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Autor:
John W. Prineas, John Parratt
Publikováno v:
Journal of Neuropathology and Experimental Neurology
This study examined the roles of microglia and monocytes in myelin destruction in patients with early multiple sclerosis (MS). Twenty-two cases were studied; the clinical duration was
Publikováno v:
American Journal of Clinical Pathology. 156:871-885
Objectives Follicular hyperplasias (FHs) with light chain–restricted (LCR) plasmacytoid/plasma cells (PCs) within germinal centers (GCs) based on immunohistochemistry (IHC)/in situ hybridization (ISH) can potentially lead to diagnostic error. This
Publikováno v:
J Neuropathol Exp Neurol
Alzheimer disease (AD) is a progressive neurodegenerative disease causing cognitive decline in the aging population. To develop disease-modifying treatments, understanding the mechanisms behind the pathology is important, which should include observa
Autor:
Katsushi Igarashi, Masanori Fujimoto, Hisashi Koide, Tomohiko Ichikawa, Kumiko Naito, Yutarou Ruike, Shinichi Sakamoto, Sawako Suzuki, Yusuke Imamura, Jun-ichiro Ikeda, Akiko Ishida, Kazuki Ishiwata, Hanna Deguchi-Horiuchi, Koutaro Yokote
Publikováno v:
European Journal of Endocrinology. 185:155-165
Introduction Although 18F-FDG PET was originally developed to evaluate benign and malignant tumors, the frequency of detection of benign adrenocortical adenomas showing FDG-PET accumulation has increased. However, the details of FDG-PET-accumulated b
Autor:
Badrinath R Konety, Joost L. Boormans, Vikram M. Narayan, Ewan A. Gibb, Joep J. de Jong, Geert J.L.H. van Leenders, Shilpa Gupta, Andrea Cronican
Publikováno v:
American Journal of Clinical Pathology, 156(5), 895-905. Oxford University Press
Objectives To determine the potential impact of the presence of secondary variant histology on the gene expression profiles of muscle-invasive bladder cancer (MIBC) tumors. Methods For six tumors, revised samples were collected from urothelial and se
Autor:
Xu Zhang, Chun-Sheng Yang, Lin-Jie Zhang, Jing Wang, Qiu-Xia Zhang, Kun Jia, Li Yang, Ning Zhao, Hui Zhai, Ming Yi, Sheng-Hui Chang, Xiao-Wen Li
Publikováno v:
Clin Exp Immunol
Summary Anti-neurofascin-155 (NF155) antibodies have been observed in two cases with neuromyelitis optica spectrum disorders (NMOSD). This study investigated the prevalence of anti-NF155 antibodies in patients with NMOSD and the clinical features of
Publikováno v:
American Journal of Clinical Pathology. 156:913-919
Objectives Pathologic evaluation of nonneoplastic renal parenchyma in nephrectomy specimens is important for identifying chronic kidney disease and diabetic nephropathy, but increasing utilization of partial nephrectomies has led to less-sampled nonn
Autor:
Tammaryn Lashley, Kerstin Sander, Nick C. Fox, Steven Y Yap, Michael Schöll, Barbara Frias, Erik Årstad, Melissa C. Wren
Publikováno v:
Brain
A next generation of tau PET tracers for the imaging of Alzheimer’s disease and other dementias has recently been developed. Whilst the new compounds have now entered clinical studies, there is limited information available to assess their suitabil
Autor:
Xiao Xiao, Hongqi Zhang, Gao Zeng, Xinru Xiao, Jie Tang, Guilin Li, Jian Ren, Yuru Zong, Wei Yukui, Yibo Wang, Nan Jiang, Jiantao Liang, Shan Yongzhi, Peng Hu, Ming Ye, Zqi Kou, Jian Zou, Hao Wu, Bing Cui, Guolu Meng, Liyong Sun, Zan Chen, Tao Hong, Rutai Hui
Publikováno v:
Brain. 144:2648-2658
Cavernous malformations affecting the CNS occur in ∼0.16–0.4% of the general population. The majority (85%) of cavernous malformations are in a sporadic form, but the genetic background of sporadic cavernous malformations remains enigmatic. Of th
Autor:
Kazuo Fujihara, Tatsuro Misu, Yoshiki Takai, Masashi Aoki, Shuhei Nishiyama, Hans Lassmann, Y. Matsumoto, Yasuto Itoyama, Ichiro Nakashima, Mika Watanabe, Hiroyoshi Suzuki, Shinya Tanaka, Hirohiko Ono, Toshiyuki Takahashi, Kenji Okita, Chihiro Namatame, Hiroshi Kuroda, Shunichi Sasou, Hiromi Okada, Kimihiko Kaneko
Publikováno v:
Brain. 144:2401-2415
Aquaporin 4 (AQP4)-IgG-positive neuromyelitis optica spectrum disorder (AQP4-IgG+NMOSD) is an autoimmune astrocytopathic disease pathologically characterized by the massive destruction and regeneration of astrocytes with diverse types of tissue injur