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Publikováno v:
Journal of Pharmacy and Pharmacology. 72:227-235
Objectives We aimed to investigate the effects of icariside II (ICS II) on myocardial fibrosis in spontaneously hypertensive rats (SHRs) and to explore the possible mechanisms. Methods We used SHRs as animal models, and we administered ICS II (4, 8 o
Publikováno v:
Journal of Pharmacy and Pharmacology. 71:996-1006
Objectives This study is designed to evaluate the role of tuberoinfundibular peptide of 39 (TIP39) in connection with glucocorticoid receptor-mediated glutamate/GABA abnormalities in chronic unpredictable mild stress (CUMS) model. Methods Male Spragu
Autor:
Dany Plourde, Kiran Makhani, Maryse Lemaire, Catherine A. Lemarié, Christopher Chiavatti, Stephanie Lehoux, Luis Fernando Negro Silva, Koren K. Mann
Publikováno v:
Toxicological Sciences. 166:213-218
Arsenic exposure increases the risk of atherosclerosis, the gradual occlusion of the large arteries with fibro-fatty plaque. While epidemiologic data provide convincing evidence this is true at higher exposures, it is unclear whether this may occur a
Publikováno v:
International Journal of Neuropsychopharmacology
Background Prostaglandin (PG) D2 is the most abundant prostaglandin in the mammalian brain. The physiological and pharmacological actions of PGD2 in the central nervous system seem to be associated with some of the symptoms exhibited by patients with
Autor:
Lijuan Tong, Yibin Qin, Jili Wang, Peng Wang, Wei Zhang, Rongrong Yang, Wenfeng Hu, Fengguo Liu, Yu Gong, Zhuo Chen, Chao Huang, Bo Jiang
Publikováno v:
International Journal of Neuropsychopharmacology
Background: Z-guggulsterone, an active compound extracted from the gum resin of the tree Commiphora mukul, has been shown to improve animal memory deficits via activating the brain-derived neurotrophic factor signaling pathway. Here, we investigated
Autor:
Matthias Majetschak, Richard H. Kennedy, Richard L. Gamelli, P. Geoff Vana, Ann E. Evans, Heather M. LaPorte
Publikováno v:
Journal of Burn Care & Research. 38:90-98
The effects of burn injury on cardiovascular responsiveness to vasoactive agents are not well understood. The aims of this study were to determine whether burn injury alters cardiovascular reactivity to vasoactive drugs in vivo and intrinsic function
Autor:
Christian Ellermann, Gerrit Frommeyer, Florian Reinke, Catharina Clauss, Christian Pott, Simon Kochhäuser, Harilaos Bogossian, Dirk G. Dechering, Lars Eckardt
Publikováno v:
EP Europace. 19:866-873
Aims The antiarrhythmic drug vernakalant exerts antiarrhythmic effects in atrial fibrillation. Recent experimental data suggest interactions with the late sodium current and antiarrhythmic effects in ventricular arrhythmias. We aimed at investigating
Autor:
Camilla F Wenceslau, Babak Baban, R. Clinton Webb, Takayuki Matsumoto, Cameron G. McCarthy, Styliani Goulopoulou
Publikováno v:
American Journal of Hypertension. 30:173-181
Background Innate immune system responses to damage-associated molecular patterns (DAMPs) are involved in hypertension. However, the mechanisms of this contribution are not well understood. Circulating mitochondrial DNA is a DAMP that activates Toll-
Autor:
Chengyin Yu, Liang Hu, Hui-hui Li, Cong Xi, Fei Gao, Sheng Yao, Yiping Wang, Yu-zhou Gui, Hong Yan, Ye Yang
Publikováno v:
Cardiovascular Research. 112:502-514
Aims Atherosclerosis is the most common cause of cardiovascular diseases, such as myocardial infarction and stroke. We hypothesized that nagilactone B (NLB), a small molecule extracted from the root bark of Podocarpus nagi (Podocarpaceae), suppresses
Autor:
Ioana Alesutan, Stefan Pilz, Martina Feger, Makoto Kuro-o, Kurt Schmidt, Tatsiana Castor, Burkert Pieske, Florian Lang, Andreas Tomaschitz, Katharina Musculus, Jakob Voelkl, Winfried Maerz, Rashad Tuffaha, Andreas Meinitzer, Salvatore S. Buehling, Christian L. Heine
Publikováno v:
Cardiovascular Research. 110:408-418
Aims Reduced homoarginine plasma levels are associated with unfavourable cardiovascular outcome in chronic kidney disease (CKD). Cardiovascular events in CKD are fostered by vascular calcification, an active process promoted by hyperphosphatemia and