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Publikováno v:
The International Journal of Neuropsychopharmacology; Vol 17
International Journal of Neuropsychopharmacology
International Journal of Neuropsychopharmacology
The gastrointestinal hormone PYY(3-36) is a preferential Y2 neuropeptide Y (NPY) receptor agonist. Recent evidence indicates that PYY(3-36) acts on central dopaminergic pathways, but its influence on dopamine-dependent behaviours remains largely unkn
Autor:
Mary Sue Marty, Adam W. Perala, Shakil A. Saghir, Larry Hammond, James S. Bus, Carol L. Zablotny, Barbara H. Neal, Julie K. Passage
Publikováno v:
Toxicological Sciences
Life-stage-dependent toxicity and dose-dependent toxicokinetics (TK) were evaluated in Sprague Dawley rats following dietary exposure to 2,4-dichlorophenoxyacetic acid (2,4-D). 2,4-D renal clearance is impacted by dose-dependent saturation of the ren
Autor:
Agata Siwek, Mariusz Papp, Magdalena Sowa-Kućma, Bartłomiej Pochwat, Gabriel Nowak, Urszula Doboszewska, Bernadeta Szewczyk, Wojciech Piekoszewski, Piotr Gruca
Publikováno v:
The International Journal of Neuropsychopharmacology. 17:393-405
Recent data suggests that the glutamatergic system is involved in the pathophysiology and treatment of major depressive disorder (MDD) and that the N-methyl-D-aspartate (NMDA) receptor is a potential target for antidepressant drugs. The magnesium ion
Publikováno v:
Toxicological Sciences. 136:205-215
The ability to anchor chemical class-based gene expression changes to phenotypic lesions and to describe these changes as a function of dose and time informs mode-of-action determinations and improves quantitative risk assessments. Previous global ex
Publikováno v:
Journal of Pharmacy and Pharmacology. 65:1488-1499
Objectives The G protein-coupled oestrogen receptor-1 (GPER-1) agonist G1 induces endothelium-dependent relaxation. Activation of the epidermal growth factor (EGF) receptor leads to transduction of signals from the plasma membrane for the release of
Publikováno v:
Clinical and Experimental Immunology. 173:390-397
Summary Autoantibodies to the thyrotrophin (TSH) receptor (anti-TSHR) are unique, in that they are involved directly in the pathophysiology of certain autoimmune thyroid diseases (AITD). Thyroid-stimulating antibodies (TSAb) act as agonists that acti
Publikováno v:
Journal of Radiation Research
We examined the radioprotective and mitigative effects of gamma-tocopherol-N,N-dimethylglycine ester (GTDMG), a novel water-soluble gamma-tocopherol derivative, against X-irradiation-induced bone marrow death in mice. Mice (C3H, 10 weeks, male) were
Publikováno v:
Sleep. 36:1227-1238
Study objective Systemic tumor necrosis factor-α (TNF-α) is linked to sleep and sleep altering pathologies in humans. Evidence from animals indicates that systemic and brain TNF-α have a role in regulating sleep. In animals, TNF-α or lipopolysacc
Autor:
Xiaoming Zhang, Shoulin Wang, Xuhui Zhang, Yudong Zhang, Xinru Wang, Minjian Chen, Zhan Zhang, Jun Gu, Liang-Lin Qiu
Publikováno v:
Toxicological Sciences. 135:229-240
Perfluorooctane sulfonate (PFOS) is associated with male reproductive disorders, but its targets and mechanisms are poorly understood. We used in vitro and in vivo models to explore the roles of Sertoli cells and the blood-testis barrier (BTB) in PFO
Autor:
R. Clinton Webb, Haroldo A. Toque, Kenia Pedrosa Nunes, R. William Caldwell, Lin Yao, James K. Liao, Ruth B. Caldwell
Publikováno v:
The Journal of Sexual Medicine. 10:1502-1515
Introduction Activated RhoA/Rho kinase (ROCK) has been implicated in diabetes‐induced erectile dysfunction. Earlier studies have demonstrated involvement of ROCK pathway in the activation of arginase in endothelial cells. However, signaling pathway