur, Ravichandran, Elizabeth O. Harrington, Colantuono B, Kaikobad Irani, Youhong Liu, Laura E. Benjamin, Frank W. Sellke, Jun Feng, Abid Mr, Reichert K, Shafique E, Torina A
Publikováno v:
Cardiovascular Research. 113:234-246
Aims There are conflicting reports on the role of reactive oxygen species (ROS) i.e. beneficial vs. harmful, in vascular endothelium. Here, we aim to examine whether duration of exposure to ROS and/or subcellular ROS levels are responsible for the ap
Autor:
Patricia Martínez-Miguel, Alberto Ortiz, Susana López-Ongil, Manuel Rodríguez-Puyol, Diana Medrano-Andrés, Diego Rodríguez-Puyol, Mercedes Griera-Merino
Publikováno v:
Cardiovascular Research. 113:207-221
Aim To analyse the ability of TWEAK to modify the endothelin system, particularly endothelin-1 (ET-1) and endothelin-converting enzyme-1 (ECE-1), studying the intracellular mechanisms implied. TNF-like weak inducer of apoptosis (TWEAK) is a member of
Autor:
Artur Fedorowski, Olle Melander, R. H. Scofield, David C. Kem, Campbell Liles, Taylor A. Murphy, Syed M. Quadri, Richard Sutton, Hongliang Li, Kristi A. Koelsch, Valerie M. Harris, Xichun Yu
Publikováno v:
Europace
Aims Postural tachycardia syndrome (POTS), a common and debilitating cardiovascular disorder, is characterized by an exaggerated heart rate increase during orthostasis and a wide spectrum of adrenergic-related symptoms. To determine the aetiology of
Autor:
Bert Vanheel, Geert Bultynck, Elke Decrock, Benjamin Wacquier, Geneviève Dupont, Kelly Decaluwé, Johan Van de Voorde, Mélissa Bol, Luc Leybaert, Nan Wang, Marijke De Bock, Ashish A. Gadicherla, Harold V.M. van Rijen, Dmitri V. Krysko
Publikováno v:
Cardiovascular Research. 113:195-206
Aims Connexins form gap-junctions (GJs) that directly connect cells, thereby coordinating vascular cell function and controlling vessel diameter and blood flow. GJs are composed of two hemichannels contributed by each of the connecting cells. Hemicha
Publikováno v:
Toxicological Sciences. 154:278-288
Chronic kidney disease is characterized by a progressive and permanent loss of functioning nephrons. In order to compensate for this loss, the remaining functional nephrons undergo significant structural and functional changes. We hypothesize that lu
Autor:
Jennifer J. Schlezinger, Ting Hua Wu, Manuel Flores Molina, Maryse Lemaire, Luis Fernando Negro Silva, Fackson Mwale, Koren K. Mann, Dany Plourde, Alicia M. Bolt, Alexander D. R. Kelly, Michael P. Grant
Publikováno v:
Toxicological Sciences. 150:333-346
Tungsten is a naturally occurring metal that increasingly is being incorporated into industrial goods and medical devices, and is recognized as an emerging contaminant. Tungsten preferentially and rapidly accumulates in murine bone in a concentration
Publikováno v:
Toxicological Sciences. 150:283-291
The effects of Beauvericin (BEA) produced by the fungusBeauveria bassianaandFusariumsp. on neuromuscular transmission and contractility were determined in an isolated neuromuscular mouse hemidiaphragm preparation. BEA (5 µM) significantly inhibits i
Publikováno v:
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 71:1131-1140
The infrapatellar fat pad (IFP) secretes inflammatory mediators in osteoarthritic knees, but the effect of aging on IFP inflammation is unknown. We tested the hypothesis that aging increases basal and interleukin-1β (IL-1β)-stimulated IFP inflammat