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Autor:
Zhang Zhi, Gaofeng Wu, Zhuoqun Fang, Li Yao, Juntao Han, Xuekang Yang, Xudong Deng, Dongliang Zhang
Publikováno v:
Shock. 54:819-827
Na/H exchanger 1 (NHE1) is a ubiquitously expressed protein on mammalian plasma membranes and involved in cell apoptosis and tissue injury. Our previous study found that NHE1 inhibition prevents burn-induced acute lung injury (ALI). However, the pote
Publikováno v:
Journal of Cardiovascular Pharmacology. 74:53-61
Aim Vascular endothelial cell dysfunction plays a crucial role in the initiation and development of atherosclerosis. Physcion 8-O-β-glucopyranoside (PG), an anthraquinone extracted from Polygonum cuspidatum, has a number of pharmacological functions
Autor:
Qing Jing, Yong-wen Qin, Xiao-Xu Qiu, Qian‐Qian Jia, Chen Wang, Yong-Qin Li, Huang-Tian Yang, Yang Liu, He Liang, Xianxian Zhao, Zhang Yifan, Shuang Huang, Ya-Na Guan
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Cardiomyocytes differentiated from human pluripotent stem cells can serve as an unexhausted source for a cellular cardiac disease model. Although small molecule–mediated cardiomyocyte differentiation methods have been established, the di
Autor:
Jin Yao, Qin Jiang, Yu-Jie Li, Jing-Yu Liu, Zhi-Fu Tao, Qi Chen, Xiao-Qun Wang, Biao Yan, Yu-Chen Song, Xiu-Miao Li
Publikováno v:
Circulation Research. 116:1143-1156
Rationale: Pathological angiogenesis is a critical component of diseases, such as ocular disorders, cancers, and atherosclerosis. It is usually caused by the abnormal activity of biological processes, such as cell proliferation, cell motility, immune
Autor:
Arianna Cattelan, Theresa Schmitz, Sarah Vosen, Bernardo S. Franklin, Bernd K. Fleischmann, Xiaoyan Yang, Nikos Werner, Daniela Wenzel, Felix Jansen, Sebastian Proebsting, Marion Hoelscher, Georg Nickenig
Publikováno v:
Circulation. 128:2026-2038
Background— Repair of the endothelium after vascular injury is crucial for preserving endothelial integrity and preventing the development of vascular disease. The underlying mechanisms of endothelial cell repair are largely unknown. We sought to i
Autor:
Camille Ettelaie, Mary E. W. Collier
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 30:1810-1817
Objective— Increased levels of circulating tissue factor (TF) in the form of microparticles increase the risk of thrombosis. However, any direct influence of microparticle-associated TF on vascular endothelial cell proliferation is not known. In th
Publikováno v:
ASAIO Journal. 56:468-474
There is increasing evidence suggesting that oxidative modification of low-density lipoprotein (ox-LDL) in the vessel wall plays a crucial role in the initiation and progression of atherogenesis. The purpose of this study is to substantiate our hypot
Autor:
Gang Wang, Yanhua Hu, Justin C. Mason, Gillian W. Cockerill, Qingzhong Xiao, Qingbo Xu, Elena deFalco, Anna Elena Pepe, Zhongyi Zhang, Andriana Margariti, Ouassila Habi, Lingfang Zeng, Anna Zampetaki, Hongling Li
Publikováno v:
Circulation. 121:132-142
Background— Histone deacetylase 3 (HDAC3) is known to play a crucial role in the differentiation of endothelial progenitors. The role of HDAC3 in mature endothelial cells, however, is not well understood. Here, we investigated the function of HDAC3
Autor:
Qian Zhou, Christoph Zoeller, W. Cam Patterson, Jennifer Heinke, Kim Miriam Baar, Martin Moser, Leonie Wehofsits, Hellmut G. Augustin, Thomas Helbing, Anna M. Laib, Christoph Bode
Publikováno v:
Circulation Research. 103:804-812
Bone morphogenetic proteins (BMPs) are involved in embryonic and adult blood vessel formation in health and disease. BMPER (BMP endothelial cell precursor–derived regulator) is a differentially expressed protein in embryonic endothelial precursor c
Autor:
Kenneth Walsh, Jeong-Sun Seo, Young Bae Park, Byung Hee Oh, Kyung Woo Park, Seock Won Youn, Hae Young Lee, Joo Yun Won, Hyun Jung You, Hyun Jai Cho, Hyo-Soo Kim, Woong-Yang Park
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 28:302-308
Background— The forkhead factor, FOXO3a, is known to induce apoptosis in endothelial cells (ECs). However, its effects on extracellular matrices (ECM), which are important in EC survival, remained unknown. Here, we evaluated the role of FOXO3a on E