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Publikováno v:
Journal of Cardiovascular Pharmacology. 79:335-341
This study aimed to investigate the role of ginsenoside Rh1 in regulating the proliferation, apoptosis, and oxidative stress in oxidized low-density lipoprotein (ox-LDL)-treated human vascular endothelial cells (VECs) and the underlying mechanisms. V
Autor:
Jacquelyn J. Maher, Aras N. Mattis, Ke Liu, Tao Su, Caitlin Peaslee, Sneha Rao, Cristina Esteva-Font, Julie B. Sneddon, Antonio Munoz-Howell, Zhe Liu, Caroline C. Duwaerts, Marisa W. Medina
Publikováno v:
Hepatology (Baltimore, Md.), vol 74, iss 4
Hepatology
Hepatology
BACKGROUND AND AIMS: Induced pluripotent stem cells (iPSCs) provide an important tool for the generation of patient-derived cells, including hepatocyte-like cells, by developmental cues through an endoderm intermediate. However, most iPSC lines fail
Autor:
Shan Xia, Guijia Huang, Yin Zou, Zhengjun Qi, Zhi Huang, Bi Wang, Yu Huang, Yi Liu, Yingnan Yuan
Publikováno v:
Anti-Cancer Drugs. 33:e198-e206
Growing evidence has shown that aerobic glycolysis, as a hallmark of cancer cells, plays a crucial role in cervical cancer. The aim of the study is to uncover whether fructose-1,6-bisphosphatase 2 (FBP2) is involved in cervical cancer progression via
Autor:
Bruce A. Yankner, Liviu Aron, Christophe Legendre, Fabiola Terzi, Guillaume Canaud, Clément Hoguin, Pierre Isnard, Sato Magassa
Publikováno v:
J Am Soc Nephrol
Background Chronic kidney disease is associated with the loss of functional nephrons, leading to increased mechanical and metabolic stress in the remaining cells, particularly for cells constituting the filtration barrier, such as podocytes. The fail
Publikováno v:
Journal of Cardiovascular Pharmacology. 78:235-246
Long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) was reported to be related to atherosclerosis (AS) progression. However, the underlying mechanism of MALAT1 in AS remains unknown. Quantitative real-time polymerase c
Publikováno v:
Anti-Cancer Drugs
Activatable cell-penetrating peptide (ACPP) is a tumour-targeting cell-penetrating peptide. Here, we used ACPP to carry anti-p21Ras scFv for Ras-driven cancer therapy. The ACPP-p21Ras scFv fusion protein was prepared by a prokaryotic expression syste
Publikováno v:
Pancreas. 50:756-765
Objectives This study aimed to investigate the effect and mechanism of hypoxia on pancreatic cancer (PC) cell dedifferentiation and tumorigenic potential. Methods Inhibition of hypoxia-inducible factor 1α (HIF-1α) and overexpression of Notch1 in PC
Publikováno v:
Journal of Cardiovascular Pharmacology. 77:480-490
Atherosclerosis is a chronic lipid-induced inflammation of the vessel wall. Oxidized low-density lipoprotein was confirmed to drive the onset of atherogenesis. Zinc finger e-box-binding homeobox 1 antisense 1 (ZEB1-AS1) is a long noncoding RNA that i
Publikováno v:
J Am Soc Nephrol
In the past few decades, sphingolipids and sphingolipid metabolites have gained attention because of their essential role in the pathogenesis and progression of kidney diseases. Studies in models of experimental and clinical nephropathies have descri
Publikováno v:
Journal of Cardiovascular Pharmacology. 76:533-539
Myocardial ischemia is a common reason that causes human death globally. Long noncoding RNA taurine upregulated 1 (TUG1) serves as an oncogene in a variety of cancers. In this article, we aimed to investigate the role of TUG1 and its underlying signa