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Autor:
Dong-bao Chen, Jin Bai
Publikováno v:
Hypertension
Pregnancy and VEGF (vascular endothelial growth factor) stimulate uterine artery endothelial cell (UAEC) hydrogen sulfide production via selectively upregulating CBS (cystathionine β-synthase) but not CSE (cystathionine γ-lyase) expression. This st
Autor:
Kathleen M. Ruppel, John Perrino, Daniel Bernstein, Kristina B. Kooiker, Tiffany T. Koyano, Rahel A. Woldeyes, Joseph C. Wu, Joseph Woo, Kévin Contrepois, Robyn Fong, Mingming Zhao, Alison Schroer Vander Roest, James A. Spudich, Ning Ma, Sara Ranjbarvaziri, Michael Snyder, Sushma Reddy, Wah Chiu, Mathew Ellenberger, Lei Tian, Frandics P. Chan, Gavin M. Traber, Giovanni Fajardo
Publikováno v:
Circulation, vol 144, iss 21
Circulation
Circulation
Background: Hypertrophic cardiomyopathy (HCM) is a complex disease partly explained by the effects of individual gene variants on sarcomeric protein biomechanics. At the cellular level, HCM mutations most commonly enhance force production, leading to
Publikováno v:
Journal of Cardiovascular Pharmacology. 78:534-543
Excessive proliferation and migration of human vascular smooth muscle cells (HVSMCs) induced by oxidized low-density lipoprotein (ox-LDL) are important pathological features of atherosclerosis. Emerging evidence indicates that circular RNAs deregulat
Publikováno v:
Journal of Cardiovascular Pharmacology. 78:228-234
Epicardial adipose tissue (EAT) dysfunction mediates chronic inflammation by regulating inflammation-related adipokines and cytokines, and it further promotes coronary artery disease (CAD) development. CD40L/CD40 is involved in multiple inflammatory
Autor:
Antonella Barreca, Emilio Hirsch, Gennaro Salvidio, Dario Roccatello, Marilena Durazzo, Beatrice Corbetta, Valentina Audrito, Roberto Gambino, Alessandro Corbelli, Stefania Bruno, Stefania Bellini, Shunsuke Kimura, Giovanni Camussi, Gabriella Gruden, Fabio Fiordaliso, Hiroshi Ohno, Mauro Papotti, Koji Hase, Miriam Martini, Silvia Deaglio, Gian Marco Ghiggeri, Federica Barutta
Publikováno v:
J Am Soc Nephrol
Background Podocyte dysfunction and loss are major determinants in the development of proteinuria. FSGS is one of the most common causes of proteinuria, but the mechanisms leading to podocyte injury or conferring protection against FSGS remain poorly
Publikováno v:
Current Opinion in Lipidology. 32:62-69
Purpose of review The aim of this study was to briefly summarize the contribution of the PREDIMED (PREvencion con DIeta MEDiterranea) trial on cardiovascular evidence and examine in depth its groundbreaking trajectory.PREDIMED was conducted during 20
Publikováno v:
Pain
Next generation transcriptomics in combination with imaging-based approaches have emerged as powerful tools for the characterization of dorsal root ganglion (DRG) neuronal subpopulations. The mouse DRG has been well-characterized by many independentl
Autor:
Aleksandra Frankow, Andrew C. Newby, Jason L. Johnson, Christopher L. Jackson, Sarah J George, Karina Di Gregoli, Rosaria Bianco, Michelle Somerville, Aniita C. Thomas
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology
Supplemental Digital Content is available in the text.
Objective: Galectin-3 (formerly known as Mac-2), encoded by the LGALS3 gene, is proposed to regulate macrophage adhesion, chemotaxis, and apoptosis. We investigated the role of galectin-3 in
Objective: Galectin-3 (formerly known as Mac-2), encoded by the LGALS3 gene, is proposed to regulate macrophage adhesion, chemotaxis, and apoptosis. We investigated the role of galectin-3 in
Publikováno v:
Spine. 45:E1216-E1224
Study design mRNA analysis. Objective The aim of this study was to identify differentially expressed genes (DEGs) in disc degeneration, analyze the potential biological functions of DEGs, and screen for a new target to prevent the degeneration. Summa
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Phenotypic switching in vascular smooth muscle cells (VSMCs) is involved in the pathogenesis of aortic dissection (AD). This study aims to explore the potential mechanisms of linc01278 during VSMC phenotypic switching. Methods and Results