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Autor:
Marion J.J. Gijbels, Judith C. Sluimer, Ulf Hedin, Christoph Kuppe, J. De Bruijn, Thomas L. Theelen, Javier Perales-Patón, Rafael Kramann, Peter Carmeliet, Barend Mees, Leon J. Schurgers, Chris P. M. Reutelingsperger, E. Biessen, Elke Marsch, Andrew H. Baker, Jasper A. F. Demandt, Han Jin, Julio Saez-Rodriguez, K. van Kuijk, Ljubica Perisic Matic
Publikováno v:
Cardiovascular Research, 118(5), 1232-1246
Cardiovascular Research, 118(5), 1232-1246. Oxford University Press
Cardiovascular Research, 118(5), 1232-1246. Oxford University Press
AIMS: Atherosclerotic plaque hypoxia is detrimental for macrophage function. Prolyl hydroxylases (PHDs) initiate cellular hypoxic responses, possibly influencing macrophage function in plaque hypoxia. Thus, we aimed to elucidate the role of myeloid P
Publikováno v:
Rheumatology (Oxford, England)
Rheumatology, 60(7), 3088-3098. Oxford University Press
Rheumatology, 60(7), 3088-3098. Oxford University Press
A histologic hallmark of primary SS (pSS) is lymphocytic infiltration of the salivary and lacrimal glands, in particular by CD4+ T and B cells. In the early stages of the disease, infiltrates are dominated by CD4+ T cells, while B cell accumulation o
Publikováno v:
Antibody Therapeutics
Background CD3-based bispecific T cell engagers (bsTCEs) are one of the most promising bispecific antibodies for effective cancer treatments. To elicit target-specific T cell-mediated cytotoxicity, these bsTCEs contain at least one binding unit direc
Autor:
Renze Heidstra, Renan Pardal
Publikováno v:
Journal of Experimental Botany
Journal of Experimental Botany, 72(19), 6727-6738
Journal of Experimental Botany 72 (2021) 19
Journal of Experimental Botany, 72(19), 6727-6738
Journal of Experimental Botany 72 (2021) 19
The presence of two meristematic cell populations in the root and shoot apex allows plants to grow indefinitely. Due to its simple and predictable tissue organization, the Arabidopsis root apical meristem remains an ideal model to study mechanisms su
Autor:
Mechelle A Miller, Kaaren K. Reichard, Mark R. Litzow, Phuong L. Nguyen, James D. Hoyer, Elise R. Venable, Kurt R Bessonen, Constance P Chen, Aref Al-Kali, David S. Viswanatha, Dong Chen, Simon D Althoff, Jennifer L. Oliveira, Kebede H. Begna, Mrinal M. Patnaik, Rong He, Dana J Roh
Publikováno v:
American Journal of Clinical Pathology
Objectives SF3B1 mutations are the most common mutations in myelodysplastic syndromes (MDS). The International Working Group for the Prognosis of MDS (IWG-PM) recently proposed SF3B1-mutant MDS (SF3B1-mut-MDS) as a distinct disease subtype. We evalua
Autor:
Jeroen J. A. van Kampen, Henrik Endeman, Rogier A.S. Hoek, Richard Molenkamp, Diederik Gommers, Lihui Guo, Thomas Langerak, Marion Koopmans, Johannes P. C. van den Akker, Eric C. M. van Gorp, Bart L. Haagmans, Georges M. G. M. Verjans, Matthijs P. Raadsen, Jan H. von der Thüsen, Werner J. D. Ouwendijk, Robert M. Verdijk
Publikováno v:
Journal of Infectious Diseases, 223(9), 1512-1521. Oxford University Press
The Journal of infectious diseases, 223(9):https://doi.org/10.1093/infdis/jiab050. Oxford University Press
The Journal of Infectious Diseases
The Journal of infectious diseases, 223(9):https://doi.org/10.1093/infdis/jiab050. Oxford University Press
The Journal of Infectious Diseases
Lower respiratory tract (LRT) disease induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can deteriorate to acute respiratory distress syndrome (ARDS). Because the release of neutrophil extracellular traps (NETs) is implicated in
Autor:
Henry Watson, SL Perry, Philip Quirke, Amanda D. Race, Paul M. Loadman, Giles J. Toogood, Gael Nana, Mark A. Hull, Suparna Mitra, Henry M. Wood, Caroline Young
Publikováno v:
The Journal of Nutrition
Background Oral administration of purified omega-3 (ω-3) PUFAs is associated with changes to the fecal microbiome. However, it is not known whether this effect is associated with increased PUFA concentrations in the gut. Objectives We investigated t
Autor:
Hongyang Jing, Tiankun Hui, Peng Chen, Shunqi Wang, Daojun Hong, Min Yan, Tian Zhou, Xia Dong, Suqi Zou, Ziyang Liu, Erkang Fei, Dongyan Ren, Xinsheng Lai
Publikováno v:
Human Molecular Genetics
Duchenne muscular dystrophy (DMD) is an X-linked neuromuscular disease characterized by progressive wasting of skeletal muscles. The neuromuscular junction (NMJ) is a synapse between motor neurons and skeletal muscle fibers, critical for the control
Autor:
Melany Rios-Morales, Guido J. E. J. Hooiveld, Mara P H van Trijp, Freddy J. Troost, Robert-Jan M. Brummer, Ad A.M. Masclee, Ellen Wilms, Ben J.M. Witteman
Publikováno v:
The American Journal of Clinical Nutrition
The American journal of clinical nutrition 114 (2021) 3
The American journal of clinical nutrition, 114(3), 843-861
The American journal of clinical nutrition 114 (2021) 3
The American journal of clinical nutrition, 114(3), 843-861
Intestinal catheters have been used for decades in human nutrition, physiology, pharmacokinetics, and gut microbiome research, facilitating the delivery of compounds directly into the intestinal lumen or the aspiration of intestinal fluids in human s
Autor:
Koji Yasutomo
Publikováno v:
International Immunology
Pulmonary fibrosis is caused by the interplay between genetic and environmental factors. Recent studies have revealed various genes associated with idiopathic pulmonary fibrosis, as well as the causative genes for familial pulmonary fibrosis. Althoug