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Autor:
Ali Ben Djoudi Ouadda, Benoit Coulombe, Rachid Essalmani, Robert Day, Artuela Çaku, Luc Galarneau, Delia Susan-Resiga, Kévin Ly, Emmanuelle Girard, Jadwiga Marcinkiewicz, Nabil G. Seidah, Miles H. Black, Diane Forget, François Corbin, Vincent S. Tagliabracci, Josée Hamelin, Alexandra Evagelidis, Marie-Soleil Gauthier
Publikováno v:
Arterioscler Thromb Vasc Biol
Objective: PCSK9 (proprotein convertase subtilisin-kexin 9) enhances the degradation of the LDLR (low-density lipoprotein receptor) in endosomes/lysosomes. This study aimed to determine the sites of PCSK9 phosphorylation at Ser-residues and the conse
Publikováno v:
Plastic and Reconstructive Surgery. 144:372-384
We investigated expression of prorenin receptor, angiotensin-converting enzyme, angiotensin II receptor 1, and angiotensin II receptor 2 by the embryonic stem cell-like population on the endothelium of the microvessels and perivascular cells within k
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Although the roles of alpha‐myosin heavy chain (α‐MyHC) and beta‐myosin heavy chain (β‐MyHC) proteins in cardiac contractility have long been appreciated, the biological contribution of another closely related sarcomeric myosin f
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Phenotypic switching in vascular smooth muscle cells (VSMCs) is involved in the pathogenesis of aortic dissection (AD). This study aims to explore the potential mechanisms of linc01278 during VSMC phenotypic switching. Methods and Results
Autor:
Hong Hu, Mark Maienschein-Cline, Muhammad Ashraf, Yan Wang, Ailia Ali, Yao Liang Tang, Wanling Xuan
Publikováno v:
Shock. 50:627-639
Cardiac progenitor cells (CPCs) being multipotent offer a promising source for cardiac repair due to their ability to proliferate and multiply into cardiac lineage cells. Here, we explored a novel strategy for human CPCs generation from human induced
Autor:
Hui Li, Xiayimaidan Gulireba, Jiang Wu, Hongyan Dai, Nie Yongmei, Amanguli Ruze, Dongyu Lei, Yiwei Zhao, Xin Zhao, Jing Li
Publikováno v:
Blood Coagulation & Fibrinolysis
Fractalkine (FKN) is a cytokine which plays an important role in atherosclerosis and other inflammatory diseases. Studies have shown that FKN induces integrin-independent leukocyte adhesion to primary endothelial cells under physiological flow condit
Autor:
Youssef Jalloul, Marwan M. Refaat
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Systemic inflammation is a strong predictor of atrial fibrillation. A key role for electrical remodeling is increasingly recognized, and experimental data suggest that inflammatory cytokines can directly affect connexins resulting in gap-j
Publikováno v:
Cornea. 37:633-640
Purpose The cell-cell adhesion molecules, cadherins and nectins, are involved in the formation of adherens junctions. However, involvement of nectins in the corneal endothelium has not yet been established. This study investigated the involvement of
Publikováno v:
NeuroReport. 28:1225-1231
The aim of this study was to perform neural differentiation of mesenchymal stem cells derived from Wharton's jelly of human umbilical cord (HUMSCs) and explore the role of miR-20b and miR-106a, which may regulate Neurogenin-2 (Ngn2) expression during
Publikováno v:
Cornea. 36:S41-S45
Because human corneal endothelial cells (HCECs) do not proliferate once the endothelial monolayer has formed, corneal wound healing is believed to be mediated by cell enlargement or migration, rather than by proliferation. However, the cellular mecha