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Publikováno v:
Journal of Cardiovascular Pharmacology. 79:335-341
This study aimed to investigate the role of ginsenoside Rh1 in regulating the proliferation, apoptosis, and oxidative stress in oxidized low-density lipoprotein (ox-LDL)-treated human vascular endothelial cells (VECs) and the underlying mechanisms. V
Autor:
Yulin He, Tingyu Lan, Thekla Kemper, Yongfang Jiang, Mengji Lu, Xueyu Wang, Yong Lin, Jia Li, Bin Jiang, Zhongji Meng, Zhiqiang Wei, Bin Cheng
Publikováno v:
Hepatology. 75:438-454
Background & aims Hepatitis B virus (HBV) infection has been reported to trigger endoplasmic reticulum (ER) stress and initiate autophagy. However, how ER stress and autophagy influence HBV production remains elusive. Here, we studied the effect of t
Autor:
Keith P. Gates, P. Duc Si Dong, Jonathan Matalonga, Jiaye He, Chong Chen, Lindsey Barske, Jan Huisken, Dan Cao, Yi Yang, Chengjian Zhao, Alyssa Graves, Xiangyu Pan, Joseph J. Lancman
Publikováno v:
Hepatology
Alagille Syndrome (ALGS) is a congenital disorder caused by mutations in the Notch ligand gene JAGGED1, leading to neonatal loss of intrahepatic duct (IHD) cells and cholestasis. Cholestasis can resolve in certain patients with ALGS, suggesting regen
Autor:
Yiming Jiang, Frank J. Gonzalez, Hua Li, Ruimin Wang, Shicheng Fan, Xiao Yang, Aijuan Qu, Huichang Bi, Jianing Tian, Min Huang, Yue Gao, Shuguang Zhu, Xinpeng Yao, Tomoki Yagai, Guomin Xie
Publikováno v:
Hepatology
BACKGROUND AND AIMS: Peroxisome proliferator–activated receptor α (PPARα, NR1C1) is a ligand-activated nuclear receptor involved in the regulation of lipid catabolism and energy homeostasis. PPARα activation induces hepatomegaly and plays an imp
Autor:
Lan Bai, Wen-Jie Zhao, Tengfei Ma, Manli Hu, Fengjiao Hu, Chongshu Jian, Han Tian, Xu Cheng, Jiajun Fu, Yanfang Zhang, Juan Yang, Zhi-Gang She, Yan-Xiao Ji, Junjie Zhou, Xiao-Jing Zhang, Peng Zhang, Yan Zhang, Jingwei Jiang, Hongliang Li
Publikováno v:
Hepatology. 75:403-418
Background & aims Although the prevalence of nonalcoholic fatty liver disease (NAFLD) has risen dramatically to 25% of the adult population worldwide, there are as yet no approved pharmacological interventions for the disease due to uncertainty about
Autor:
C Steichen, T. Lambert, Anne Dubart-Kupperschmitt, J M Heslan, Antonietta Messina, E. Luce, M Allouche, Olivier D. Christophe, Anne Weber, Tuan Huy Nguyen
Publikováno v:
Hepatology. 75:866-880
Pluripotent stem cell-derived hepatocytes differentiated in monolayer culture are known to have more fetal than adult hepatocyte characteristics. If numerous studies tend to show that this immature phenotype might not necessarily be an obstacle to th
Autor:
Dong-bao Chen, Jin Bai
Publikováno v:
Hypertension
Pregnancy and VEGF (vascular endothelial growth factor) stimulate uterine artery endothelial cell (UAEC) hydrogen sulfide production via selectively upregulating CBS (cystathionine β-synthase) but not CSE (cystathionine γ-lyase) expression. This st
Autor:
Kim A. Dora, Christopher J Garland
Publikováno v:
Journal of Cardiovascular Pharmacology. 78:S3-S12
Endothelium-derived hyperpolarizing factor (EDHF) was envisaged as a chemical entity causing vasodilation by hyperpolarizing vascular smooth muscle (VSM) cells and distinct from nitric oxide (NO) ([aka endothelium-derived relaxing factor (EDRF)]) and
Autor:
Kathleen M. Ruppel, John Perrino, Daniel Bernstein, Kristina B. Kooiker, Tiffany T. Koyano, Rahel A. Woldeyes, Joseph C. Wu, Joseph Woo, Kévin Contrepois, Robyn Fong, Mingming Zhao, Alison Schroer Vander Roest, James A. Spudich, Ning Ma, Sara Ranjbarvaziri, Michael Snyder, Sushma Reddy, Wah Chiu, Mathew Ellenberger, Lei Tian, Frandics P. Chan, Gavin M. Traber, Giovanni Fajardo
Publikováno v:
Circulation, vol 144, iss 21
Circulation
Circulation
Background: Hypertrophic cardiomyopathy (HCM) is a complex disease partly explained by the effects of individual gene variants on sarcomeric protein biomechanics. At the cellular level, HCM mutations most commonly enhance force production, leading to
Publikováno v:
Curr Opin Lipidol
Purpose of review Nonalcoholic fatty liver disease (NAFLD) is a common comorbidity and has wide ranging extrahepatic manifestations, including through cardiometabolic pathways. As such, there is growing interest in the impact of NAFLD on cerebrovascu