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Publikováno v:
Journal of Cardiovascular Pharmacology. 79:335-341
This study aimed to investigate the role of ginsenoside Rh1 in regulating the proliferation, apoptosis, and oxidative stress in oxidized low-density lipoprotein (ox-LDL)-treated human vascular endothelial cells (VECs) and the underlying mechanisms. V
Autor:
Shenghua Zhou, Yuting Cui, Hao Yin, Zhihan Tang, Yu Gui, Shi Tai, Darrell D. Belke, Binjie Yan, Xi-Long Zheng, Yanan Guo, Juan Peng
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 42:67-86
Objective: PCSK9 (proprotein convertase subtilisin/kexin type 9) plays a critical role in cholesterol metabolism via the PCSK9–LDLR (low-density lipoprotein receptor) axis in the liver; however, evidence indicates that PCSK9 directly contributes to
Publikováno v:
Journal of Cardiovascular Pharmacology. 78:809-818
There is evidence that the development of atherosclerosis (AS) involves the dysregulation of circular RNAs. This study aimed to investigate the role of circular ubiquitin-specific peptidase 9 X-linked (circUSP9X) in AS cell models. Human umbilical ve
Autor:
Jacquelyn J. Maher, Aras N. Mattis, Ke Liu, Tao Su, Caitlin Peaslee, Sneha Rao, Cristina Esteva-Font, Julie B. Sneddon, Antonio Munoz-Howell, Zhe Liu, Caroline C. Duwaerts, Marisa W. Medina
Publikováno v:
Hepatology (Baltimore, Md.), vol 74, iss 4
Hepatology
Hepatology
BACKGROUND AND AIMS: Induced pluripotent stem cells (iPSCs) provide an important tool for the generation of patient-derived cells, including hepatocyte-like cells, by developmental cues through an endoderm intermediate. However, most iPSC lines fail
Autor:
Ryan R. Gough, Melissa S. Holzapfel, Paul G. Thomes, Jacy L. Kubik, Carol A. Casey, Artem N. Pachikov, Amanda J. Macke, Armen Petrosyan, Mary E. Morris
Publikováno v:
Hepatology Communications, Vol 6, Iss 2, Pp 374-388 (2022)
Hepatology Communications
Hepatology Communications
Previous work from our laboratories has identified multiple defects in endocytosis, protein trafficking, and secretion, along with altered Golgi function after alcohol administration. Manifestation of alcohol‐associated liver disease (ALD) is assoc
Autor:
Shan Xia, Guijia Huang, Yin Zou, Zhengjun Qi, Zhi Huang, Bi Wang, Yu Huang, Yi Liu, Yingnan Yuan
Publikováno v:
Anti-Cancer Drugs. 33:e198-e206
Growing evidence has shown that aerobic glycolysis, as a hallmark of cancer cells, plays a crucial role in cervical cancer. The aim of the study is to uncover whether fructose-1,6-bisphosphatase 2 (FBP2) is involved in cervical cancer progression via
Autor:
Bruce A. Yankner, Liviu Aron, Christophe Legendre, Fabiola Terzi, Guillaume Canaud, Clément Hoguin, Pierre Isnard, Sato Magassa
Publikováno v:
J Am Soc Nephrol
Background Chronic kidney disease is associated with the loss of functional nephrons, leading to increased mechanical and metabolic stress in the remaining cells, particularly for cells constituting the filtration barrier, such as podocytes. The fail
Publikováno v:
Journal of Cardiovascular Pharmacology. 78:235-246
Long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) was reported to be related to atherosclerosis (AS) progression. However, the underlying mechanism of MALAT1 in AS remains unknown. Quantitative real-time polymerase c
Publikováno v:
Anti-Cancer Drugs
Activatable cell-penetrating peptide (ACPP) is a tumour-targeting cell-penetrating peptide. Here, we used ACPP to carry anti-p21Ras scFv for Ras-driven cancer therapy. The ACPP-p21Ras scFv fusion protein was prepared by a prokaryotic expression syste
Publikováno v:
Pancreas. 50:756-765
Objectives This study aimed to investigate the effect and mechanism of hypoxia on pancreatic cancer (PC) cell dedifferentiation and tumorigenic potential. Methods Inhibition of hypoxia-inducible factor 1α (HIF-1α) and overexpression of Notch1 in PC