Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Roger J. Packer"'
Autor:
Tess Inker, Brigitte C. Widemann, Roger J. Packer, Kathy Mullin, Maegan Sady, Mary Anne Toledo-Tamula, Allison del Castillo, Pamela L. Wolters, Kari Struemph, Marie Claire Roderick, Staci Martin, Victoria Collier, Michael Fisher, Karin S. Walsh, Iris Paltin
Publikováno v:
Neurology: Genetics
article-version (Version of Record) 3
article-version (Version of Record) 3
Background and ObjectivesNeurofibromatosis type 1 (NF1)-associated cognitive impairments carry significant lifelong morbidity. The lack of targeted biologic treatments remains a significant unmet need. We examine changes in cognition in patients with
Autor:
Carmelina Trimboli-Heidler, Rabia Idrees, Robert A. Avery, Marius George Linguraru, Awais Mansoor, Hiroshi Ishikawa, Roger J. Packer
Publikováno v:
Neurology. 87:2403-2407
Objective:To determine whether tumor size is associated with retinal nerve fiber layer (RNFL) thickness, a measure of axonal degeneration and an established biomarker of visual impairment in children with optic pathway gliomas (OPGs) secondary to neu
Autor:
Roger J. Packer, Robert A. Avery, Rabia Idrees, Marius George Linguraru, Elijah Biggs, Mohammad Alsharid, Awais Mansoor
Publikováno v:
Neurology. 86:2264-2270
To determine quantitative size thresholds for enlargement of the optic nerve, chiasm, and tract in children with neurofibromatosis type 1 (NF1).Children 0.5-18.6 years of age who underwent high-resolution T1-weighted MRI were eligible for inclusion.
Autor:
Roger J. Packer, Elizabeth M. Wells
Publikováno v:
CONTINUUM: Lifelong Learning in Neurology. 21:373-396
Pediatric brain tumors differ from those arising in adulthood. This article discusses the presentation, location, histology, new molecular understanding, therapy, and outcome of brain tumors in children.Improved biological understanding of pediatric
Autor:
Roger J. Packer, Mariarita Santi, Gilbert Vezina, John R. Crawford, Tobey J. MacDonald, D. A. LaFond, Brian R. Rood, John S. Myseros, Robert F. Keating
Publikováno v:
Neurology. 68:1668-1673
Objective: To describe the relationship between symptomatology and time to diagnosis of an institutional series of patients with CNS germ cell tumor (CNSGCT) over a 16-year period. Methods: Thirty consecutive patients newly diagnosed with CNSGCT (mea
Autor:
Frank M. Balis, Andrea Gillespie, Dusica Babovic-Vuksanovic, Elizabeth Fox, Jean B. Belasco, Nicholas J. Patronas, Mark W. Kieran, Seth M. Steinberg, Eva Dombi, Stewart Goldman, Jeffrey Solomon, Regina I. Jakacki, Bruce R. Korf, Brigitte C. Widemann, Roger J. Packer
Publikováno v:
Neurology. 68:643-647
Objective: To longitudinally analyze changes in plexiform neurofibroma (PN) volume in relation to age and body growth in children and young adults with neurofibromatosis type 1 and inoperable, symptomatic, or progressive PNs, using a sensitive, autom
Autor:
Kinji Ohno, Akira Tsujino, Xin-Ming Shen, Joan M. Brengman, Takayasu Fukudome, Andrew G. Engel, Darryl C. De Vivo, Roger J. Packer
Publikováno v:
Neurology. 59:1881-1888
Objective: To determine the molecular basis of a disabling congenital myasthenic syndrome (CMS) observed in two related and one unrelated Arab kinship. Background: CMS can arise from defects in presynaptic, synaptic basal lamina–associated, or post
Autor:
Joanne M. Hilden, Susan M. Blaney, Jaclyn A. Biegel, Anna J. Janss, Richard Heideman, Malcolm A. Smith, L B Rorke, Roger J. Packer, Jonathan L. Finlay, Gilbert Vezina, J. Russell Geyer, Larry E. Kun
Publikováno v:
Journal of Pediatric Hematology/Oncology. 24:337-342
Childhood atypical teratoid/rhabdoid tumor (AT/RT) of the central nervous system (CNS) is a recently described entity. Diagnosis is based on distinctive light microscopy and immuno-histochemical findings, coupled with molecular genetic analysis. Most
Autor:
Gilbert Vezina, A. Rubenstein, Roger J. Packer, Bruce R. Korf, J. Small, D. Viskochil, David H. Gutmann, R. A. Zimmerman
Publikováno v:
Neurology. 58:1461-1470
Neurofibromatosis type 1 (NF1) is one of the most common neurogenetic diseases affecting adults and children. Neurofibromas are one of the most common of the protean manifestations of NF1. Plexiform neurofibromas, which will frequently cause cosmetic
Autor:
Susanne M. Schmandt, Roger J. Packer
Publikováno v:
Current Opinion in Oncology. 12:194-198
The prognosis of pediatric low-grade gliomas is relatively favorable, but residual or unresectable tumors remain a challenge. Conventional radiation therapy is effective but may be associated with unacceptable sequelae in young children. Chemotherapy