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Autor:
Shan Xia, Guijia Huang, Yin Zou, Zhengjun Qi, Zhi Huang, Bi Wang, Yu Huang, Yi Liu, Yingnan Yuan
Publikováno v:
Anti-Cancer Drugs. 33:e198-e206
Growing evidence has shown that aerobic glycolysis, as a hallmark of cancer cells, plays a crucial role in cervical cancer. The aim of the study is to uncover whether fructose-1,6-bisphosphatase 2 (FBP2) is involved in cervical cancer progression via
Publikováno v:
Journal of Cardiovascular Pharmacology. 77:480-490
Atherosclerosis is a chronic lipid-induced inflammation of the vessel wall. Oxidized low-density lipoprotein was confirmed to drive the onset of atherogenesis. Zinc finger e-box-binding homeobox 1 antisense 1 (ZEB1-AS1) is a long noncoding RNA that i
Publikováno v:
Anti-Cancer Drugs. 30:128-137
Physalin B (PB) is one of the major constituents of Physalis alkekengi var. franchetii, a well-known Chinese traditional herb. In this study, we demonstrated for the first time that PB exhibits significant antiproliferative and apoptotic activity in
Publikováno v:
Journal of Cardiovascular Pharmacology. 71:293-302
Purpose The aim of this study is to investigate the potential roles of Rutaecarpine (Rut) in hypoxia-induced human pulmonary artery smooth muscle cells (HPASMCs) model. Methods HPASMCs were cultured with or without hypoxia followed by Rut administrat
Publikováno v:
Journal of Craniofacial Surgery. 28:1481-1485
Craniosynostosis is a complex disease condition, which involves premature fusion of cranial vault sutures and lacks desirable treatment. Previous studies have demonstrated decreased proliferation rate of osteoblasts and downregulated expression of gl
Publikováno v:
Neuroreport
There are several forms of brain-derived neurotrophic factor (BDNF), the precursor of BDNF, mature BDNF, and BDNF propeptide. They exert different effects through different transmembrane receptor signaling systems. Precursor of BDNF is enzymatically
Publikováno v:
Spine. 42:E757-E766
STUDY DESIGN Experimental in vivo and in vitro study of intervertebral disc (IVD) degeneration and the mechanism exploration. OBJECTIVE This report aims to verify the expression of Sirt1 in IVD degeneration of different grades and explore its potenti
Autor:
Qing Jing, Yong-wen Qin, Xiao-Xu Qiu, Qian‐Qian Jia, Chen Wang, Yong-Qin Li, Huang-Tian Yang, Yang Liu, He Liang, Xianxian Zhao, Zhang Yifan, Shuang Huang, Ya-Na Guan
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Cardiomyocytes differentiated from human pluripotent stem cells can serve as an unexhausted source for a cellular cardiac disease model. Although small molecule–mediated cardiomyocyte differentiation methods have been established, the di
Autor:
Jin Yao, Qin Jiang, Yu-Jie Li, Jing-Yu Liu, Zhi-Fu Tao, Qi Chen, Xiao-Qun Wang, Biao Yan, Yu-Chen Song, Xiu-Miao Li
Publikováno v:
Circulation Research. 116:1143-1156
Rationale: Pathological angiogenesis is a critical component of diseases, such as ocular disorders, cancers, and atherosclerosis. It is usually caused by the abnormal activity of biological processes, such as cell proliferation, cell motility, immune
Publikováno v:
Anti-Cancer Drugs. 25:998-1006
Lung cancer remains the most common cause of cancer-related death worldwide. This malignancy is a complex disease, and it is important to identify potential biological targets, the blockade of which would affect multiple downstream signaling cascades