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Autor:
Teresa R Gray, Crystal Arndt
Publikováno v:
Journal of Analytical Toxicology. 46:e73-e77
Phenibut, a GABAB agonist structurally similar to baclofen, is not approved for medical use in the USA but is available through internet suppliers for recreational use. Calls to poison control centers for phenibut have increased over the last 5 years
Publikováno v:
Journal of AOAC INTERNATIONAL. 105:19-25
Background Validated ultra-performance liquid chromatography (UPLC) and thin-layer chromatography (TLC) densitometric methods were prescribed for determination of antihypertensive components. Objective To establish and validate rapid and accurate UPL
Publikováno v:
Journal of AOAC INTERNATIONAL. 104:1667-1680
Background Drug counterfeiting is a rising problem due to difficulties with identifying counterfeit drugs and the lack of regulations and legislation in developing countries. Objective This study aims to develop a robust and economic reversed phase h
Publikováno v:
Journal of AOAC INTERNATIONAL. 104:1453-1463
Background Concomitant montelukast and bilastine are used as additive therapy for seasonal allergic rhinoconjuctivitis and mild to moderate asthma. According to a literature review, no UV-visible spectrophotometric method has been reported yet for si
Publikováno v:
Journal of Analytical Toxicology. 45:780-791
Buprenorphine (BUP) is a commonly prescribed medication for the treatment of opioid use disorder (OUD). As prescriptions increase in North Carolina, BUP is more frequently encountered statewide in routine postmortem casework. Between 2010 and 2018, t
Autor:
Waleed H. Almalki, Rehan Abdur Rub, Kriti Soni, Majed Alrobaian, Fahad A. Al-Abbasi, Mahfoozur Rahman, Naushad Alam, Imran Kazmi, Manal A Alossaimi, Ozair Alam, Obaid Afzal, Sagar Suman Panda, Sarwar Beg
Publikováno v:
Journal of Chromatographic Science. 60:551-558
Neratinib, a tyrosine kinase inhibitor, was very recently approved by USFDA in 2017 as an anticancer drug to treat of HER2 positive breast cancers. The present work provides an account on the development of a validated bioanalytical UPLC–MS/MS meth
Publikováno v:
Journal of Chromatographic Science. 59:785-794
A simple, accurate, rapid and sensitive reversed-phase high-performance liquid chromatography (RP-HPLC) method was established for determination of a novel non-vitamin K antagonist oral anticoagulant drug, betrixaban, and its co-administered calcium-
Publikováno v:
Journal of Analytical Toxicology. 46:658-669
Driving under the influence of drug (DUID) cases continue to challenge forensic toxicologists as both the volume and complexity of casework increases. Comprehensive DUID testing should also meet the drafted Academy Standards Board (ASB)/ American Nat
Autor:
Aline Correa Ribeiro, Jorge Willian Leandro Nascimento, Carlos Alberto Mourão-Júnior, Luciane Henriques Furtado Barroso, Julio Maria Fonseca Chebli
Publikováno v:
Journal of Chromatographic Science. 60:518-524
The conversion of azathioprine (AZA) to active 6-thioguanine nucleotides (6-TGN) is essential for its clinical efficacy; however, another metabolite formed, 6-methylmercaptopurine (6-MMP), is related to hepatotoxicity. Blood samples were collected fr
Publikováno v:
Journal of Analytical Toxicology. 46:625-632
Smokeless tobacco (ST) products are used worldwide, and consumption is increasing in the USA. Although ST products are considered to occupy a different position on the tobacco product continuum of risk compared to combusted tobacco products, they can