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Autor:
Jennifer C. Price, Joseph B. Margolick, Chloe L. Thio, Ravi Varadhan, Frank J. Palella, Lawrence A. Kingsley, Jenny Pena Dias, Jordan E. Lake, Sabina A. Haberlen, Shehzad Basaria, Adrian S. Dobs, Todd T. Brown
Publikováno v:
J Acquir Immune Defic Syndr
BACKGROUND Sex hormone-binding globulin (SHBG) is a glycoprotein that regulates sex hormone bioavailability and increases with age in the general population. SHBG concentrations are higher in people with HIV, a population in whom accelerated aging ha
Autor:
Yuhki Sakuraoka, Yukihiro Iso, Keiichi Kubota, Takamune Yamaguchi, Shozo Mori, Takayuki Shimizu, Kyung Hwa Park, Takatsugu Matsumoto, Taku Aoki, Takayuki Shiraki
Publikováno v:
Pancreas. 50:744-750
Although neoadjuvant chemotherapy (NAC)-gemcitabine plus S-1 (GS) has been reported to have a survival benefit in patients with resectable pancreatic ductal adenocarcinoma (PDAC), optimal candidates for NAC-GS have not been clearly identified.A total
Publikováno v:
Psychosomatic Medicine. 83:795-804
OBJECTIVE The neurotrophic hypothesis of depression posits that stress and depression decrease neurotrophic factor expression in brain, whereas antidepressants and exercise can contribute to the blockade of stress effects and produce antidepressant e
Publikováno v:
Current Opinion in Endocrinology, Diabetes & Obesity. 28:318-324
Purpose of review The introduction of synthetic glucocorticoids 70 years ago made survival possible in classic 21-hydroxylase deficiency (21OHD). The currently used glucocorticoid therapy may lead to unphysiological dosing with negative consequencies
Publikováno v:
Journal of Trauma and Acute Care Surgery. 90:866-873
Background Traumatic brain injury is the leading cause of acquired neurologic disability in children. In our model of pediatric traumatic brain injury, controlled cortical impact (CCI) in rat pups, docosahexaenoic acid (DHA) improved lesion volume an
Publikováno v:
Annals of Medicine and Surgery. 61:188-197
Diabetes mellitus (DM) has been treated with herbs for centuries and many herbs reported to exert antidiabetic activity. Laurus nobilis is an aromatic herb belonging to the Lauraceae family, commonly known as bay. This study aimed to investigate the
Publikováno v:
Journal of Pediatric Hematology/Oncology. 43:186-192
Introduction To clarify mechanisms of ineffective erythropoiesis on iron metabolism, studies on erythroid factors that regulating hepcidin suppression have been carried out. The aim of the current study is to identify associations between erythropoie
Autor:
Hung-Pei Tsai, Yu-Hua Huang, Shu-Chuan Wu, Chia-Li Chung, Chee-Yin Chai, Rong-Dar Tzou, Aij-Lie Kwan, Tao-Chen Lee
Publikováno v:
International Journal of Surgery. 83:246-252
Background Hyperglycemia, a derangement after subarachnoid hemorrhage (SAH), is known to be associated with unfavorable outcomes. Whether the connection between hyperglycemia and poor prognosis results from severe neuronal apoptosis is unknown, and w
Publikováno v:
Hypertension
Maternal-fetal crosstalk has been implicated in long-term control of the health of offspring, including transgenerational hypertension. However, current knowledge is limited regarding maternal influences on the gut and its microbiome in blood pressur
Autor:
Mitchell J. Cohen, Jason M. Samuels, Kirk C. Hansen, Ernest E. Moore, Grant W. Hennig, Julia R. Coleman, Nicholas D Grubinger, Kalev Freeman
Publikováno v:
J Trauma Acute Care Surg
BACKGROUND: While tissue injury provokes fibrinolysis shutdown in trauma, the mechanism remains elusive. Cellular death causes release of structural proteins, including actin and myosin, which may interact with clot formation and structure. We hypoth