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Autor:
Runchu Li, Yanan Zhang, Qiuyu Qin, Xiaosen Jiang, Tianming Lan, Zhihua Ou, Yong Bai, Guoji Guo, Lihua Luo, Yixin Zhu, Haoyu Wang, Mingyi Pu, Huan Liu, Yuejiao Li, Ashley Chang, Chengcheng Sun, Cong Tan, Wendi Wu, Dongsheng Chen, Yi Jia, Xin Jin, Jiacheng Zhu, Wandong Zhao, Yanan Wei, Peiwen Ding, Yuting Yuan, Zhiyuan Lv, Xiangning Ding
Publikováno v:
Nucleic Acids Research
Viral infectious diseases are a devastating and continuing threat to human and animal health. Receptor binding is the key step for viral entry into host cells. Therefore, recognizing viral receptors is fundamental for understanding the potential tiss
Publikováno v:
Nucleic Acids Research
A core imprint of metazoan life is that perturbations of cell cycle are offset by compensatory changes in successive cellular generations. This trait enhances robustness of multicellular growth and requires transmission of signaling cues within a cel
Publikováno v:
Nucleic Acids Research
Controlling proper RNA pool for nuclear export is important for accurate gene expression. ZFC3H1 is a key controller that not only facilitates nuclear exosomal degradation, but also retains its bound polyadenylated RNAs in the nucleus upon exosome in
Publikováno v:
Journal of Molecular Cell Biology
Tumor development is a process involving loss of the differentiation phenotype and acquisition of stem-like characteristics, which is driven by intracellular rewiring of signaling network. The measurement of network reprogramming and disorder would b
Autor:
Hongyang Jing, Tiankun Hui, Peng Chen, Shunqi Wang, Daojun Hong, Min Yan, Tian Zhou, Xia Dong, Suqi Zou, Ziyang Liu, Erkang Fei, Dongyan Ren, Xinsheng Lai
Publikováno v:
Human Molecular Genetics
Duchenne muscular dystrophy (DMD) is an X-linked neuromuscular disease characterized by progressive wasting of skeletal muscles. The neuromuscular junction (NMJ) is a synapse between motor neurons and skeletal muscle fibers, critical for the control
Autor:
Azat K. Garaev, Mikhail D. Magnitov, Sergey V. Ulianov, Natalia Ovsyannikova, Alexander S. Mishin, Igor I. Kireev, Omar L. Kantidze, Alexander V. Tyakht, Sergey V. Razin, Artem V. Luzhin, Alexey A. Gavrilov, Alexey S. Gavrikov, Arkadiy K. Golov, Artem K. Velichko
Publikováno v:
Nucleic Acids Research
Liquid–liquid phase separation (LLPS) contributes to the spatial and functional segregation of molecular processes within the cell nucleus. However, the role played by LLPS in chromatin folding in living cells remains unclear. Here, using stochasti
Autor:
Richard Burke, Manon S. Oud, Anne E O'Connor, Ozlem Okutman, Daniel M Aguirre, Brendan J Houston, Moira K O'Bryan, Stéphane Viville, Joris A. Veltman, D. Jo Merriner
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 10, Iss 12, Pp 4449-4457 (2020)
G3: Genes|Genomes|Genetics
G3, 10, 12, pp. 4449-4457
G3, 10, 4449-4457
G3: Genes|Genomes|Genetics
G3, 10, 12, pp. 4449-4457
G3, 10, 4449-4457
Contains fulltext : 229297.pdf (Publisher’s version ) (Open Access) Globozoospermia is a rare form of male infertility where men produce round-headed sperm that are incapable of fertilizing an oocyte naturally. In a previous study where we undertoo
Publikováno v:
Nucleic Acids Research
During the past decade, genome-wide association studies (GWAS) have identified many genetic variants with susceptibility to several thousands of complex diseases or traits. The genetic regulation of gene expression is highly tissue-specific and cell
Autor:
Daniel K. Miller, Joseph S Cooper, Emil F. Khisamutdinov, Morgan Brittany Johnson, Justin R. Halman, Ian Marriott, Kirill A. Afonin
Publikováno v:
Nucleic Acids Research
Nucleic acid nanoparticles (NANPs) have become powerful new platforms as therapeutic and diagnostic tools due to the innate biological ability of nucleic acids to identify target molecules or silence genes involved in disease pathways. However, the c
Autor:
Anastas Popratiloff, Thomas M. Maynard, Sally A. Moody, Zahra Motahari, Anthony-Samuel LaMantia
Publikováno v:
Human Molecular Genetics
We identified divergent modes of initial axon growth that prefigure disrupted differentiation of the trigeminal nerve (CN V), a cranial nerve essential for suckling, feeding and swallowing (S/F/S), a key innate behavior compromised in multiple geneti