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Publikováno v:
Current Opinion in Lipidology. 33:319-325
Purpose of reviewTo review recent developments in the field of cholesteryl ester transfer protein (CETP) inhibition from clinical trials and genomic analyses which have the potential to impact future clinical programs.Recent findingsCETP plays an imp
Publikováno v:
Current opinion in lipidology, vol 33, iss 5
Purpose of reviewThis review explores mechanisms by which gut-derived bacteriallipopolysaccharide (LPS) and oxidized phospholipids contribute to chronic systemic inflammation and atherosclerosis.Recent findingsGut-derived LPS enters through the small
Publikováno v:
Current Opinion in Lipidology. 33:289-294
Lipids and lipoproteins have long been known to contribute to atherosclerosis and cardiovascular calcification. One theme of recent work is the study of lipoprotein (a) [Lp(a)], a lipoprotein particle similar to LDL-cholesterol that carries a long ap
Autor:
Corey A, Scipione, Myron I, Cybulsky
Publikováno v:
Current Opinion in Lipidology. 33:271-276
To highlight recent conceptual and technological advances that have positioned the field to interrogate the cellular and molecular mechanisms contributing to the initiation of atherosclerosis, including intimal lipid accumulation, inflammation, and l
Publikováno v:
Current Opinion in Lipidology. 33:237-256
The reference method for low-density lipoprotein-cholesterol (LDL-C) quantitation is β-quantification, a technically demanding method that is not convenient for routine use. Indirect calculation methods to estimate LDL-C, including the Friedewald eq
Publikováno v:
Current Opinion in Lipidology. 33:219-226
Guidelines for cholesterol-lowering treatment generally include extensive review of epidemiological and clinical trial evidence. However, the next logical step, the translation of evidence into clinical advice, occurs not entirely by reasoning, but b
Autor:
John T, Wilkins, Anand, Rohatgi
Publikováno v:
Current Opinion in Lipidology. 33:264-269
A 'proteoform' is defined as one specific protein structural form that results from the combination of allelic variation, alternative RNA splicing, and/or posttranslational modifications (PTMs) in specific locations on the amino acid backbone. Apolip
Autor:
Trond P, Leren, Martin Prøven, Bogsrud
Publikováno v:
Current Opinion in Lipidology. 33:231-236
Patients with familial hypercholesterolemia (FH) have a markedly increased risk of premature cardiovascular disease. However, there are effective lipid-lowering therapies available to reduce the risk of cardiovascular disease. This makes it important
Publikováno v:
Current Opinion in Lipidology. 33:227-230
In recent years, there has been interest for the development of simplified diagnosis algorithms of dysbetalipoproteinemia (DBL) in order to avoid the complex testing associated with the Fredrickson criteria (reference method). The purpose of this rev
Autor:
Krauss, Ronald M
Publikováno v:
Curr Opin Lipidol
Current opinion in lipidology, vol 33, iss 3
Current opinion in lipidology, vol 33, iss 3
Purpose of reviewLevels of small, dense low-density lipoprotein (LDL) (sdLDL) particles determined by several analytic procedures have been associated with risk of atherosclerotic cardiovascular disease (ASCVD). This review focuses on the clinical si