Zobrazeno 1 - 10
of 39
pro vyhledávání: ''
Publikováno v:
NeuroReport. 27:730-736
Parkinson's disease (PD) can be ascribed to the progressive and selective loss of dopaminergic neurons in the substantia nigra pars compacta, and thus molecules with neuroprotective ability may have therapeutic value against PD. In the current study,
Autor:
Bei-Xin Yu, Xiao-Yi Mai, Xiaofei Lv, Jie Liu, Jie-Sheng Qian, Fei-Ran Zhang, Ying-ying Liu, Jing-Song Ou, De-Yi Zeng, Qian-Qian Wu, Si-Jia Liang, Jin-Yan Shang, Jia-Guo Zhou, Jia-Ni Yuan, Ping Zhou
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 36:618-628
Objective— To determine the role of orai1 store–operated Ca 2+ entry in foam cell formation and atherogenesis. Approach and Results— Acute administration of oxidized low-density lipoprotein (oxLDL) activates an orai1-dependent Ca 2+ entry in ma
Autor:
Jianhua Zhang, Fei Yu, Hai-Qing Gao, Qian Cai, Baoying Li, Wen-bin Yin, Jun-fu Wang, Zhen Zhang, Rui-Hai Zhou, Xiao-li Li, Mei Cheng
Publikováno v:
Journal of Cardiovascular Pharmacology. 65:13-21
Elevated level of glycated low-density lipoproteins (glyLDL) is believed to contribute to endothelial dysfunction, which is involved in the pathogenesis and acceleration of diabetic vascular diseases. Grape seed procyanidin B2 (GSPB2) has been report
Autor:
Brian O'Rourke, Anders O. Garlid, Alice S Ho, Agnieszka Sidor, D. Brian Foster, Keith D. Garlid, Jasma Rucker, Ling Chen
Publikováno v:
Circulation Research. 111:446-454
Rationale: Activation of the mitochondrial ATP-sensitive potassium channel (mitoK ATP ) has been implicated in the mechanism of cardiac ischemic preconditioning, yet its molecular composition is unknown. Objective: To use an unbiased proteomic analys
Autor:
Anita Aperia
Publikováno v:
Journal of the American Society of Nephrology. 23:1283-1290
The ability of cells to maintain sharp ion gradients across their membranes is the foundation for the molecular transport and electrical excitability. Across animal species and cell types, Na(+),K(+)-adenosine triphosphatase (ATPase) is arguably the
Autor:
Ulrich Beuers, Sandra J. van Vliet, Douglas M. Jefferson, Simon Hohenester, Ronald P.J. Oude Elferink, Coen C. Paulusma, Lucas Maillette de Buy Wenniger
Publikováno v:
Hepatology, 55(1), 173-183. John Wiley and Sons Ltd
Hepatology (Baltimore, Md.), 55(1), 173-183. John Wiley and Sons Ltd
Hohenester, S, Wenniger, L M D, Paulusma, C C, van Vliet, S J, Jefferson, D M, Elferink, R P O & Beuers, U 2012, ' A biliary HCO3-umbrella constitutes a protective mechanism against bile acid-induced injury in human cholangiocytes ', Hepatology, vol. 55, no. 1, pp. 173-183 . https://doi.org/10.1002/hep.24691
Hepatology (Baltimore, Md.), 55(1), 173-183. John Wiley and Sons Ltd
Hohenester, S, Wenniger, L M D, Paulusma, C C, van Vliet, S J, Jefferson, D M, Elferink, R P O & Beuers, U 2012, ' A biliary HCO3-umbrella constitutes a protective mechanism against bile acid-induced injury in human cholangiocytes ', Hepatology, vol. 55, no. 1, pp. 173-183 . https://doi.org/10.1002/hep.24691
Human cholangiocytes are continuously exposed to millimolar levels of hydrophobic bile salt monomers. We recently hypothesized that an apical biliary HCO?3- umbrella might prevent the protonation of biliary glycine-conjugated bile salts and uncontrol
Autor:
Camille Ettelaie, Mary E. W. Collier
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 30:1810-1817
Objective— Increased levels of circulating tissue factor (TF) in the form of microparticles increase the risk of thrombosis. However, any direct influence of microparticle-associated TF on vascular endothelial cell proliferation is not known. In th
Autor:
Yun Mi Kim, Jong Chul Won, Min-Seon Kim, Ki-Up Lee, Jin Han, Tae-Sik Park, Jang H. Youn, Jung Ran Kim, Inkyu Lee, Cheol Soo Choi, Eun Hee Koh, Woo Je Lee, Byeong Hwan Jeon, Joong-Yeol Park, Somi Seol
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 30:290-297
Objective— Fatty acids increase reactive oxygen species generation and cell apoptosis in endothelial cells. The peroxisome proliferator-activated receptor-γ coactivator 1-α (PGC-1α) is a transcriptional coactivator that increases mitochondrial b
Autor:
Gang Wang, Yanhua Hu, Justin C. Mason, Gillian W. Cockerill, Qingzhong Xiao, Qingbo Xu, Elena deFalco, Anna Elena Pepe, Zhongyi Zhang, Andriana Margariti, Ouassila Habi, Lingfang Zeng, Anna Zampetaki, Hongling Li
Publikováno v:
Circulation. 121:132-142
Background— Histone deacetylase 3 (HDAC3) is known to play a crucial role in the differentiation of endothelial progenitors. The role of HDAC3 in mature endothelial cells, however, is not well understood. Here, we investigated the function of HDAC3
Autor:
Sanson, Marie, Augé, Nathalie, Vindis, Cécile, Muller, Carole, Bando, Yoshio, Thiers, Jean-Claude, Marachet, Marie-Agnè, s, Žarković, Kamelija, Sawa, Yoshiki, Salvayre, Robert, Nè, gre-Salvayre, Anne
Publikováno v:
Circulation Research
Circulation Research, 2009, 104 (3), pp.328-36. ⟨10.1161/CIRCRESAHA.108.183749⟩
Circulation Research, American Heart Association, 2009, 104 (3), pp.328-36. ⟨10.1161/CIRCRESAHA.108.183749⟩
Circulation Research, 2009, 104 (3), pp.328-36. ⟨10.1161/CIRCRESAHA.108.183749⟩
Circulation Research, American Heart Association, 2009, 104 (3), pp.328-36. ⟨10.1161/CIRCRESAHA.108.183749⟩
Oxidized low-density lipoproteins (oxLDLs) trigger various biological responses potentially involved in atherogenesis. Disturbing endoplasmic reticulum (ER) function results in ER stress and unfolded protein response, which tends to restore ER homeos