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Publikováno v:
Military Medicine. 174:119-123
The purpose of this investigation is to determine if intraosseous infusion (IO) is a suitable method for the delivery of recombinant human factor VIIa (rFVIIa) during hemorrhagic shock. The measures that were used to evaluate IO delivery suitability
Publikováno v:
Journal of Pharmacy and Pharmacology. 61:229-236
ObjectivesMale hypogonadism is frequently associated with testopathy in patients with type 2 diabetes and in middle-aged males. We hypothesized that abnormal matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in testis have large ro
Publikováno v:
British Journal of Dermatology, 160(1), 54-61. Wiley-Blackwell Publishing Ltd
British Journal of Dermatology, 1, 160, 54-61
British Journal of Dermatology, 1, 160, 54-61
Background: Wet-wrap treatment (WWT) with diluted topical steroids is widely used in atopic dermatitis (AD). Mice with transgenic overexpression of human apolipoprotein C1 (APOC1) in the liver and the skin are not only characterized by hyperlipidaemi
Autor:
Sang-wook Lee, Seung-Hee Ryu, Joon Pio Hong, Soo Young Moon, Sun Rock Moon, Jene Choi, Youn-Joo Yang
Publikováno v:
Journal of Radiation Research. 50:545-552
Irradiation causes the impaired proliferation of cells lining mucosal membranes. Epidermal growth factor (EGF) facilitates proliferation of various skin cells; however, the wound healing effects of EGF on radiation-damaged cells is less well known. T
Publikováno v:
Cardiovascular Research. 81:805-813
Aims Evidence from recent studies suggests that the endocannabinoid system participates in the regulation of lipid metabolism and body composition. We hypothesize that the system is activated by oxidized low-density lipoprotein (oxLDL) and regulates
Autor:
Carl W. White, Sumeet Rana, Mallikarjuna Gu, Rajesh Agarwal, Neera Tewari-Singh, Arttatrana Pal, David J. Orlicky
Publikováno v:
Toxicological Sciences. 108:194-206
Sulfur mustard (HD) is an alkylating and cytotoxic chemical warfare agent, which inflicts severe skin toxicity and an inflammatory response. Effective medical countermeasures against HD-caused skin toxicity are lacking due to limited knowledge of rel
Publikováno v:
Journal of Pharmacy and Pharmacology. 60:1643-1650
The anti-serotonergic effects of parthenolide (PTL) demonstrated in platelets inspired the present psychopharmacological investigation, which employs a battery of rodent behavioural assays of depression. In mice, PTL (0.5-2 mg kg−1) exhibited dose-
Publikováno v:
Journal of Pharmacy and Pharmacology. 60:1601-1607
We report here a novel observation that zolmitriptan induced CYP3A2 in male but not female rats. As part of our research programme to evaluate sex differences in the response to zolmitriptan, we studied the effects of zolmitriptan on CYP3A activity,
Publikováno v:
Cardiovascular Research. 81:750-757
Aim Pentoses are widely abundant in organic food. Thermal treatment of pentoses leads to the formation of norfuraneol (NF). The aim of this study was to show whether NF, which is taken up regularly, for example with cooked food, affects the human end
Publikováno v:
Cardiovascular Research. 82:324-332
Aims Although stimulation with sphingosylphosphorylcholine (SPC) or sphingosine-1-phosphate (S1P) generally leads to similar vascular responses, the contractile patterns and their underlying signalling mechanisms are often distinct. We investigated t