Zobrazeno 1 - 10
of 1 385
pro vyhledávání: ''
Autor:
Yiming Jiang, Frank J. Gonzalez, Hua Li, Ruimin Wang, Shicheng Fan, Xiao Yang, Aijuan Qu, Huichang Bi, Jianing Tian, Min Huang, Yue Gao, Shuguang Zhu, Xinpeng Yao, Tomoki Yagai, Guomin Xie
Publikováno v:
Hepatology
BACKGROUND AND AIMS: Peroxisome proliferator–activated receptor α (PPARα, NR1C1) is a ligand-activated nuclear receptor involved in the regulation of lipid catabolism and energy homeostasis. PPARα activation induces hepatomegaly and plays an imp
Autor:
C Steichen, T. Lambert, Anne Dubart-Kupperschmitt, J M Heslan, Antonietta Messina, E. Luce, M Allouche, Olivier D. Christophe, Anne Weber, Tuan Huy Nguyen
Publikováno v:
Hepatology. 75:866-880
Pluripotent stem cell-derived hepatocytes differentiated in monolayer culture are known to have more fetal than adult hepatocyte characteristics. If numerous studies tend to show that this immature phenotype might not necessarily be an obstacle to th
Autor:
Kim A. Dora, Christopher J Garland
Publikováno v:
Journal of Cardiovascular Pharmacology. 78:S3-S12
Endothelium-derived hyperpolarizing factor (EDHF) was envisaged as a chemical entity causing vasodilation by hyperpolarizing vascular smooth muscle (VSM) cells and distinct from nitric oxide (NO) ([aka endothelium-derived relaxing factor (EDRF)]) and
Publikováno v:
Current Opinion in Lipidology. 33:39-46
PURPOSE OF REVIEW Over the last two decades, evolving discoveries around angiopoietin-like (ANGPTL) proteins, particularly ANGPTL3, ANGPTL4, and ANGPTL8, have generated significant interest in understanding their roles in fatty acid (FA) metabolism.
Autor:
Wen-Chao Liu, Na Liu, Yan Wang, Chen Huang, Yan-Fang Li, Hao Wang, Xiao-Gang Li, Min Deng, Yan-Jie Yin, Xiu-Yuan Hao
Publikováno v:
Chinese Medical Journal, Vol 134, Iss 20, Pp 2457-2464 (2021)
Chinese Medical Journal
Chinese Medical Journal
Background:. Investigations of the pathogenic mechanisms in motor neurons (MNs) derived from amyotrophic lateral sclerosis (ALS) disease-specific induced pluripotent stem (iPS) cell lines could improve understanding of the issues affecting MNs. There
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology
Supplemental Digital Content is available in the text.
Objective: Endothelial cells (ECs) that form the innermost layer of all vessels exhibit heterogeneous cell behaviors and responses to pro-angiogenic signals that are critical for vascular sp
Objective: Endothelial cells (ECs) that form the innermost layer of all vessels exhibit heterogeneous cell behaviors and responses to pro-angiogenic signals that are critical for vascular sp
Autor:
Belay Tesfamariam
Publikováno v:
Journal of Cardiovascular Pharmacology. 78:515-522
Endothelial cells adhere to one another through junctional structures formed by intercellular adhesion molecules. These intercellular proteins regulate barrier function in response to the hemodynamic shear rate and enable the selective passage of sol
Autor:
Jacquelyn J. Maher, Aras N. Mattis, Ke Liu, Tao Su, Caitlin Peaslee, Sneha Rao, Cristina Esteva-Font, Julie B. Sneddon, Antonio Munoz-Howell, Zhe Liu, Caroline C. Duwaerts, Marisa W. Medina
Publikováno v:
Hepatology (Baltimore, Md.), vol 74, iss 4
Hepatology
Hepatology
BACKGROUND AND AIMS: Induced pluripotent stem cells (iPSCs) provide an important tool for the generation of patient-derived cells, including hepatocyte-like cells, by developmental cues through an endoderm intermediate. However, most iPSC lines fail
Autor:
Joshua M. Gorham, Christine E. Seidman, Christopher S. Chen, Jonathan G. Seidman, Subramanian Sundaram, Christopher N. Toepfer, Radhika Agarwal, Jourdan K. Ewoldt, Steven P. Gygi, Joao A. Paulo, Steven R. DePalma, Qi Zhang, Anant Chopra
Publikováno v:
Circ Res
Rationale: Dominant heterozygous variants in filamin C ( FLNC ) cause diverse cardiomyopathies, although the underlying molecular mechanisms remain poorly understood. Objective: We aimed to define the molecular mechanisms by which FLNC variants alter
Autor:
Joyce Bischoff, Zahra Alvandi
Publikováno v:
Arterioscler Thromb Vasc Biol
Endothelial-to-mesenchymal transition is a dynamic process in which endothelial cells suppress constituent endothelial properties and take on mesenchymal cell behaviors. To begin the process, endothelial cells loosen their cell-cell junctions, degrad