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Autor:
Kim A. Dora, Christopher J Garland
Publikováno v:
Journal of Cardiovascular Pharmacology. 78:S3-S12
Endothelium-derived hyperpolarizing factor (EDHF) was envisaged as a chemical entity causing vasodilation by hyperpolarizing vascular smooth muscle (VSM) cells and distinct from nitric oxide (NO) ([aka endothelium-derived relaxing factor (EDRF)]) and
Autor:
Belay Tesfamariam
Publikováno v:
Journal of Cardiovascular Pharmacology. 78:515-522
Endothelial cells adhere to one another through junctional structures formed by intercellular adhesion molecules. These intercellular proteins regulate barrier function in response to the hemodynamic shear rate and enable the selective passage of sol
Publikováno v:
Transplantation
Activation of porcine endothelial cells (PECs) is the mechanistic centerpiece of xenograft rejection. This study sought to characterize the immuno-phenotype of human T cells in response to PECs and to explore the immuno-modulation of B7 and mammalian
Autor:
Suhnrita Chaudhuri, Jugajyoti Baruah, Ryan T. Hitzman, Victoria Mastej, Kishore K. Wary, Isabella M.B. Ribeiro, Cassondra Axen
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology
Supplemental Digital Content is available in the text.
Objective: Nanog is expressed in adult endothelial cells (ECs) at a low-level, however, its functional significance is not known. The goal of our study was to elucidate the role of Nanog in
Objective: Nanog is expressed in adult endothelial cells (ECs) at a low-level, however, its functional significance is not known. The goal of our study was to elucidate the role of Nanog in
Autor:
Cindy Casteels, Tatiane Gorski, E. Dale Abel, Paola Gilardoni, Koen Van Laere, Melissa García-Caballero, Johanna Schaffenrath, Zheng Fan, Koen Veys, Joanna Kalucka, Annika Keller, Nadine V. Conchinha, Moheb Ghobrial, Gino De Smet, Thomas Wälchli, Peter Carmeliet, Anna Rita Cantelmo, Aline Seuwen, Sarah-Maria Fendt, Aileen Schroeter, Ann Bouché, Felix Schlegel, Katrien De Bock, Kim Vriens, Raphaela Ardicoglu, Melissa Crabbé, Ilse Julia Smolders
Publikováno v:
Veys, K, Fan, Z, Ghobrial, M, Bouché, A, García-Caballero, M, Vriens, K, Conchinha, N V, Seuwen, A, Schlegel, F, Gorski, T, Crabbé, M, Gilardoni, P, Ardicoglu, R, Schaffenrath, J, Casteels, C, De Smet, G, Smolders, I, Van Laere, K, Abel, E D, Fendt, S M, Schroeter, A, Kalucka, J, Cantelmo, A R, Wälchli, T, Keller, A, Carmeliet, P & De Bock, K 2020, ' Role of the GLUT1 Glucose Transporter in Postnatal CNS Angiogenesis and Blood-Brain Barrier Integrity ', Circulation Research, vol. 127, no. 4, pp. 466-482 . https://doi.org/10.1161/CIRCRESAHA.119.316463
Circulation Research
Circulation Research, 127 (4)
Circulation Research
Circulation Research, 127 (4)
Supplemental Digital Content is available in the text.
Rationale: Endothelial cells (ECs) are highly glycolytic and generate the majority of their energy via the breakdown of glucose to lactate. At the same time, a main role of ECs is to allow t
Rationale: Endothelial cells (ECs) are highly glycolytic and generate the majority of their energy via the breakdown of glucose to lactate. At the same time, a main role of ECs is to allow t
Autor:
Xinbo Zhang, Carlos Fernández-Hernando, William C. Sessa, Cristina M. Ramírez, Marta Torrecilla-Parra, Ana Maria Cuervo, Yajaira Suárez, Binod Aryal, Xinran Liu, Antonio Diaz, Julio Madrigal-Matute
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology
Supplemental Digital Content is available in the text.
Objective: Endothelial Cav-1 (caveolin-1) expression plays a relevant role during atherogenesis by controlling NO production, vascular inflammation, LDL (low-density lipoprotein) transcytosi
Objective: Endothelial Cav-1 (caveolin-1) expression plays a relevant role during atherogenesis by controlling NO production, vascular inflammation, LDL (low-density lipoprotein) transcytosi
Publikováno v:
Plastic and Reconstructive Surgery. 144:372-384
We investigated expression of prorenin receptor, angiotensin-converting enzyme, angiotensin II receptor 1, and angiotensin II receptor 2 by the embryonic stem cell-like population on the endothelium of the microvessels and perivascular cells within k
Autor:
Robert Drury, Chrissy Guidry, Jacob Packer, Marcus Hoof, Juan Duchesne, Jessica Friedman, Olan Jackson-Weaver, Laura Rodriguez, Alison Smith
Publikováno v:
Journal of Trauma and Acute Care Surgery. 87:1070-1076
Ischemia/reperfusion injury (IRI) has been shown to cause endothelial glycocalyx (EG) damage.Whether the hypoxic/ischemic insult or the oxidative and inflammatory stress of reperfusion plays a greater part in glycocalyx damage is not known. Furthermo
Autor:
Lingfeng Qin, Dan Jane-wit, Guangxin Li, Caodi Fang, Catherine B. Xie, George Tellides, Nancy C. Kirkiles-Smith, Jordan S. Pober
Publikováno v:
Circulation Research. 124:1747-1759
Rationale: Complement activation contributes to multiple immune-mediated pathologies. In late allograft failure, donor-specific antibody deposits complement membrane attack complexes (MAC) on graft endothelial cells (ECs), substantially increasing th
Autor:
Russell Simpson, Mei Mei Wong, Xuechong Hong, Jiacheng Deng, Ting Chen, Li Zhang, Baoqi Yu, Eirini Karamariti, Aijuan Qu, Qingbo Xu, Yanhua Hu, Wenduo Gu, Yutao Wu
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 39:765-773
Objective— To determine the role of a cytokine-like protein DKK3 (dikkopf-3) in directly transdifferentiating fibroblasts into endothelial cells (ECs) and the underlying mechanisms. Approach and Results— DKK3 overexpression in human fibroblasts u