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Autor:
Bruce A. Yankner, Liviu Aron, Christophe Legendre, Fabiola Terzi, Guillaume Canaud, Clément Hoguin, Pierre Isnard, Sato Magassa
Publikováno v:
J Am Soc Nephrol
Background Chronic kidney disease is associated with the loss of functional nephrons, leading to increased mechanical and metabolic stress in the remaining cells, particularly for cells constituting the filtration barrier, such as podocytes. The fail
Publikováno v:
Journal of Cardiovascular Pharmacology. 78:235-246
Long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) was reported to be related to atherosclerosis (AS) progression. However, the underlying mechanism of MALAT1 in AS remains unknown. Quantitative real-time polymerase c
Publikováno v:
Journal of Cardiovascular Pharmacology. 77:480-490
Atherosclerosis is a chronic lipid-induced inflammation of the vessel wall. Oxidized low-density lipoprotein was confirmed to drive the onset of atherogenesis. Zinc finger e-box-binding homeobox 1 antisense 1 (ZEB1-AS1) is a long noncoding RNA that i
Publikováno v:
Journal of Cardiovascular Pharmacology. 76:533-539
Myocardial ischemia is a common reason that causes human death globally. Long noncoding RNA taurine upregulated 1 (TUG1) serves as an oncogene in a variety of cancers. In this article, we aimed to investigate the role of TUG1 and its underlying signa
Publikováno v:
Shock. 52:249-256
Background Ischemic postconditioning (I/Post) is an endogenous protection mechanism that reduces injury induced by ischemia-reperfusion (I/R). It remains controversial whether I/Post protects against I/R injury to the aging heart. The long non-coding
Publikováno v:
Journal of the American Society of Nephrology. 29:1077-1079
Nonmicrobial inflammation contributes to CKD progression and fibrosis. Absent in melanoma 2 (AIM2) is an inflammasome-forming receptor for double-stranded DNA. AIM2 is expressed in the kidney and activated mainly by macrophages. We investigated the p
Autor:
Ken Arai
Publikováno v:
Stroke. 50
Advancing age is major risk factor for development of many central nervous system diseases including stroke. Three recent studies provide novel mechanisms for how aging causes brain dysfunction with implications for potential targets for stroke thera
Autor:
Fang Wu, Lu Yang, Shujun Zhang, Wanjiang Zhang, Wang Xinmin, Le Zhang, Yingzi Wang, Xiaofang Wang, Ling Han
Publikováno v:
Medicine
Background: Myeloid cell leukemia-1 (Mcl-1) plays an important role in the clearance of Mycobacterium tuberculosis (MTB) infection. It has the effect of anti-apoptosis, protecting macrophages that have engulfed pathogens and preventing pathogen clear
Autor:
Linden A. Green, Julie A. Mund, Michael P. Murphy, Victor Njoku, Matthias Clauss, Jamie Case, Mervin C. Yoder
Publikováno v:
Circulation Research. 118:1512-1524
Rationale: Transmembrane tumor necrosis factor-α (tmTNF-α) is the prime ligand for TNF receptor 2, which has been shown to mediate angiogenic and blood vessel repair activities in mice. We have previously reported that the angiogenic potential of h
Publikováno v:
Anti-Cancer Drugs
Para-toluenesulfonamide (PTS) has been implicated with anticancer effects against a variety of tumors. In the present study, we investigated the inhibitory effects of PTS on tongue squamous cell carcinoma (Tca-8113) and explored the lysosomal and mit