Zobrazeno 1 - 10
of 336
pro vyhledávání: '"RNA Interference"'
RNAi and Ino80 complex control rate limiting translocation step that moves rDNA to eroding telomeres
Publikováno v:
Nucleic Acids Research
The discovery of HAATIrDNA, a mode of telomerase-negative survival in which canonical telomeres are replaced with ribosomal DNA (rDNA) repeats that acquire chromosome end-protection capability, raised crucial questions as to how rDNA tracts ‘jump
Publikováno v:
Nucleic Acids Research
Metal-induced genes are usually transcribed at relatively low levels under normal conditions and are rapidly activated by heavy metal stress. Many of these genes respond preferentially to specific metal-stressed conditions. However, the mechanism by
Autor:
Ayako Wada-Katsumata, Akihiko Yamamoto, Wen Huang, Aya Yanagawa, Coby Schal, Trudy F. C. Mackay
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 10, Iss 9, Pp 3453-3460 (2020)
Spontaneous grooming behavior is a component of insect fitness. We quantified spontaneous grooming behavior in 201 sequenced lines of the Drosophila melanogaster Genetic Reference Panel and observed significant genetic variation in spontaneous groomi
Autor:
Xiangyang Chen, Shimiao Liao, Chengming Zhu, Ting Xu, Zongxiu Xu, Demin Xu, Xufei Zhou, Qile Jin, Shouhong Guang, Xuezhu Feng
Publikováno v:
Nucleic Acids Research
Eukaryotic cells express a wide variety of endogenous small regulatory RNAs that function in the nucleus. We previously found that erroneous rRNAs induce the generation of antisense ribosomal siRNAs (risiRNAs) which silence the expression of rRNAs vi
Autor:
Kazumasa Minami, Rika Kondo, Yuji Seo, Yutaka Takahashi, Keisuke Tamari, Hirofumi Yamamoto, Kazuhiko Ogawa, Fumiaki Isohashi, Takanori Adachi, Yuhki Yokoyama, Wantong Zhao, Daisuke Okuzaki, Masahiko Koizumi
Publikováno v:
Journal of Radiation Research
Radiation therapy is generally effective for treating breast cancers. However, approximately 30% of patients with breast cancer experience occasional post-treatment local and distant metastasis. Low-dose (0.5 Gy) irradiation is a risk factor that pro
Autor:
Yueying Zhang, Alberto Carbonell, Matthew Norris, Jiawei Wang, Jitender Cheema, Maria Louisa Vigh, Xiaofeng Fang, Yiliang Ding, Xiaofei Yang, Sha Yu, Peter Brodersen, Qi Liu, Hugh C. Woolfenden, Minglei Yang
Publikováno v:
Nucleic Acids Research
Digital.CSIC. Repositorio Institucional del CSIC
instname
Yang, M, Woolfenden, H C, Zhang, Y, Fang, X, Liu, Q, Vigh, M L, Cheema, J, Yang, X, Norris, M, Yu, S, Carbonell, A, Brodersen, P, Wang, J & Ding, Y 2020, ' Intact RNA structurome reveals mRNA structure-mediated regulation of miRNA cleavage in vivo ', Nucleic Acids Research, vol. 48, no. 15, pp. 8767-8781 . https://doi.org/10.1093/nar/gkaa577
RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
Digital.CSIC. Repositorio Institucional del CSIC
instname
Yang, M, Woolfenden, H C, Zhang, Y, Fang, X, Liu, Q, Vigh, M L, Cheema, J, Yang, X, Norris, M, Yu, S, Carbonell, A, Brodersen, P, Wang, J & Ding, Y 2020, ' Intact RNA structurome reveals mRNA structure-mediated regulation of miRNA cleavage in vivo ', Nucleic Acids Research, vol. 48, no. 15, pp. 8767-8781 . https://doi.org/10.1093/nar/gkaa577
RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
[EN] MicroRNA (miRNA)-mediated cleavage is involved in numerous essential cellular pathways. miRNAs recognize target RNAs via sequence complementarity. In addition to complementarity, in vitro and in silico studies have suggested that RNA structurema
Autor:
W. Richard McCombie, Christopher M. Hammell, Melissa Kramer, Natalia Stec, Jesse Gillis, Olivia Mendivil Ramos, Nuri Kim, Shane McCarthy, Cristina Aguirre-Chen
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 10, Iss 5, Pp 1617-1628 (2020)
Analysis of patient-derived DNA samples has identified hundreds of variants that are likely involved in neuropsychiatric diseases such as autism spectrum disorder (ASD) and schizophrenia (SCZ). While these studies couple behavioral phenotypes to indi
Publikováno v:
Nucleic Acids Research
Uridine insertion/deletion editing of mitochondrial mRNAs is a characteristic feature of kinetoplastids, including Trypanosoma brucei. Editing is directed by trans-acting gRNAs and catalyzed by related RNA Editing Core Complexes (RECCs). The non-cata
Autor:
Theodore M Hill, Ronald B. Emeson, Peter A. Beal, Vandana M Gaded, Turnee N Malik, Erin E Doherty
Publikováno v:
Nucleic Acids Research
Nucleic acids research, vol 49, iss 7
Nucleic acids research, vol 49, iss 7
The hydrolytic deamination of adenosine-to-inosine (A-to-I) by RNA editing is a widespread post-transcriptional modification catalyzed by the adenosine deaminase acting on RNA (ADAR) family of proteins. ADAR-mediated RNA editing modulates cellular pa
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 11, Pp 3825-3832 (2019)
G3: Genes|Genomes|Genetics
G3: Genes|Genomes|Genetics
RNA silencing pathways play critical roles in maintaining quiescence of transposons in germ cells to promote genome integrity. However the precise mechanism by which different types of transposons are recognized by these pathways is not fully underst