Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Gerstein, Hertzel C."'
Autor:
Nead, Kevin T., Li, Aihua, Wehner, Mackenzie R., Neupane, Binod, Gustafsson, Stefan, Butterworth, Adam, Engert, James C., Davis, A. Darlene, Hegele, Robert A., Miller, Ruby, den Hoed, Marcel, Khaw, Kay-Tee, Kilpeläinen, Tuomas O., Wareham, Nick, Edwards, Todd L., Hallmans, Göran, Varga, TiborV., Kardia, SharonL.R., Smith, Jennifer A., Zhao, Wei, Faul, Jessica D., Weir, David, Mi, Jie, Xi, Bo, Quinteros, Samuel Canizales, Cooper, Cyrus, Sayer, Avan Aihie, Jameson, Karen, Grøntved, Anders, Fornage, Myriam, Sidney, Stephen, Hanis, Craig L., Highland, Heather M., Häring, Hans-Ulrich, Heni, Martin, Lasky-Su, Jessica, Weiss, Scott T., Gerhard, Glenn S., Still, Christopher, Melka, Melkaey M., Pausova, Zdenka, Paus, Tomáš, Grant, Struan F.A., Hakonarson, Hakon, Price, R Arlen, Wang, Kai, Scherag, Andre, Hebebrand, Johannes, Hinney, Anke, BioBank Japan, AGEN-BMI, GIANT Consortium, Franks, Paul W., Frayling, Timothy M., McCarthy, Mark I., Hirschhorn, Joel N., Loos, Ruth, Ingelsson, Erik, Gerstein, Hertzel C., Yusuf, Salim, Beyene, Joseph, Anand, Sonia S., Meyre, David
Publikováno v:
Nead, K T, Li, A, Wehner, M R, Neupane, B, Gustafsson, S, Butterworth, A, Engert, J C, Davis, A D, Hegele, R A, Miller, R, den Hoed, M, Khaw, K-T, Kilpeläinen, T O, Wareham, N, Edwards, T L, Hallmans, G, Varga, T V, Kardia, S L R, Smith, J A, Zhao, W, Faul, J D, Weir, D, Mi, J, Xi, B, Quinteros, S C, Cooper, C, Sayer, A A, Jameson, K, Grøntved, A, Fornage, M, Sidney, S, Hanis, C L, Highland, H M, Häring, H-U, Heni, M, Lasky-Su, J, Weiss, S T, Gerhard, G S, Still, C, Melka, M M, Pausova, Z, Paus, T, Grant, S F A, Hakonarson, H, Price, R A, Wang, K, Scherag, A, Hebebrand, J, Hinney, A, Franks, P W & BioBank Japan, AGEN-BMI, GIANT Consortium 2015, ' Contribution of common non-synonymous variants in PCSK1 to body mass index variation and risk of obesity : a systematic review and meta-analysis with evidence from up to 331 175 individuals ', Human Molecular Genetics, vol. 24, no. 12, pp. 3582-3594 . https://doi.org/10.1093/hmg/ddv097
Hum. Mol. Genet. 24, 3582-3594 (2015)
Hum. Mol. Genet. 24, 3582-3594 (2015)
Polymorphisms rs6232 and rs6234/rs6235 in PCSK1 have been associated with extreme obesity [e.g. body mass index (BMI) ≥ 40 kg/m(2)], but their contribution to common obesity (BMI ≥ 30 kg/m(2)) and BMI variation in a multi-ethnic context is unclea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7715ade4529c88f071c39259d2b3a6e
https://europepmc.org/articles/PMC4498155/
https://europepmc.org/articles/PMC4498155/
Autor:
Mohammedi K; Population Health Research Institute, McMaster University, 237 Barton St. E, Hamilton, ON, Canada L8L 2X2.; INSERM, BMC, U1034, Université de Bordeaux, Avenue de Magellan, 33604 Pessac, France., Pigeyre M; Population Health Research Institute, McMaster University, 237 Barton St. E, Hamilton, ON, Canada L8L 2X2., Bosch J; Population Health Research Institute, McMaster University, 237 Barton St. E, Hamilton, ON, Canada L8L 2X2.; School of Rehabilitation Science, McMaster University, Hamilton, ON, Canada., Yusuf S; Population Health Research Institute, McMaster University, 237 Barton St. E, Hamilton, ON, Canada L8L 2X2., Gerstein HC; Population Health Research Institute, McMaster University, 237 Barton St. E, Hamilton, ON, Canada L8L 2X2.
Publikováno v:
European heart journal [Eur Heart J] 2024 May 21; Vol. 45 (19), pp. 1738-1749.
Autor:
Retnakaran R; Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, ON M5T 3L9, Canada.; Division of Endocrinology, University of Toronto, Toronto, ON M5S 3H2, Canada.; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada., Kashyap SR; Division of Endocrinology, Diabetes, and Metabolism, New York Presbyterian-Weill Cornell Medicine, New York, NY 10021, USA., Gerstein HC; Division of Endocrinology, McMaster University, Hamilton, ON L8S 4K1, Canada., Aroda VR; Division of Endocrinology, Diabetes & Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Publikováno v:
The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2024 Apr 19; Vol. 109 (5), pp. 1179-1188.
Autor:
Wang R; Center for Clinical Epidemiology and Methodology (CCEM), Guangdong Second Provincial General Hospital, Guangzhou, China., Gerstein HC; Department of Medicine, McMaster University, Hamilton, ON, Canada.; Population Health Research Institute, McMaster University, Hamilton, ONCanada., Van Spall HGC; Department of Medicine, McMaster University, Hamilton, ON, Canada.; Population Health Research Institute, McMaster University, Hamilton, ONCanada., Lip GYH; Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital, Liverpool, United Kingdom.; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark., Olier I; Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital, Liverpool, United Kingdom.; School of Computer Science and Mathematics, Liverpool John Moores University, Liverpool, United Kingdom., Ortega-Martorell S; Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital, Liverpool, United Kingdom.; School of Computer Science and Mathematics, Liverpool John Moores University, Liverpool, United Kingdom., Thabane L; Father Sean O'Sullivan Research Centre, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.; Department of Health Research Methods, Evidence, and Impact (HEI), McMaster University, Hamilton, ON, Canada., Ye Z; Department of Cardiology, Guangdong Second Provincial General Hospital, Guangzhou, China., Li G; Center for Clinical Epidemiology and Methodology (CCEM), Guangdong Second Provincial General Hospital, Guangzhou, China.; Father Sean O'Sullivan Research Centre, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.; Department of Health Research Methods, Evidence, and Impact (HEI), McMaster University, Hamilton, ON, Canada.
Publikováno v:
European heart journal. Quality of care & clinical outcomes [Eur Heart J Qual Care Clin Outcomes] 2023 Aug 07; Vol. 9 (5), pp. 547.
Autor:
Goldman A; Sackler Faculty of Medicine, Tel-Aviv University, Ramat Aviv, Tel Aviv 69978, Israel.; Leviev Heart Center, Sheba Medical Center, Derech Sheba 2, Ramat Gan, Israel.; Department of Internal Medicine, Sheba Medical Center, Derech Sheba 2, Ramat Gan, Israel., Raschi E; Pharmacology Unit, Department of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy., Cukierman-Yaffe T; Division of Endocrinology & Metabolism, Sheba Medical Center, Derech Sheba 2, Ramat Gan, Israel.; Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel., Dankner R; Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel.; Unit for Cardiovascular Epidemiology, The Gertner Institute for Epidemiology and Health Policy Research, Sheba Medical Center, Derech Sheba 2, Ramat Gan, Israel., Shouval R; Adult Bone Marrow Transplantation Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Shechter M; Sackler Faculty of Medicine, Tel-Aviv University, Ramat Aviv, Tel Aviv 69978, Israel.; Leviev Heart Center, Sheba Medical Center, Derech Sheba 2, Ramat Gan, Israel., Ben-Zvi I; Sackler Faculty of Medicine, Tel-Aviv University, Ramat Aviv, Tel Aviv 69978, Israel.; Department of Internal Medicine, Sheba Medical Center, Derech Sheba 2, Ramat Gan, Israel., Gerstein HC; Population Health Research Institute, McMaster University Medical Centre-Hamilton Health Sciences, Hamilton, ON, Canada., Maor E; Sackler Faculty of Medicine, Tel-Aviv University, Ramat Aviv, Tel Aviv 69978, Israel.; Leviev Heart Center, Sheba Medical Center, Derech Sheba 2, Ramat Gan, Israel.
Publikováno v:
European journal of preventive cardiology [Eur J Prev Cardiol] 2022 Jul 20; Vol. 29 (9), pp. 1334-1342.
Autor:
Cukierman-Yaffe T; Endocrinology Institute, Sheba Medical Center, Ramat-Gan, and Epidemiology Department, Sackler School of Medicine, Herceg Institute of Aging, Tel Aviv University, Tel Aviv, Israel., Gerstein HC; Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Canada., Basile J; Medical University of South Carolina, Ralph H. Johnson VA Medical Center, Charleston, SC, USA., Bethel MA; Eli Lilly and Company, Indianapolis, IN, USA., Cardona-Muñoz EG; CUCS-Universidad de Guadalajara, Mexico., Conget I; Endocrinology and Nutrition Dpt. Hospital Clinic i Universitari, Barcelona, Spain., Dagenais G; Quebec Heart and Lung Institute, Laval University, Quebec City, Canada., Franek E; Mossakowski Medical Research Centre, Polish Academy of Sciences and Central Clinical Hospital MSWiA, Warsaw, Poland., Hall S; Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Canada., Hancu N; Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania., Jansky P; University Hospital Motol, Prague., Lakshmanan M; Eli Lilly and Company, Indianapolis, IN, USA., Lanas F; Universidad de La Frontera, Temuco, Chile., Leiter LA; Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Canada., Lopez-Jaramillo P; Masira Research Institute, Medical School, Universidad de Santander UDES, Bucaramanga, Colombia., Pirags V; University of Latvia, Pauls Stradiņš Clinical University Hospital, Riga, Latvia., Pogosova N; National Medical Research Center of Cardiology, Moscow, Russia., Probstfield J; Department of Medicine, University of Washington, Seattle, WA,USA., Rao-Melacini P; Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Canada., Ramasundarahettige C; Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Canada., Raubenheimer PJ; Department of Medicine, University of Cape Town, Cape Town, South Africa., Riddle MC; Department of Medicine, Oregon Health & Science University Portland, OR, USA., Rydén L; Department of Medicine K2, Karolinska Institutet, Stockholm, Sweden., Shaw JE; Baker Heart and Diabetes Institute, Melbourne, Australia., Sheu WH; Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan., Temelkova-Kurktschiev T; Robert Koch Medical Center, Sofia, Bulgaria.
Publikováno v:
The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2022 Jul 14; Vol. 107 (8), pp. e3448-e3454.
Autor:
Peled A; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Department of Ophthalmology, Assaf-Harofeh Medical Center, Zerifin, Israel., Raz I; The Diabetes Unit, Department of Internal Medicine, Hadassah Hebrew University Hospital, Jerusalem, Israel., Zucker I; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Ministry of Health, Israel Center for Disease Control, Ramat Gan, Israel., Derazne E; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Megreli J; Hebrew University-Hadassah Braun School of Public Health and Community, Jerusalem, Israel.; Israel Defense Forces Medical Corps, Ramat Gan, Israel., Pinhas-Hamiel O; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Pediatric Endocrine and Diabetes Unit, Edmond and Lily Safra Children's Hospital, Chaim Sheba Medical Center at Tel Hashomer, Ramat Gan, Israel., Einan-Lifshitz A; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Department of Ophthalmology, Assaf-Harofeh Medical Center, Zerifin, Israel., Morad Y; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Department of Ophthalmology, Assaf-Harofeh Medical Center, Zerifin, Israel., Pras E; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Department of Ophthalmology, Assaf-Harofeh Medical Center, Zerifin, Israel., Lutski M; Ministry of Health, Israel Center for Disease Control, Ramat Gan, Israel., Cukierman-Yaffe T; Ministry of Health, Israel Center for Disease Control, Ramat Gan, Israel.; Institute of Endocrinology, Chaim Sheba Medical Center at Tel Hashomer, Ramat Gan, Israel., Mosenzon O; The Diabetes Unit, Department of Internal Medicine, Hadassah Hebrew University Hospital, Jerusalem, Israel., Tzur D; Israel Defense Forces Medical Corps, Ramat Gan, Israel.; Department of Military Medicine, Hebrew University, Jerusalem, Israel., Tirosh A; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Institute of Endocrinology, Chaim Sheba Medical Center at Tel Hashomer, Ramat Gan, Israel., Gerstein HC; Department of Medicine, McMaster University, Hamilton, Ontario, Canada., Afek A; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Central Management, Chaim Sheba Medical Center at Tel Hashomer, Ramat Gan, Israel., Twig G; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Israel Defense Forces Medical Corps, Ramat Gan, Israel.; Institute of Endocrinology, Chaim Sheba Medical Center at Tel Hashomer, Ramat Gan, Israel.; Department of Military Medicine, Hebrew University, Jerusalem, Israel.
Publikováno v:
The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2022 Jan 18; Vol. 107 (2), pp. e663-e671.
Autor:
Riddle MC; Division of Endocrinology, Diabetes, & Clinical Nutrition, Department of Medicine, Oregon Health & Science University, Portland, OR, USA., Cefalu WT; Division of Diabetes, Endocrinology and Metabolic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA., Evans PH; College of Medicine and Health, University of Exeter, Exeter, U.K., Gerstein HC; Population Health Research Institute and Department of Medicine, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada., Nauck MA; Diabetes Division, Katholisches Klinikum Bochum gGmbH, St. Josef-Hospital, Ruhr University Bochum, Bochum, Germany., Oh WK; Division of Hematology and Medical Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Rothberg AE; Department of Internal Medicine, Michigan Medicine, and Department of Nutritional Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA., le Roux CW; Diabetes Complications Research Centre, University College Dublin, Dublin, Ireland., Rubino F; Department of Diabetes, School of Life Course Sciences, King's College London, London, U.K., Schauer P; Pennington Biomedical Research Center, Baton Rouge, LA, USA., Taylor R; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, U.K., Twenefour D; Diabetes UK, London, U.K.
Publikováno v:
The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2022 Jan 01; Vol. 107 (1), pp. 1-9.
Autor:
Shapiro M; Department of Internal Medicine T, Tel Aviv Sourasky Medical Center, Tel Aviv 6492601, Israel.; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.; Israel Defense Forces Medical Corps, Ramat Gan 5510802, Israel., Arbel C; Israel Defense Forces Medical Corps, Ramat Gan 5510802, Israel.; Department of Military Medicine, Hebrew University of Jerusalem, Faculty of Medicine, Jerusalem 9112102, Israel., Zucker I; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.; The Israel Center for Disease Control, Ministry of Health, Ramat Gan 5262160, Israel., Balmor GR; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.; Shamir (Assaf-Harofeh) Medical Center, Zerifin 70300, Israel., Lutski M; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.; The Israel Center for Disease Control, Ministry of Health, Ramat Gan 5262160, Israel., Derazne E; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel., Beer Z; Israel Defense Forces Medical Corps, Ramat Gan 5510802, Israel.; Department of Military Medicine, Hebrew University of Jerusalem, Faculty of Medicine, Jerusalem 9112102, Israel., Pinhas-Hamiel O; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.; Department of Pediatric Endocrinology, Safra Children Hospital, Sheba Medical Center, Tel Hashomer, Ramat Gan 5266202, Israel., Mosenzon O; The Diabetes Unit, Department of Internal Medicine, Hadassah Hebrew University Hospital, Jerusalem 91120, Israel., Tzur D; Israel Defense Forces Medical Corps, Ramat Gan 5510802, Israel.; Department of Military Medicine, Hebrew University of Jerusalem, Faculty of Medicine, Jerusalem 9112102, Israel., Afek A; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.; Central Management, Sheba Medical Center, Tel Hashomer, Ramat Gan 5266202, Israel., Tirosh A; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.; Institute of Endocrinology, Sheba Medical Center, Tel Hashomer, Ramat Gan 5266202, Israel., Cukierman-Yaffe T; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.; Institute of Endocrinology, Sheba Medical Center, Tel Hashomer, Ramat Gan 5266202, Israel., Gerstein HC; Department of Medicine, McMaster University, Hamilton, Ontario L8S 4M1, Canada., Rosenberg V; Maccabitech Research Institute, Maccabi Healthcare Services, Tel Aviv 6801296, Israel., Chodick G; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.; Maccabitech Research Institute, Maccabi Healthcare Services, Tel Aviv 6801296, Israel., Raz I; The Diabetes Unit, Department of Internal Medicine, Hadassah Hebrew University Hospital, Jerusalem 91120, Israel., Twig G; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.; Israel Defense Forces Medical Corps, Ramat Gan 5510802, Israel.; Department of Military Medicine, Hebrew University of Jerusalem, Faculty of Medicine, Jerusalem 9112102, Israel.; Institute of Endocrinology, Sheba Medical Center, Tel Hashomer, Ramat Gan 5266202, Israel.
Publikováno v:
The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2021 Nov 19; Vol. 106 (12), pp. e5043-e5053.
Autor:
Bardugo A; Department of Military Medicine, Hebrew University, Jerusalem and the Israel Defense Forces Medical Corps, Ramat Gan, Israel., Derazne E; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Zucker I; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; The Israel Center for Disease Control, Ministry of Health, Ramat Gan, Israel., Bendor CD; Department of Military Medicine, Hebrew University, Jerusalem and the Israel Defense Forces Medical Corps, Ramat Gan, Israel., Puris G; Department of Military Medicine, Hebrew University, Jerusalem and the Israel Defense Forces Medical Corps, Ramat Gan, Israel., Lutski M; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; The Israel Center for Disease Control, Ministry of Health, Ramat Gan, Israel., Pinhas-Hamiel O; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Pediatric Endocrine and Diabetes Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel., Cukierman-Yaffe T; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Institute of Endocrinology, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel., Mosenzon O; The Diabetes Unit, Department of Internal Medicine, Hadassah Hebrew University Hospital, Jerusalem, Israel., Schechter M; Department of Military Medicine, Hebrew University, Jerusalem and the Israel Defense Forces Medical Corps, Ramat Gan, Israel.; The Diabetes Unit, Department of Internal Medicine, Hadassah Hebrew University Hospital, Jerusalem, Israel., Tzur D; Department of Military Medicine, Hebrew University, Jerusalem and the Israel Defense Forces Medical Corps, Ramat Gan, Israel., Afek A; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Central Management, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel., Tirosh A; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Institute of Endocrinology, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel., Gerstein HC; Department of Medicine, McMaster University Hamilton, Ontario, Canada., Raz I; The Diabetes Unit, Department of Internal Medicine, Hadassah Hebrew University Hospital, Jerusalem, Israel., Twig G; Department of Military Medicine, Hebrew University, Jerusalem and the Israel Defense Forces Medical Corps, Ramat Gan, Israel.; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Institute of Endocrinology, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel.
Publikováno v:
The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2021 Aug 18; Vol. 106 (9), pp. e3426-e3435.