Zobrazeno 101 - 110
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Autor:
Bernd Hewing, Karl Stangl, Verena Stangl, Andrea Weller, Jana Grune, Carmen Hannemann, Edward A. Fisher, Antje Ludwig, Alica Brettschneider, Nicole Rösener, Johannes H Schecker
Publikováno v:
Cardiovasc Res
Aims Atherosclerosis is a chronic inflammatory disease of the arterial vessel wall and anti-inflammatory treatment strategies are currently pursued to lower cardiovascular disease burden. Modulation of recently discovered inactive rhomboid protein 2
Autor:
Jason Farthing, Stephen Hawley, Cameron R. Wolfe, Roy F. Chemaly, Jimmy Hwang, Stanley Lewis, George Wang, Steven J. Lawrence, Michael Boeckh, Paul Montanez, Jennifer Ho, Rosemary Soave, Sanjeet Dadwal, Francisco M. Marty
Publikováno v:
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Background There are no antiviral therapies for parainfluenza virus (PIV) infections. DAS181, a sialidase fusion protein, has demonstrated activity in in vitro and in animal models of PIV. Methods Adult immunocompromised patients diagnosed with PIV l
Publikováno v:
Pain Medicine. 22:2767-2779
Autor:
Juan Tamargo, Marcos Rubio-Alarcón, María Dago, Juan A. Bernal, Jorge Cebrián, Ricardo Caballero, Raquel G. Utrilla, Andrés González-Guerra, David Tinaquero, Paloma Nieto-Marín, José Jalife, Anabel Cámara-Checa, Jose Lopez-Sendon, Teresa Crespo-García, Rafael Peinado, David Filgueiras, Eva Delpón, Silvia Alfayate
Publikováno v:
Cardiovascular Research. 118:1046-1060
Aims The transcription factor Tbx5 controls cardiogenesis and drives Scn5a expression in mice. We have identified two variants in TBX5 encoding p. D111Y and p. F206L Tbx5, respectively, in two unrelated patients with structurally normal hearts diagno
Autor:
Peggy Berlin, Karen Bannert, Clemens Schafmayer, Christian Maschmeier, Maria Witte, Georg Lamprecht, Johannes Reiner, Robert Jaster
Publikováno v:
Inflammatory Bowel Diseases
Background Nucleotide-binding oligomerization domain-containing protein 2 (NOD2) mutations are a genetic risk factor for Crohn disease. Ileocecal resection is the most often performed surgery in Crohn disease. We investigated the effect of Nod2 knock
Autor:
Anushri Somavarapu, Glory Florence Meejuru, Lakshmi Sudeepthi Nissankara Roa, Ravi Chandra Sekhara Reddy Danduga, Phani Kumar Kola
Publikováno v:
Journal of Pharmacy and Pharmacology. 73:522-534
Objectives This study aimed to evaluate the effect of duloxetine (10 and 20 mg/kg) against chronic immobilisation stress (CIS)-induced anxiety, depression, cognitive impairment and neurodegeneration in mice. Methods CIS, 2 h/10 days (11:00 AM–1:00
Publikováno v:
J Infect Dis
Antiretroviral therapy effectively controls human immunodeficiency virus (HIV) replication but it is unable to fully eradicate the HIV reservoir and treatment must be life-long. Progress toward a strategy for HIV remission will require overcoming key
Autor:
Dobromir Dobrev, Na Li, Jilu Lang, Xiaolei Wang, Prashanthan Sanders, Larry D. Scott, George E. Taffet, Anke C. Fender, Darragh Twomey, Rodrigo Diaz-Lankenau, Markus Kamler, Mathias Hohl, Thuy T. Pham, Dominik Linz, Xiaohui Chen, Arnela Saljic, Mark L. Entman, Mihail G. Chelu, Luge Li
Publikováno v:
Cardiovascular Research, 117(7), 1746-1759. Oxford University Press
Cardiovasc Res
Cardiovasc Res
Aims Obesity, an established risk factor of atrial fibrillation (AF), is frequently associated with enhanced inflammatory response. However, whether inflammatory signaling is causally linked to AF pathogenesis in obesity remains elusive. We recently
Autor:
Stoyan Kondov, Martin Czerny, Matthias Siepe, Paul Puiu, Friedhelm Beyersdorf, Tim Walter, Julia Morlock, Tim Berger, Maximilian Kreibich, Clarence Pingpoh, Bartosz Rylski
Publikováno v:
European Journal of Cardio-Thoracic Surgery. 60:155-161
OBJECTIVES Our aim was to evaluate the mid-term outcomes of bovine pericardial tube graft repair for infectious aortic disease in any aortic segment. METHODS Between May 2015 and July 2020, 45 patients were treated for infectious aortic disease of th
Publikováno v:
Journal of Applied Microbiology. 130:314-324
Aims To develop an oral delivery system of glucagon-like peptide 1 (GLP-1) (28–36) for treating type-2 diabetes, B.S-GLP-1(28–36), a recombinant Bacillus subtilis spores transformed with a plasmid vector encoding five consecutive GLP-1 (28–36)