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Publikováno v:
Curr Opin Lipidol
Current opinion in lipidology, vol 32, iss 5
Current opinion in lipidology, vol 32, iss 5
PURPOSE OF REVIEW: This paper reviews the mechanisms of high density lipoprotein cholesterol immunomodulation in the context of the mechanisms of chronic inflammation and immunosuppression causing persistent inflammation, immunosuppression, and catab
Publikováno v:
Current Opinion in Lipidology. 32:183-190
Purpose of review Sodium-glucose cotransporter 2 (SGLT2) inhibitors are widely used antihyperglycemic drugs that show remarkable cardiorenal protective effects in patients with or without type 2 diabetes. Furthermore, they are effective among patient
Autor:
Mafalda Bourbon, Joana Rita Chora
Publikováno v:
Current Opinion in Lipidology. 32:96-102
Purpose of review To collect evidence on statin pharmacogenomics, and review what is known in this field for familial hypercholesterolemia (FH) patients. Recent findings There are well-known associations between specific single nucleotide polymorphis
Publikováno v:
J Am Soc Nephrol
In the past few decades, sphingolipids and sphingolipid metabolites have gained attention because of their essential role in the pathogenesis and progression of kidney diseases. Studies in models of experimental and clinical nephropathies have descri
Autor:
Michael Bukrinsky, Nigora Mukhamedova, Seth J. Field, Michael Ditiatkovski, Peter J. Meikle, Soo-Ho Choi, Kevin Huynh, Hann Low, Ryunosuke Ohkawa, Luciano Dos Santos Aggum Capettini, Yury I. Miller, Yining Xia, Dmitri Sviridov, Stephen H. Cody, Irena Carmichael
Publikováno v:
Arterioscler Thromb Vasc Biol
Objective: AIBP (apolipoprotein A-I binding protein) is an effective and selective regulator of lipid rafts modulating many metabolic pathways originating from the rafts, including inflammation. The mechanism of action was suggested to involve stimul
Autor:
Nigel Capps, Handrean Soran, Ian McDowell, Andrew Neil, Jackie A. Cooper, Steve E. Humphries, Paul N. Durrington
Publikováno v:
Current Opinion in Lipidology. 31:167-175
Purpose of review The role of non-HDL-C in the identification and management of lipid disorders is not clearly defined, although UK guidelines recommend its wider use in assessing the need for lipid-lowering therapy and as a treatment target. Recent
Autor:
Om P. Ganda
Publikováno v:
Current Opinion in Lipidology. 31:238-245
Purpose of review Substantial risk of ASCVD events persists despite intensive statin therapy and other agents to lower LDL-C. The optimal way to address other elements of dyslipidemia, such as triglyceride-rich particles (TRL) and when to treat has r
Publikováno v:
Current Opinion in Lipidology. 31:111-118
PURPOSE OF REVIEW: This review explores the concepts of monogenic and the so-called polygenic familial hypercholesterolemia and how the identification of familial hypercholesterolemia as a monogenic condition and its separation from polygenic primary
Autor:
Ling-Chao Yang, Na Feng, Yong Chen, Fang Liu, Shuang-Xi Zhu, Xiang-Fei Feng, Xue-Juan Yang, Xue-Song Ding
Publikováno v:
Journal of Cardiovascular Pharmacology. 75:45-53
Atherosclerosis is a chronic inflammation condition resulting from the interaction between lipoproteins, monocyte-derived macrophages, T lymphocytes, and other cellular elements in the arterial wall. Macrophage-derived foam cells play a key role in b
Autor:
Jean-Charles Fruchart, Raul D. Santos
Publikováno v:
Current Opinion in Lipidology. 30:419-427
Atherogenic dyslipidaemia, characterized by high plasma triglycerides (a surrogate for triglyceride-rich remnant lipoproteins) and low high-density lipoprotein cholesterol (HDL-C), is prevalent in patients with type 2 diabetes mellitus (T2DM) and con