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Autor:
Leon Earl Gray, Nicola Evans, Christy S. Lambright, Bethany R. Hannas, Justin M. Conley, Johnathan Furr, Hunter Sampson, Vickie S. Wilson, Paul M. D. Foster
Publikováno v:
Toxicol Sci
Previously, we demonstrated that exposure to some diortho-phthalate esters during sexual differentiation disrupts male reproductive development by reducing fetal rat testis testosterone production (T Prod) and gene expression in a dose-related manner
Autor:
Anushri Somavarapu, Glory Florence Meejuru, Lakshmi Sudeepthi Nissankara Roa, Ravi Chandra Sekhara Reddy Danduga, Phani Kumar Kola
Publikováno v:
Journal of Pharmacy and Pharmacology. 73:522-534
Objectives This study aimed to evaluate the effect of duloxetine (10 and 20 mg/kg) against chronic immobilisation stress (CIS)-induced anxiety, depression, cognitive impairment and neurodegeneration in mice. Methods CIS, 2 h/10 days (11:00 AM–1:00
Autor:
Lereko Kometsi, Edith Pascale Mofo Mato, Khmera Govender, Peter M. O. Owira, Rajendraparsad Hurchund
Publikováno v:
Journal of Pharmacy and Pharmacology. 72:1394-1404
Objectives Antioxidant and anti-inflammatory properties of naringenin could confer hepatoprotective effects. Methods Chang cells in culture media were maintained at 37°C and treated with increased concentrations of glucose (5.5–50 mm) and/or narin
Publikováno v:
Biology of Reproduction
Biology of Reproduction, Society for the Study of Reproduction, 2020, 102 (6), pp.1290-1305. ⟨10.1093/biolre/ioaa027⟩
Biology of Reproduction, Society for the Study of Reproduction, 2020, 102 (6), pp.1290-1305. ⟨10.1093/biolre/ioaa027⟩
Vaspin, visceral-adipose-tissue-derived serine protease inhibitor, is involved in the development of obesity, insulin resistance, inflammation, and energy metabolism. Our previous study showed vaspin expression and its regulation in the ovary; howeve
Publikováno v:
Journal of Pharmacy and Pharmacology. 72:227-235
Objectives We aimed to investigate the effects of icariside II (ICS II) on myocardial fibrosis in spontaneously hypertensive rats (SHRs) and to explore the possible mechanisms. Methods We used SHRs as animal models, and we administered ICS II (4, 8 o
Autor:
Anna Kakehashi, Hideki Wanibuchi, Takashi Yamaguchi, Michiharu Matsumoto, Masaki Fujioka, Yukari Totsuka, Min Gi, Shoji Fukushima, Kenichi Masumura
Publikováno v:
Mutagenesis. 34:279-287
Quantitative analysis of the mutagenicity and carcinogenicity of the low doses of genotoxic carcinogens present in food is of pressing concern. The purpose of the present study was to determine the mutagenicity and carcinogenicity of low doses of the
Publikováno v:
Journal of Pharmacy and Pharmacology. 71:220-229
Objectives The objective of this paper was to explore the effects of Radix isatidis polysaccharide (RIP) extracted from Radix isatis on alleviating insulin resistance. Methods The insulin resistance models of 3T3-L1 preadipocytes and type 2 diabetic
Autor:
Dany Plourde, Kiran Makhani, Maryse Lemaire, Catherine A. Lemarié, Christopher Chiavatti, Stephanie Lehoux, Luis Fernando Negro Silva, Koren K. Mann
Publikováno v:
Toxicological Sciences. 166:213-218
Arsenic exposure increases the risk of atherosclerosis, the gradual occlusion of the large arteries with fibro-fatty plaque. While epidemiologic data provide convincing evidence this is true at higher exposures, it is unclear whether this may occur a
Autor:
Qizhong Qin, Qianghu Tang, Shuqun Cheng, Lina Zhang, Zhen Zou, Yinyin Xia, Xuejun Jiang, Xuefeng Wang, Xia Qin, Bo Lv, Baijie Tu, Chengzhi Chen, Xianqing Cao, Pan Meng, Kai Yang, Lulu Bai, Shaoyu Mu
Publikováno v:
Toxicological Sciences. 165:431-446
Arsenite exposure is known to increase the risk of neurological disorders via alteration of dopamine content, but the detailed molecular mechanisms remain largely unknown. In this study, using both dopaminergic neurons of the PC-12 cell line and C57B
Autor:
Andrew B. Hawkey, Kathryn-Ann Odamah, Lilah Glazer, Edward D. Levin, Meghan Drastal, Corinne Wells, Mamta Behl
Publikováno v:
Toxicological Sciences. 165:487-498
As the older class of brominated flame retardants (BFRs) are phased out of commercial use because of findings of neurotoxicity with developmental exposure, a newer class of flame retardants have been introduced, the organophosphate flame retardants (