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Autor:
Leon Earl Gray, Nicola Evans, Christy S. Lambright, Bethany R. Hannas, Justin M. Conley, Johnathan Furr, Hunter Sampson, Vickie S. Wilson, Paul M. D. Foster
Publikováno v:
Toxicol Sci
Previously, we demonstrated that exposure to some diortho-phthalate esters during sexual differentiation disrupts male reproductive development by reducing fetal rat testis testosterone production (T Prod) and gene expression in a dose-related manner
Autor:
Anushri Somavarapu, Glory Florence Meejuru, Lakshmi Sudeepthi Nissankara Roa, Ravi Chandra Sekhara Reddy Danduga, Phani Kumar Kola
Publikováno v:
Journal of Pharmacy and Pharmacology. 73:522-534
Objectives This study aimed to evaluate the effect of duloxetine (10 and 20 mg/kg) against chronic immobilisation stress (CIS)-induced anxiety, depression, cognitive impairment and neurodegeneration in mice. Methods CIS, 2 h/10 days (11:00 AM–1:00
Autor:
Richard L. Stouffer, Cecily V. Bishop, J.K. Rodrigues, Maralee S. Lawson, Shally N. Wolf, Alison Y. Ting, Fuhua Xu, Jing Xu, Olena Y. Tkachenko
Publikováno v:
Biol Reprod
Insulin-like growth factors (IGFs) are known for their involvement in endocrine and paracrine regulation of ovarian function. Although IGF2 is the predominant circulating and intraovarian form of IGFs in primate species, the stage-specific follicular
Autor:
Lereko Kometsi, Edith Pascale Mofo Mato, Khmera Govender, Peter M. O. Owira, Rajendraparsad Hurchund
Publikováno v:
Journal of Pharmacy and Pharmacology. 72:1394-1404
Objectives Antioxidant and anti-inflammatory properties of naringenin could confer hepatoprotective effects. Methods Chang cells in culture media were maintained at 37°C and treated with increased concentrations of glucose (5.5–50 mm) and/or narin
Autor:
Adam Hargreaves, Rob Wallis, Derek J. Leishman, Louise Leong, Steven Engle, Lorna Ewart, David E. Watson, Kathleen M. Heinz-Taheny, Philip H. Milliken, Nick McMahon, Sarah Kirk, Peter Clements, Mike Aylott, Jean-Pierre Valentin, Magali Guffroy, Renaud Fleurance, Nick Edmunds
Publikováno v:
Toxicological Sciences. 176:224-235
Integrating nonclinical in vitro, in silico, and in vivo datasets holistically can improve hazard characterization and risk assessment. In pharmaceutical development, cardiovascular liabilities are a leading cause of compound attrition. Prior to clin
Publikováno v:
Biology of Reproduction
Biology of Reproduction, Society for the Study of Reproduction, 2020, 102 (6), pp.1290-1305. ⟨10.1093/biolre/ioaa027⟩
Biology of Reproduction, Society for the Study of Reproduction, 2020, 102 (6), pp.1290-1305. ⟨10.1093/biolre/ioaa027⟩
Vaspin, visceral-adipose-tissue-derived serine protease inhibitor, is involved in the development of obesity, insulin resistance, inflammation, and energy metabolism. Our previous study showed vaspin expression and its regulation in the ovary; howeve
Publikováno v:
Journal of Tropical Pediatrics. 66:534-541
Background Hyaline membrane disease contributes majorly to preterm mortality, particularly in the developing world. There are two animal-derived surfactants available in South Africa: poractant-alfa (120 mg/1.5 ml) and beractant (100 mg/4 ml). At equ
Publikováno v:
Journal of Pharmacy and Pharmacology. 72:227-235
Objectives We aimed to investigate the effects of icariside II (ICS II) on myocardial fibrosis in spontaneously hypertensive rats (SHRs) and to explore the possible mechanisms. Methods We used SHRs as animal models, and we administered ICS II (4, 8 o
Autor:
Anna Kakehashi, Hideki Wanibuchi, Takashi Yamaguchi, Michiharu Matsumoto, Masaki Fujioka, Yukari Totsuka, Min Gi, Shoji Fukushima, Kenichi Masumura
Publikováno v:
Mutagenesis. 34:279-287
Quantitative analysis of the mutagenicity and carcinogenicity of the low doses of genotoxic carcinogens present in food is of pressing concern. The purpose of the present study was to determine the mutagenicity and carcinogenicity of low doses of the
Autor:
Marcelo Febo, Marjory Pompilus, Karyn A. Esser, Jean R. Geste, Xiping Zhang, Isaac Wilks, Laura E. O'Dell, Brandon Levin, Adriaan W. Bruijnzeel
Publikováno v:
Nicotine Tob Res
Introduction Tobacco use improves mood states and smoking cessation leads to anhedonia, which contributes to relapse. Animal studies have shown that noncontingent nicotine administration enhances brain reward function and leads to dependence. However