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While novel technologies such as high-throughput screening have advanced together with significant investment by pharmaceutical companies during the past decades, the success rate for drug development has not yet been improved prompting researchers l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b20b2a7041a66c8e42633897084b981
https://europepmc.org/articles/PMC6781586/
https://europepmc.org/articles/PMC6781586/
Publikováno v:
Nucleic Acids Research
PubChem (http://pubchem.ncbi.nlm.nih.gov) is a public repository for information on chemical substances and their biological activities, developed and maintained by the US National Institutes of Health (NIH). PubChem contains more than 180 million de
Autor:
Renata C. Geer, Aron Marchler-Bauer, Paul A. Thiessen, Christopher J. Lanczycki, Stephen H. Bryant, Dachuan Zhang, Thomas Madej
Publikováno v:
Nucleic Acids Research
The computational detection of similarities between protein 3D structures has become an indispensable tool for the detection of homologous relationships, the classification of protein families and functional inference. Consequently, numerous algorith
Autor:
David I. Hurwitz, Christopher J. Lanczycki, Noreen R. Gonzales, Stephen H. Bryant, Farideh Chitsaz, James S. Song, Marc Gwadz, Gabriele H. Marchler, Narmada Thanki, Lewis Y. Geer, Dachuan Zhang, Renata C. Geer, Fu Lu, Chanjuan Zheng, Roxanne A. Yamashita, Myra K. Derbyshire, Aron Marchler-Bauer, Shennan Lu
Publikováno v:
Nucleic Acids Research
CDD, the Conserved Domain Database, is part of NCBI’s Entrez query and retrieval system and is also accessible via http://www.ncbi.nlm.nih.gov/Structure/cdd/cdd.shtml. CDD provides annotation of protein sequences with the location of conserved doma
Autor:
Chunlei Liu, Renata C. Geer, Kenneth J. Addess, Anna R. Panchenko, Lewis Y. Geer, Thomas Madej, Stephen H. Bryant, Aron Marchler-Bauer, Christopher J. Lanczycki, Shennan Lu, Jie Chen, Jessica H. Fong, Dachuan Zhang, Yanli Wang, Paul A. Thiessen
Publikováno v:
Nucleic Acids Research
Close to 60% of protein sequences tracked in comprehensive databases can be mapped to a known three-dimensional (3D) structure by standard sequence similarity searches. Potentially, a great deal can be learned about proteins or protein families of in
Autor:
Fu-Ping Lu, Carol DeWeese-Scott, John B. Anderson, James S. Song, Christopher J. Lanczycki, Zhaoxi Ke, Farideh Chitsaz, John D. Jackson, Mikhail Mullokandov, Roxanne A. Yamashita, Aron Marchler-Bauer, Marina V. Omelchenko, Chanjuan Zheng, Naigong Zhang, Noreen R. Gonzales, Marc Gwadz, Cynthia L. Robertson, Stephen H. Bryant, Gabriele H. Marchler, Jessica H. Fong, David I. Hurwitz, Lewis Y. Geer, Narmada Thanki, Renata C. Geer, Dachuan Zhang, Myra K. Derbyshire, Shennan Lu
Publikováno v:
Nucleic Acids Research
NCBI's Conserved Domain Database (CDD) is a resource for the annotation of protein sequences with the location of conserved domain footprints, and functional sites inferred from these footprints. CDD includes manually curated domain models that make
Publikováno v:
Nucleic Acids Research
The sequencing of complete genomes has created a pressing need for automated annotation of gene function. Because domains are the basic units of protein function and evolution, a gene can be annotated from a domain database by aligning domains to the
Autor:
Anna R. Panchenko, Saikat Chakrabarti, Christopher J. Lanczycki, Teresa M. Przytycka, Stephen H. Bryant, Paul A. Thiessen
Publikováno v:
Nucleic Acids Research
Accurate multiple sequence alignments of proteins are very important to several areas of computational biology and provide an understanding of phylogenetic history of domain families, their identification and classification. This article presents a n
Autor:
Cynthia A. Liebert, David I. Hurwitz, Stephen H. Bryant, Gabriele H. Marchler, Paul A. Thiessen, Vahan Simonyan, James S. Song, Dachuan Zhang, Jodie J. Yin, John B. Anderson, Benjamin A. Shoemaker, John D. Jackson, Lewis Y. Geer, Carol DeWeese-Scott, Mikhail Mullokandov, Siqian He, Roxanne A. Yamashita, Christopher J. Lanczycki, Zhaoxi Ke, Chunlei Liu, Fu Lu, Aron Marchler-Bauer, Marc Gwadz, Praveen F. Cherukuri
Publikováno v:
Nucleic Acids Research
The Conserved Domain Database (CDD) is the protein classification component of NCBI's Entrez query and retrieval system. CDD is linked to other Entrez databases such as Proteins, Taxonomy and PubMed®, and can be accessed at http://www.ncbi.nlm.nih.g
Publikováno v:
Database: The Journal of Biological Databases and Curation
New generation sequencing technologies have resulted in significant increases in the number of complete genomes. Functional characterization of these genomes, such as by high-throughput proteomics, is an important but challenging task due to the diff