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Publikováno v:
Journal of Hypertension. 40:117-127
Background We earlier demonstrated that vascular smooth muscle cells (VSMC) from spontaneously hypertensive rats (SHR) exhibit the overexpression of Giα proteins and hyperproliferation that is attributed to the enhanced levels of endogenous II angio
Autor:
Jing Fang, Megan T. Lewno, Huabo Su, Taixing Cui, Nirmal Parajuli, Wenjuan Wang, Jianqiu Zou, Penglong Wu, Bo Pan, Jinbao Liu, R. John Mayer, Zongwen Tian, Xuejun Wang, Lynn Bedford, Jie Li
Publikováno v:
Autophagy
Rationale: The ubiquitin-proteasome system (UPS) and the autophagic-lysosomal pathway are pivotal to proteostasis. Targeting these pathways is emerging as an attractive strategy for treating cancer. However, a significant proportion of patients who r
Autor:
Limei Liu, Shi Jia, Chunling Xu, Ruxia Liu, Xingzhong Zhang, Yangpo Cao, Qihua He, Jingjing Ye, Xue Qiao, Yingying Liu, Lin Weng, Cheng-Lin Zhang, Ming Zheng
Publikováno v:
Circulation Research. 125:728-743
Rationale: The constrained mitochondria in cardiomyocytes communicate with each other, through mitochondrial kissing or nanotunneling, forming a dynamically continuous network to share content and transfer signals. However, the molecular mechanism of
Publikováno v:
Journal of Hypertension. 36:2369-2379
AIMS High-salt diet is linked to hypertension, and prenatal high-salt diet increases the risk of cardiovascular diseases in the offspring. The present study investigated whether and how prenatal high-salt diet influenced nitric oxide-mediated vasodil
Autor:
Joshua M. Sante, Jin Qian, Toshie Saito, Olga Manouvakhova, Brian B. Graham, Allen B. Tu, Rasa Tamosiuniene, Mark R. Nicolls, Paul Mesange, Norbert F. Voelkel, Aida Habtezion, Desmond J. Fitzgerald, Laure Aurelian, Linh P. Nguyen, Yu-Chun Lin, Marlene Rabinovitch, Amir Luria, Mrinmoy Sanyal
Publikováno v:
Circulation Research. 122:1689-1702
Rationale: Pulmonary arterial hypertension (PH) is a life-threatening condition associated with immune dysregulation and abnormal regulatory T cell (Treg) activity, but it is currently unknown whether and how abnormal Treg function differentially aff
Autor:
Qiang Yu, Wei-Zhong Wang, Ya-Hong Yang, Wu Zhaotang, Tan Xing, Wang Yangkai, Ru-Wen Zhang, Wen-Jun Yuan, Qi-Kuan Hu
Publikováno v:
Journal of Hypertension. 34:993-1004
Objective Centrally acting antihypertensive action of moxonidine is a result of activation of Imidazoline-1 receptor (I1R) in the rostral ventrolateral medulla (RVLM). Hypertension shows an increase in reactive oxygen species (ROS) in the RVLM. The p
Autor:
Masaki Yamato, Masafumi Kitakaze, Yoshihiro Asano, Takashi Matsuzaki, Keiji Okuda, Yulin Liao, Brent A. French, Tetsuo Minamino, Ryo Araki, Hiroshi Asanuma, Hai Ying Fu, Shota Tsuchida, Shoji Sanada, Masanori Asakura, Yasushi Sakata
Publikováno v:
Circulation Research. 118:798-809
Rationale: Doxorubicin is an effective chemotherapeutic agent for cancer, but its use is often limited by cardiotoxicity. Doxorubicin causes endoplasmic reticulum (ER) dilation in cardiomyocytes, and we have demonstrated that ER stress plays importan
Autor:
Yong-Hoon Kim, Chul-Ho Lee, Hueng-Sik Choi, Jung-Ran Noh, Jung Hwan Hwang, Gil-Tae Gang, Kyeong-Hoon Jeong, In Kyu Lee, Tae Hwan Kwak, Kyung-Shim Kim, Won Keun Oh
Publikováno v:
Journal of Hypertension. 32:306-317
Aims Guanosine 5'-triphosphate cyclohydrolase-1 (GTPCH-1) is a rate-limiting enzyme in de-novo synthesis of tetrahydrobiopterin (BH4), an essential cofactor for endothelial nitric oxide synthase (eNOS) coupling. Adenosine 5'-monophosphate-activated p
Autor:
Xian Wu Cheng, Kohji Sato, Masafumi Kuzuya, Toyoaki Murohara, Kyosuke Takeshita, Lina Hu, Akihiro Hirashiki, Zhe Huang, Aiko Inoue, Takeshi Sasaki, Haizhen Song, Ping Li, Kenji Okumura, Guo-Ping Shi
Publikováno v:
Journal of Hypertension. 29:542-552
The mineralocorticoid receptor has been implicated in the pathogenesis of chronic cardiorenal disease. Statins improve renal remodeling and dysfunction in patients with proteinuric kidney diseases. We aimed to clarify the beneficial effects and mecha
Autor:
Arne, Hansen, Alexandra, Eder, Marlene, Bönstrup, Marianne, Flato, Marco, Mewe, Sebastian, Schaaf, Bülent, Aksehirlioglu, Alexander P, Schwoerer, Alexander, Schwörer, June, Uebeler, Thomas, Eschenhagen
Publikováno v:
Circulation Research. 107:35-44
Rationale : Tissue engineering may provide advanced in vitro models for drug testing and, in combination with recent induced pluripotent stem cell technology, disease modeling, but available techniques are unsuitable for higher throughput. Objective