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Autor:
Kathleen M. Ruppel, John Perrino, Daniel Bernstein, Kristina B. Kooiker, Tiffany T. Koyano, Rahel A. Woldeyes, Joseph C. Wu, Joseph Woo, Kévin Contrepois, Robyn Fong, Mingming Zhao, Alison Schroer Vander Roest, James A. Spudich, Ning Ma, Sara Ranjbarvaziri, Michael Snyder, Sushma Reddy, Wah Chiu, Mathew Ellenberger, Lei Tian, Frandics P. Chan, Gavin M. Traber, Giovanni Fajardo
Publikováno v:
Circulation, vol 144, iss 21
Circulation
Circulation
Background: Hypertrophic cardiomyopathy (HCM) is a complex disease partly explained by the effects of individual gene variants on sarcomeric protein biomechanics. At the cellular level, HCM mutations most commonly enhance force production, leading to
Publikováno v:
Curr Opin Lipidol
Purpose of review Nonalcoholic fatty liver disease (NAFLD) is a common comorbidity and has wide ranging extrahepatic manifestations, including through cardiometabolic pathways. As such, there is growing interest in the impact of NAFLD on cerebrovascu
Publikováno v:
Current Opinion in Rheumatology. 34:46-53
Propose of review To summarize the evidence that suggests that osteoarthritis (OA) is a mitochondrial disease. Recent findings Mitochondrial dysfunction together with mtDNA damage could contribute to cartilage degradation via several processes such a
Publikováno v:
Journal of Craniofacial Surgery. 33:971-984
The de novo induction of bone has always been a fascinating phenomenon, keeping skeletal reconstructionists and cellular developmental biologists continuously engaged to finally provide a molecular and cellular approach to the induction of bone forma
Publikováno v:
Current Opinion in Lipidology
Purpose of review Antisense oligomers (ASOs) have been available for decades: however, only recently have these molecules been applied clinically. This review aims to discuss the possible development of antisense-mediated splice correction therapies
Autor:
Qinghua Cui, Jin-Peng Sun, Yiting Jia, Yi Fu, Nan Xie, Fang Yu, Guizhen Zhao, Wei Kong, Ma Zihan, Baihui Ma, Weihao Li, Yuan Zhou, Chenfeng Mao
Publikováno v:
Circulation. 144:1244-1261
Background: How the extracellular matrix (ECM) microenvironment modulates the contractile phenotype of vascular smooth muscle cells (VSMCs) and confers vascular homeostasis remains elusive. Methods: To explore the key ECM proteins in the maintenance
Autor:
Dorothy Graham, Frederick J. Raal
Publikováno v:
Current Opinion in Lipidology. 32:370-377
Purpose of review To highlight quandaries and review options for the management of familial hypercholesterolemia (FH) during pregnancy. Recent findings Women with FH face barriers to effective care and consequently face significant disease related lo
Autor:
Jianxin Wang, Min Li, Li Tang, Bao Nguyen, Jun Wang, James F. Martin, Xiaolei Zhao, Todd Heallen, Shijie Liu
Publikováno v:
Circ Res
Rationale: During neonatal heart regeneration, the fibrotic response, which is required to prevent cardiac rupture, resolves via poorly understood mechanisms. Deletion of the Hippo pathway gene Sav in adult cardiomyocytes increases Yap activity and p
Publikováno v:
Current Opinion in Rheumatology. 33:495-504
PURPOSE OF REVIEW Primary cilia, the antenna-like organelles on most mammalian cells, host key components of multiple morphogen signal transduction pathways. Mutations in genes responsible for primary cilia assembly and function generally result in p
Autor:
Tong Liu, Yuheng Li, Yan-Zhong Chang, Jinping Song, Hailin Song, Junmeng Zheng, Wenjuan Xing, Jielin Nie, Caizhi Liu, Ruikai Du, Zifan Liu, Weijia Sun, Yinlong Zhao, Guanghan Kan, Zizhong Liu, Wei Liu, Xiaoyan Jin, Yingxian Li, Junjie Pan, Dingsheng Zhao, Youyou Li, Guohui Zhong, Shukuan Ling, Jianwei Li, Xinxin Yuan, Yixin Jia, Xingcheng Gao
Publikováno v:
Circulation. 144:694-711
Background: Without adequate treatment, pathological cardiac hypertrophy induced by sustained pressure overload eventually leads to heart failure. WWP1 (WW domain–containing E3 ubiquitin protein ligase 1) is an important regulator of aging-related