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CD4 T cells mediate brain inflammation and neurodegeneration in a mouse model of Parkinson's disease
Autor:
Asta Jurkuvenaite, Nicole J Gallups, David G. Standaert, Aubrey M Schonhoff, Ashley S. Harms, Gregory P. Williams
Publikováno v:
Brain
α-Synuclein, a key pathological component of Parkinson's disease, has been implicated in the activation of the innate and adaptive immune system. This immune activation includes microgliosis, increased inflammatory cytokines, and the infiltration of
Publikováno v:
Brain
Asby, D, Boche, D, Allan, S, Love, S & Miners, J S 2021, ' Systemic infection exacerbates cerebrovascular dysfunction in Alzheimer's disease ', Brain, vol. 144, no. 6, pp. 1869-1883 . https://doi.org/10.1093/brain/awab094
Asby, D, Boche, D, Allan, S, Love, S & Miners, J S 2021, ' Systemic infection exacerbates cerebrovascular dysfunction in Alzheimer's disease ', Brain, vol. 144, no. 6, pp. 1869-1883 . https://doi.org/10.1093/brain/awab094
See Huuskonen et al. (doi:10.1093/brain/awab168) for a scientific commentary on this article. Systemic infection exacerbates Alzheimer’s disease. In this postmortem study, Asby et al. provide evidence that it does so by raising the levels of multip
Autor:
Daniel S Malawsky, Martin Sill, Bridget Sanford, Andrew M. Donson, Siddhartha Mitra, Sujatha Venkataraman, Seth J. Weir, Kent Riemondy, Nicholas Willard, Andrea Griesinger, Rajeev Vibhakar, Timothy R. Gershon, Todd C. Hankinson, Robert J. Wechsler-Reya, Jay R. Hesselberth, Alexandra Garancher, Anandani Nellan, Jennifer Ocasio, Nicholas K. Foreman, Vladimir Amani, Michael H. Handler
Publikováno v:
Neuro Oncol
Background Medulloblastoma (MB) is a heterogeneous disease in which neoplastic cells and associated immune cells contribute to disease progression. We aimed to determine the influence of neoplastic and immune cell diversity on MB biology in patient s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbaf2ff178394dc8a552bbfe5677a870
https://europepmc.org/articles/PMC8804892/
https://europepmc.org/articles/PMC8804892/
Autor:
Vladyslav V. Vyazovskiy, L B Krone
This scientific commentary refers to ‘Local sleep-like cortical reactivity in the awake brain after focal injury’, by Sarasso et al. (doi:10.1093/brain/awaa338).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75066bb258132db4eb635831e69f91d5
https://doi.org/10.1093/brain/awaa396
https://doi.org/10.1093/brain/awaa396
Autor:
Judith Cossins, Kathryn Selby, Eduardo de Paula Estephan, Pedro M. Rodríguez Cruz, Pinki Munot, Stephanie Robb, Jan Senderek, Francina Munell, David Beeson, Sandeep Jayawant, Michio Hirano, Sithara Ramdas, Aisling Carr, Alfons Macaya, Marina Dusl, Edmar Zanoteli, Christian de Goede, Siddharth Banka, Jacqueline Palace, Harry Fraser, Mohammad Yahya Vahidi Mehrjardi, Ana Töpf, Reza Maroofin, Abigail Sage, Hans Lochmüller, Wei Wei Liu, Umbertina Conti Reed, Adnan Y. Manzur, Ravi Knight, Monika Hofer, M. Gratacos, Gabriel Chow
Publikováno v:
Brain
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Rodríguez Cruz, P M, Cossins, J, de Paula Estephan, E, Munell, F, Selby, K, Hirano, M, Maroofin, R, Mehrjardi, M Y V, Chow, G, Carr, A, Manzur, A, Robb, S, Munot, P, Wei Liu, W, Banka, S, Fraser, H, De Goede, C, Zanoteli, E, Conti Reed, U, Sage, A, Gratacos, M, Macaya, A, Dusl, M, Senderek, J, Töpf, A, Hofer, M, Knight, R, Ramdas, S, Jayawant, S, Lochmüller, H, Palace, J & Beeson, D 2019, ' The clinical spectrum of the congenital myasthenic syndrome resulting from COL13A1 mutations ', Brain : a journal of neurology, vol. 142, no. 6, pp. 1547-1560 . https://doi.org/10.1093/brain/awz107
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Rodríguez Cruz, P M, Cossins, J, de Paula Estephan, E, Munell, F, Selby, K, Hirano, M, Maroofin, R, Mehrjardi, M Y V, Chow, G, Carr, A, Manzur, A, Robb, S, Munot, P, Wei Liu, W, Banka, S, Fraser, H, De Goede, C, Zanoteli, E, Conti Reed, U, Sage, A, Gratacos, M, Macaya, A, Dusl, M, Senderek, J, Töpf, A, Hofer, M, Knight, R, Ramdas, S, Jayawant, S, Lochmüller, H, Palace, J & Beeson, D 2019, ' The clinical spectrum of the congenital myasthenic syndrome resulting from COL13A1 mutations ', Brain : a journal of neurology, vol. 142, no. 6, pp. 1547-1560 . https://doi.org/10.1093/brain/awz107
Mutations in COL13A1 cause synaptic basal lamina-associated congenital myasthenic syndrome type 19. Rodriguez Cruz et al. describe the clinical and genetic spectrum associated with COL13A1 mutations, and the key clinical features to look out for.
Publikováno v:
Brain
See Wekerle (doi:10.1093/brain/awz068) for a scientific commentary on this article. The peripheral immunological changes associated with conversion of multiple sclerosis to the secondary progressive phase are largely unknown. Kadowaki et al. demonstr
Autor:
Zalán Rajna, Heli Mattila, Niko Huotari, Timo Tuovinen, Johanna Krüger, Sebastian C Holst, Vesa Korhonen, Anne M Remes, Tapio Seppänen, Jürgen Hennig, Maiken Nedergaard, Vesa Kiviniemi
Publikováno v:
Brain
Accumulation of amyloid-β is a key neuropathological feature in brain of Alzheimer’s disease patients. Alterations in cerebral haemodynamics, such as arterial impulse propagation driving the (peri)vascular CSF flux, predict future Alzheimer’s di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79c07923f100e33904f2b1abd2e64412
http://urn.fi/urn:nbn:fi-fe2021083044614
http://urn.fi/urn:nbn:fi-fe2021083044614
Autor:
Meena Kumari, Paul T. Francis, Kevin Morgan, Jonathan P. Davies, Rebecca G. Smith, Leonard C. Schalkwyk, Emma Walker, Joe Burrage, Grant W. A. Neilson, Alan J. Thomas, Eilis Hannon, Jonathan Mill, Aisha Dahir, Gemma Shireby, Katie Lunnon, Keeley J. Brookes, Seth Love
Publikováno v:
Brain
Shireby, G L, Davies, J P, Francis, P T, Burrage, J, Walker, E M, Neilson, G W A, Dahir, A, Thomas, A J, Love, S, Smith, R G, Lunnon, K, Kumari, M, Schalkwyk, L C, Morgan, K, Brookes, K, Hannon, E & Mill, J 2020, ' Recalibrating the epigenetic clock : implications for assessing biological age in the human cortex ', Brain . https://doi.org/10.1093/brain/awaa334
Shireby, G L, Davies, J P, Francis, P T, Burrage, J, Walker, E M, Neilson, G W A, Dahir, A, Thomas, A J, Love, S, Smith, R G, Lunnon, K, Kumari, M, Schalkwyk, L C, Morgan, K, Brookes, K, Hannon, E & Mill, J 2020, ' Recalibrating the epigenetic clock : implications for assessing biological age in the human cortex ', Brain . https://doi.org/10.1093/brain/awaa334
Existing DNA methylation clocks are highly accurate in blood but are less precise when used in older samples or on brain tissue. Shireby et al. develop a novel epigenetic clock that performs optimally in human cortical tissue and has the potential to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0504283b10226f4cd412d4743b3702dd
https://irep.ntu.ac.uk/id/eprint/40540/7/1355119_a1132_Brookes.pdf
https://irep.ntu.ac.uk/id/eprint/40540/7/1355119_a1132_Brookes.pdf
Publikováno v:
Brain
Accumulation of neuronal α-synuclein is a prominent feature in Parkinson’s disease. More recently, such abnormal protein aggregation has been reported to spread from cell to cell and exosomes are considered as important mediators. The focus of suc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::421a25aae8237aa0d1ad4da1f9e131ec
https://europepmc.org/articles/PMC7241957/
https://europepmc.org/articles/PMC7241957/
Autor:
Juho Joutsa, Danielle Cooke, Matthew J. Burke, Louis Soussand, Michael D. Fox, Rami Burstein, Alexander L. Cohen
Publikováno v:
Brain
Inconsistent findings from migraine neuroimaging studies have limited attempts to localize migraine symptomatology. Novel brain network mapping techniques offer a new approach for linking neuroimaging findings to a common neuroanatomical substrate an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a52f1a062de8756b22a6bbc173da8076
https://europepmc.org/articles/PMC7009560/
https://europepmc.org/articles/PMC7009560/